FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1680771593> ?p ?o ?g. }

• W1680771593 endingPage "4121" @default.
• W1680771593 startingPage "4112" @default.
• W1680771593 abstract "The reinforcing properties of cocaine can readily become associated with salient environmental stimuli that acquire secondary reinforcing properties. This form of classical conditioning is of considerable clinical relevance as intense craving can be evoked by the presentation of stimuli previously associated with the effects of cocaine. To understand better the neurobiology of cocaine-induced environment-specific conditioning, Fos expression was examined in the forebrain of rats exposed to an environment in which they had previously received cocaine. These results were compared to those observed following an acute injection of cocaine. Consistent with its stimulant actions, cocaine produced an increase in locomotion that was accompanied by an increase in Fos expression within specific limbic regions (cingulate cortex, claustrum, piriform cortex, lateral septal nucleus, paraventricular nucleus of the thalamus, lateral habenula, and amygdala) as well as the basal ganglia (dorsomedial striatum and nucleus accumbens). Exposure of rats to the cocaine-paired environment also produced an increase in locomotion, as compared to various control groups. In addition to this behavioral effect, conditioned subjects exhibited a significant increase in Fos expression within the cingulate cortex, claustrum, lateral septal nucleus, paraventricular nucleus of the thalamus, lateral habenula, and the amygdala, suggesting increased neuronal activity within these regions. In contrast to the dramatic effects observed within these structures, no conditional activation was observed within the piriform cortex, nucleus accumbens, or dorsal striatum, suggesting that these brain areas are not involved in the conditioned response. The present findings indicate that specific limbic regions exhibit increased neuronal activation during the presentation of cocaine-paired cues and may be involved in the formation of associations between cocaine's stimulant actions and the environment in which the drug administration occurred. Although the nucleus accumbens is necessary for the reinforcing and locomotor effects of cocaine, it does not exhibit a conditional Fos response, suggesting that different neural circuits are involved in the unconditioned and conditioned effects of cocaine." @default.
• W1680771593 created "2016-06-24" @default.
• W1680771593 creator A5034663097 @default.
• W1680771593 creator A5050966856 @default.
• W1680771593 creator A5073597315 @default.
• W1680771593 date "1992-10-01" @default.
• W1680771593 modified "2023-10-14" @default.
• W1680771593 title "Evidence for conditional neuronal activation following exposure to a cocaine-paired environment: role of forebrain limbic structures" @default.
• W1680771593 cites W1005072826 @default.
• W1680771593 cites W1446369482 @default.
• W1680771593 cites W1958695407 @default.
• W1680771593 cites W1964909230 @default.
• W1680771593 cites W1970238016 @default.
• W1680771593 cites W1971959365 @default.
• W1680771593 cites W1975146102 @default.
• W1680771593 cites W1978232917 @default.
• W1680771593 cites W1979339798 @default.
• W1680771593 cites W1980021607 @default.
• W1680771593 cites W1982292219 @default.
• W1680771593 cites W1982956447 @default.
• W1680771593 cites W1997373688 @default.
• W1680771593 cites W2001026574 @default.
• W1680771593 cites W2005657014 @default.
• W1680771593 cites W2005997674 @default.
• W1680771593 cites W2010569958 @default.
• W1680771593 cites W2015825603 @default.
• W1680771593 cites W2022395708 @default.
• W1680771593 cites W2026879846 @default.
• W1680771593 cites W2026887008 @default.
• W1680771593 cites W2028318252 @default.
• W1680771593 cites W2028416978 @default.
• W1680771593 cites W2033123455 @default.
• W1680771593 cites W2034744060 @default.
• W1680771593 cites W2035235513 @default.
• W1680771593 cites W2041637758 @default.
• W1680771593 cites W2045105543 @default.
• W1680771593 cites W2048195698 @default.
• W1680771593 cites W2051077097 @default.
• W1680771593 cites W2056965968 @default.
• W1680771593 cites W2058601367 @default.
• W1680771593 cites W2061418383 @default.
• W1680771593 cites W2062610641 @default.
• W1680771593 cites W2062911438 @default.
• W1680771593 cites W2063690168 @default.
• W1680771593 cites W2063841737 @default.
• W1680771593 cites W2069234276 @default.
• W1680771593 cites W2072305667 @default.
• W1680771593 cites W2075873783 @default.
• W1680771593 cites W2077803796 @default.
• W1680771593 cites W2080125844 @default.
• W1680771593 cites W2085582971 @default.
• W1680771593 cites W2089123987 @default.
• W1680771593 cites W2091059276 @default.
• W1680771593 cites W2091447846 @default.
• W1680771593 cites W2095217951 @default.
• W1680771593 cites W2118594719 @default.
• W1680771593 cites W2120125170 @default.
• W1680771593 cites W2142461382 @default.
• W1680771593 cites W2146835230 @default.
• W1680771593 cites W2153273004 @default.
• W1680771593 cites W2165398609 @default.
• W1680771593 cites W2210330010 @default.
• W1680771593 cites W2338384183 @default.
• W1680771593 cites W2442444099 @default.
• W1680771593 cites W793331764 @default.
• W1680771593 cites W971185581 @default.
• W1680771593 cites W103183767 @default.
• W1680771593 cites W1969793357 @default.
• W1680771593 doi "https://doi.org/10.1523/jneurosci.12-10-04112.1992" @default.
• W1680771593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6575978" @default.
• W1680771593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1403102" @default.
• W1680771593 hasPublicationYear "1992" @default.
• W1680771593 type Work @default.
• W1680771593 sameAs 1680771593 @default.
• W1680771593 citedByCount "278" @default.
• W1680771593 countsByYear W16807715932012 @default.
• W1680771593 countsByYear W16807715932013 @default.
• W1680771593 countsByYear W16807715932014 @default.
• W1680771593 countsByYear W16807715932015 @default.
• W1680771593 countsByYear W16807715932016 @default.
• W1680771593 countsByYear W16807715932017 @default.
• W1680771593 countsByYear W16807715932018 @default.
• W1680771593 countsByYear W16807715932019 @default.
• W1680771593 countsByYear W16807715932020 @default.
• W1680771593 countsByYear W16807715932021 @default.
• W1680771593 countsByYear W16807715932022 @default.
• W1680771593 countsByYear W16807715932023 @default.
• W1680771593 crossrefType "journal-article" @default.
• W1680771593 hasAuthorship W1680771593A5034663097 @default.
• W1680771593 hasAuthorship W1680771593A5050966856 @default.
• W1680771593 hasAuthorship W1680771593A5073597315 @default.
• W1680771593 hasBestOaLocation W16807715931 @default.
• W1680771593 hasConcept C15744967 @default.
• W1680771593 hasConcept C169760540 @default.
• W1680771593 hasConcept C2776287375 @default.
• W1680771593 hasConcept C2776552330 @default.
• W1680771593 hasConcept C2778187257 @default.
• W1680771593 hasConcept C2779144063 @default.

• next