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- W168047647 abstract "Objective To explore the prognostic factors of primary nodal diffuse large B-cell lymphomas(N-DLBCL). Methods According to the 2001 WHO classification of tumors of hematopoietic and lymphoid tissue, 51 cases of primary N-DLBCL were collected for clinical data analysis and immunohistochemical assay. Antibodies used for study were anti-CD20,CD79α,CD45RO,CD3,Bcl-2,Ki-67,CD30,CD15,κ,λ,Cyclin D1,TdT,GFAP,CK,MPO. The survival data was analyzed. Results Of the 51 cases of N-DLBCLs, 40 were reclassified as centroblastic, 3 B-immunoblastic, 1 T-cell/histiocytes rich, 2 B-cell anaplastic large cell, 1 plasmablastic, and 4 unclassified. Expression of Bcl-2 oncoprotein was observed in 24 cases (47.1%). The median Ki-67 index was 50.0% and the index more than 40% was found in 35 cases (68.6%). Survival analysis of 35 cases had follow up data showed that the 2 year and 5-year overall survival (OS) rates were 48.54% and 35.30%, respectively. The 5- year OS rates patients with International Prognosis Index(IPI)≥3 was lower than that with IPI3 (P0.01). The 5-year OS rates for patients with B symptoms was lower than that without B symptoms (P0.05). The 5-year OS rates for patients with Ki-67 index more than 40% was lower than that with less than 40% (P0.05). The expression of Bcl-2 oncoprotein was irrelative to prognosis(P0.05). Conclusion IPI, B symptoms and Ki-67 index are the prognostic factors for patients with N-DLBCL." @default.
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- W168047647 date "2005-04-01" @default.
- W168047647 modified "2023-09-22" @default.
- W168047647 title "[Prognostic analysis of 51 cases of primary nodal diffuse large B-cell lymphomas]." @default.
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