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• W168114416 abstract "In this chapter we describe the emerging framework for genetic association studies in pharmacogenetics, including a framework for working with healthy volunteers. The basic approach for case—control studies is to compare the genetic makeup of populations of patients with different response profiles. We describe how recent studies of the pattern of linkage disequilibrium in the human genome have led to the idea of using a subset of tagging single nucleotide polymorphisms (SNPs) to represent the common haplotypes within a population. This approach greatly reduces the economic costs of association studies and allows consideration of multiple candidate genes. Many drugs target multigenic pathways, e.g. the renin—angiotensin system (RAS), and it is desirable to include all the components of the pathway in pharmacogenetic studies. We also compare the candidate gene approach and a whole genome scanning approach and argue that even in the future, when whole genome scans become feasible, in most cases a candidate gene approach will still be the preferred method. Finally, we emphasize that finding an association is only the beginning and there are many steps before information from an association study can be used diagnostically in the clinic." @default.
• W168114416 created "2016-06-24" @default.
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• W168114416 date "2004-01-01" @default.
• W168114416 modified "2023-09-27" @default.
• W168114416 title "Pharmacogenetics and the Treatment of Cardiovascular Disease" @default.
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• W168114416 doi "https://doi.org/10.1007/978-3-662-06214-2_2" @default.
• W168114416 hasPublicationYear "2004" @default.
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