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• W1680442092 endingPage "2633" @default.
• W1680442092 startingPage "2620" @default.
• W1680442092 abstract "Abstract With the use of single-cell digital imaging of the fluorescent Ca2+ indicator dye fura-2 we investigated Ca2+ signaling in human T lymphocytes and NK cells during activation by a variety of stimuli. A low percentage of resting T cells or T cell blasts displayed oscillations in cytosolic Ca2+ when stimulated with the mitogenic lectin PHA or by the addition of OKT3 mAb followed by a secondary cross-linking antibody. Lymphokine-activated T killer cells were more responsive than resting cells. A comparison of PHA, cross-linked anti-CD3, and a heteroconjugate mAb showed that at least 20% of the cells from these T cell preparations oscillated. Addition of PHA or cross-linked anti-CD16 caused NK cells to oscillate. In contrast, thapsigargin, a microsomal ATPase blocker, resulted in a relatively uniform, slowly rising and sustained Ca2+ response in all cell types studied. The maintenance of both thapsigargin- and receptor-induced responses required Ca2+ influx driven by a negative membrane potential. Because Ca2+ oscillations occurred in response to stimuli which mimic the normal activation of lymphocytes, and inasmuch as the percentage of oscillating cells increases with state of activation, these oscillations may play an important role in mitogenic activation." @default.
• W1680442092 created "2016-06-24" @default.
• W1680442092 creator A5003506967 @default.
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• W1680442092 date "1993-04-01" @default.
• W1680442092 modified "2023-10-16" @default.
• W1680442092 title "Calcium oscillations in human T and natural killer cells depend upon membrane potential and calcium influx." @default.
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• W1680442092 doi "https://doi.org/10.4049/jimmunol.150.7.2620" @default.
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