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• W1680693957 endingPage "5066" @default.
• W1680693957 startingPage "5057" @default.
• W1680693957 abstract "The CD21/35 proteins are complement receptors implicated in controlling and interpreting activation states of the innate and acquired immune responses. One defect of CD21/35(-/-) animals is depressed production of Ag-specific IgG3 which we show is evident in vivo but not in vitro. Gene expression profiles obtained from naive wild-type and CD21/35(-/-) splenocytes demonstrated enhanced expression of inflammatory mediators from CD11b(+) splenocytes in the CD21/35(-/-) animals. Splenocyte populations between wild-type and CD21/35(-/-) mice were similar except for a moderate increase in GR1(low)CD31(+) immature myeloid cells. Furthermore, depletion of neutrophils and other GR1-expressing cells alleviates elevated inflammatory gene expression in the CD21/35(-/-) spleen. Complement activation also plays a key role in the differential gene expression observed in the CD21/35-deficient mouse as depletion of C3 or inhibition of C3a receptor signaling within the animal returned inflammatory gene expression within the spleen to wild-type levels. Finally, C3 depletion before immunization allowed for the enhanced production of Ag-specific IgG3 production in the CD21/35(-/-) mouse compared with mock-depleted animals. These data suggest that the overall environment of the CD21/35(-/-) spleen is quite different from that of the wild-type animal perhaps due to altered complement convertase activity. This difference may be responsible for a number of the phenotypes ascribed to the deficiency of CD21/35 proteins on B cells and follicular dendritic cells." @default.
• W1680693957 created "2016-06-24" @default.
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• W1680693957 date "2008-04-01" @default.
• W1680693957 modified "2023-09-23" @default.
• W1680693957 title "Complement Receptors 1 and 2 Influence the Immune Environment in a B Cell Receptor-Independent Manner" @default.
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• W1680693957 doi "https://doi.org/10.4049/jimmunol.180.7.5057" @default.
• W1680693957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18354231" @default.
• W1680693957 hasPublicationYear "2008" @default.
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