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- W168075265 abstract "Evidence has been reported which suggests that fluid can be absorbed from the lungs of awake and anesthetized sheep. In this study, the authors investigated the movement of water and solutes between the airspaces and vasculature of isolated, fluid-filled rat lungs. A 1.0g/dl albumin, buffered Ringer's lactate solution containing the protein label, T-1824, was instilled into the airways and the lungs were perfused with the same solution. In addition, /sup 125/I-albumin, /sup 22/Na/sup +/ and /sup 3/H-mannitol were placed in the airway solution. Samples were obtained of the perfusate at intervals throughout the experiment and fluid remaining in the airspaces was pumped into serial sample tubes at the end of 1 or 2 hours. T-1824 concentrations increased by 6.6 +/- 0.4% (S.E., n=5) at 1 hr and 12.9 +/- 0.1% at 2 hr, indicating a corresponding absorption of protein-poor fluid from the alveoli. By 2 hr, perfusate T-1824 had fallen by 4.4 +/- .1%, indicating that a fraction of the fluid leaving the airspaces had reached the perfusate. Addition of 5 x 10/sup -5/ M terbutaline increased T-1824 concentrations by 11.4 +/- 1.4% at 1 hr, but at 2 hr., concentrations were much more variable, and an increase in themore » movement of /sup 3/H-mannitol suggested alveolar-capillary injury. 5 x 10/sup -4/M ouabain reduced the rate of both blood flow and fluid absorption. The data are consistent with active Na/sup +/ and fluid transport in the isolated lung. Although terbutaline may accelerate this process, it appears to damage the epithelial barrier by 2 hrs.« less" @default.
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- W168075265 date "1986-03-05" @default.
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- W168075265 title "Transport of fluid from airspaces to the vasculature of rat lungs" @default.
- W168075265 hasPublicationYear "1986" @default.
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