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- W1680571683 abstract "Fitness landscapes are a classical concept for thinking about the relationship between genotype and fitness. However, because the space of genotypes is typically high‐dimensional, the structure of fitness landscapes can be difficult to understand and the heuristic approach of thinking about fitness landscapes as low‐dimensional, continuous surfaces may be misleading. Here, I present a rigorous method for creating low‐dimensional representations of fitness landscapes. The basic idea is to plot the genotypes in a manner that reflects the ease or difficulty of evolving from one genotype to another. Such a layout can be constructed using the eigenvectors of the transition matrix describing the evolution of a population on the fitness landscape when mutation is weak. In addition, the eigendecomposition of this transition matrix provides a new, high‐level view of evolution on a fitness landscape. I demonstrate these techniques by visualizing the fitness landscape for selection for the amino acid serine and by visualizing a neutral network derived from the RNA secondary structure genotype–phenotype map." @default.
- W1680571683 created "2016-06-24" @default.
- W1680571683 creator A5001650268 @default.
- W1680571683 date "2011-03-01" @default.
- W1680571683 modified "2023-09-25" @default.
- W1680571683 title "VISUALIZING FITNESS LANDSCAPES" @default.
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- W1680571683 doi "https://doi.org/10.1111/j.1558-5646.2011.01236.x" @default.
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