Matches in SemOpenAlex for { <https://semopenalex.org/work/W168094672> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W168094672 endingPage "133.48" @default.
- W168094672 startingPage "133.48" @default.
- W168094672 abstract "Abstract Astrocytes are ideally positioned to detect and respond to invading pathogens of the CNS and previous studies have demonstrated the ability of these cells to produce key inflammatory mediators following exposure to members of the Mononegavirales order of viruses that are the causative agents of lethal human CNS diseases including rabies. However, the mechanisms by which resident cells of the CNS perceive such viral challenges have not been defined. Recently, several cytosolic DExD/H box RNA helicases have been described that can bind early viral replicative intermediates leading to the realization that retinoic acid-inducible gene I (RIG-I)-like helicases, such as RIG-I, function as intracellular receptors for RNA viruses. In the present study, we demonstrate that cultured primary human astrocytes constitutively express RIG-I receptor protein. Interestingly, such expression is rapidly elevated following exposure to vesicular stomatitis virus (VSV), a neurotropic rhabdovirus that closely resembles rabies virus. Evidence for the functional nature of RIG-I expression in human glial cells comes from the observation that this molecule associates with its downstream effector molecule, interferon promoter stimulator-1 (IPS-1), following VSV infection as assessed by co-immunoprecipitation techniques. Furthermore, we have confirmed that this molecule functions as an intracellular pattern recognition receptor in astrocytes by demonstrating that a putative ligand for RIG-I can elicit inflammatory cytokine production by this cell type. These findings raise the exciting possibility that RIG-I plays an important role in the detection of viral CNS pathogens and the initiation of protective immune responses or, alternatively, the progression of damaging inflammation within the brain." @default.
- W168094672 created "2016-06-24" @default.
- W168094672 creator A5009428973 @default.
- W168094672 creator A5034508784 @default.
- W168094672 creator A5085975858 @default.
- W168094672 creator A5014094266 @default.
- W168094672 date "2009-04-01" @default.
- W168094672 modified "2023-09-27" @default.
- W168094672 title "Primary human astrocytes functionally express RIG-I, a member of the retinoic acid-inducible gene-I family of viral pattern recognition receptors (133.48)" @default.
- W168094672 doi "https://doi.org/10.4049/jimmunol.182.supp.133.48" @default.
- W168094672 hasPublicationYear "2009" @default.
- W168094672 type Work @default.
- W168094672 sameAs 168094672 @default.
- W168094672 citedByCount "0" @default.
- W168094672 crossrefType "journal-article" @default.
- W168094672 hasAuthorship W168094672A5009428973 @default.
- W168094672 hasAuthorship W168094672A5014094266 @default.
- W168094672 hasAuthorship W168094672A5034508784 @default.
- W168094672 hasAuthorship W168094672A5085975858 @default.
- W168094672 hasConcept C104317684 @default.
- W168094672 hasConcept C134474686 @default.
- W168094672 hasConcept C136449434 @default.
- W168094672 hasConcept C159047783 @default.
- W168094672 hasConcept C166703698 @default.
- W168094672 hasConcept C170493617 @default.
- W168094672 hasConcept C2522874641 @default.
- W168094672 hasConcept C2776178377 @default.
- W168094672 hasConcept C2776954689 @default.
- W168094672 hasConcept C2779057330 @default.
- W168094672 hasConcept C2780355102 @default.
- W168094672 hasConcept C2780727368 @default.
- W168094672 hasConcept C2780813555 @default.
- W168094672 hasConcept C54355233 @default.
- W168094672 hasConcept C67705224 @default.
- W168094672 hasConcept C86803240 @default.
- W168094672 hasConcept C95444343 @default.
- W168094672 hasConceptScore W168094672C104317684 @default.
- W168094672 hasConceptScore W168094672C134474686 @default.
- W168094672 hasConceptScore W168094672C136449434 @default.
- W168094672 hasConceptScore W168094672C159047783 @default.
- W168094672 hasConceptScore W168094672C166703698 @default.
- W168094672 hasConceptScore W168094672C170493617 @default.
- W168094672 hasConceptScore W168094672C2522874641 @default.
- W168094672 hasConceptScore W168094672C2776178377 @default.
- W168094672 hasConceptScore W168094672C2776954689 @default.
- W168094672 hasConceptScore W168094672C2779057330 @default.
- W168094672 hasConceptScore W168094672C2780355102 @default.
- W168094672 hasConceptScore W168094672C2780727368 @default.
- W168094672 hasConceptScore W168094672C2780813555 @default.
- W168094672 hasConceptScore W168094672C54355233 @default.
- W168094672 hasConceptScore W168094672C67705224 @default.
- W168094672 hasConceptScore W168094672C86803240 @default.
- W168094672 hasConceptScore W168094672C95444343 @default.
- W168094672 hasIssue "1_Supplement" @default.
- W168094672 hasLocation W1680946721 @default.
- W168094672 hasOpenAccess W168094672 @default.
- W168094672 hasPrimaryLocation W1680946721 @default.
- W168094672 hasRelatedWork W1645018133 @default.
- W168094672 hasRelatedWork W2006660108 @default.
- W168094672 hasRelatedWork W2026005982 @default.
- W168094672 hasRelatedWork W2046150260 @default.
- W168094672 hasRelatedWork W2050378052 @default.
- W168094672 hasRelatedWork W2072431682 @default.
- W168094672 hasRelatedWork W2136046700 @default.
- W168094672 hasRelatedWork W2136978151 @default.
- W168094672 hasRelatedWork W2312143864 @default.
- W168094672 hasRelatedWork W4313382732 @default.
- W168094672 hasVolume "182" @default.
- W168094672 isParatext "false" @default.
- W168094672 isRetracted "false" @default.
- W168094672 magId "168094672" @default.
- W168094672 workType "article" @default.