FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W168175021> ?p ?o ?g. }

• W168175021 endingPage "67" @default.
• W168175021 startingPage "357" @default.
• W168175021 abstract "We determined the quantitative and topographic distribution of gamma/delta lymphocytes in normal human lymphoid tissue and peripheral blood using a monoclonal antibody that detects a framework determinant on delta molecules and delineated the immunophenotypic characteristics of the gamma/delta lymphocyte population by one- and/or two-color immunohistochemical and two- and/or three-color flow cytometric analysis. Variable, but generally small, numbers of gamma/delta lymphocytes are present in peripheral blood and in all lymphoid tissues. The vast majority, greater than or equal to 90%, of lymphoid tissue delta lymphocytes reside in interfollicular (T-cell) zones. Approximately 90% of delta thymocytes are present in the thymic medulla. The percentage of CD3-positive T cells that express delta are: spleen 12.5 +/- 8.1%, peripheral blood 4.0 +/- 3.1%, appendix 2.9 +/- 1%, lymph node 2.2 +/- 1%, thymus 1.4 +/- 0.5%, and tonsil 0.7 +/- 0.5%. We further demonstrated that 1) gamma/delta-thymocytes and gamma/delta peripheral lymphocytes express T-cell lineage restricted antigens CD3 and CD2 but only a variable subset, 30% to 90%, express T-cell lineage associated antigens CD5 and/or CD8; (2) approximately 60% of gamma/delta thymocytes express low-density CD4 while all gamma/delta peripheral lymphocytes lack detectable CD4; 3) gamma/delta lymphocytes lack natural killer (NK), macrophage, and B-cell associated antigens CD16, CD14, and CD20, respectively, but greater than or equal to 70% of gamma/delta T lymphocytes express CD11b, Leu7, and NKH-1, antigens, which are also expressed by suppressor/cytotoxic and NK cells; and 4) a large subpopulation, approximately 25%, of gamma/delta thymocytes are in S1-G2 phase, while greater than or equal to 98% of gamma/delta peripheral lymphocytes are small lymphocytes in G0-G1 phase and lack activation/proliferation markers. Together these results indicate that gamma/delta lymphocytes are resting, mature T cells that probably play a primary role in suppressor/cytotoxic phenomena. They also indicate that gamma/delta lymphocytes variably express multiple-cell surface antigens associated with various cell lineages, suggesting that gamma/delta lymphocytes represent a considerably more heterogeneous cell population than previously appreciated and that they may actually subserve multiple functions." @default.
• W168175021 created "2016-06-24" @default.
• W168175021 creator A5006640724 @default.
• W168175021 creator A5045638230 @default.
• W168175021 creator A5046153371 @default.
• W168175021 creator A5079620168 @default.
• W168175021 date "1990-02-01" @default.
• W168175021 modified "2023-09-24" @default.
• W168175021 title "Flow cytometric and immunohistochemical characterization of the gamma/delta T-lymphocyte population in normal human lymphoid tissue and peripheral blood." @default.
• W168175021 cites W1462658072 @default.
• W168175021 cites W1500160410 @default.
• W168175021 cites W1505667323 @default.
• W168175021 cites W1556356166 @default.
• W168175021 cites W1558434765 @default.
• W168175021 cites W1586561401 @default.
• W168175021 cites W171001763 @default.
• W168175021 cites W1804396352 @default.
• W168175021 cites W1927268230 @default.
• W168175021 cites W1958125141 @default.
• W168175021 cites W1971691485 @default.
• W168175021 cites W1990871255 @default.
• W168175021 cites W1997056931 @default.
• W168175021 cites W2016249716 @default.
• W168175021 cites W2016945436 @default.
• W168175021 cites W2020851010 @default.
• W168175021 cites W2033010633 @default.
• W168175021 cites W2036509722 @default.
• W168175021 cites W2053788986 @default.
• W168175021 cites W2058838915 @default.
• W168175021 cites W2062057016 @default.
• W168175021 cites W2065249968 @default.
• W168175021 cites W2070408890 @default.
• W168175021 cites W2072418891 @default.
• W168175021 cites W2082919075 @default.
• W168175021 cites W2084990440 @default.
• W168175021 cites W2089489766 @default.
• W168175021 cites W2092450783 @default.
• W168175021 cites W2097231057 @default.
• W168175021 cites W2106719152 @default.
• W168175021 cites W2107812706 @default.
• W168175021 cites W2108007089 @default.
• W168175021 cites W2116643151 @default.
• W168175021 cites W2126486896 @default.
• W168175021 cites W2134297634 @default.
• W168175021 cites W2169790726 @default.
• W168175021 cites W2173828780 @default.
• W168175021 cites W400561 @default.
• W168175021 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1877417" @default.
• W168175021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2137673" @default.
• W168175021 hasPublicationYear "1990" @default.
• W168175021 type Work @default.
• W168175021 sameAs 168175021 @default.
• W168175021 citedByCount "33" @default.
• W168175021 countsByYear W1681750212012 @default.
• W168175021 countsByYear W1681750212017 @default.
• W168175021 countsByYear W1681750212019 @default.
• W168175021 countsByYear W1681750212022 @default.
• W168175021 countsByYear W1681750212023 @default.
• W168175021 crossrefType "journal-article" @default.
• W168175021 hasAuthorship W168175021A5006640724 @default.
• W168175021 hasAuthorship W168175021A5045638230 @default.
• W168175021 hasAuthorship W168175021A5046153371 @default.
• W168175021 hasAuthorship W168175021A5079620168 @default.
• W168175021 hasConcept C113067387 @default.
• W168175021 hasConcept C114684123 @default.
• W168175021 hasConcept C142724271 @default.
• W168175021 hasConcept C147483822 @default.
• W168175021 hasConcept C153911025 @default.
• W168175021 hasConcept C167672396 @default.
• W168175021 hasConcept C181152851 @default.
• W168175021 hasConcept C203014093 @default.
• W168175021 hasConcept C2776090121 @default.
• W168175021 hasConcept C2777761686 @default.
• W168175021 hasConcept C2908647359 @default.
• W168175021 hasConcept C2992881475 @default.
• W168175021 hasConcept C71924100 @default.
• W168175021 hasConcept C86803240 @default.
• W168175021 hasConcept C8891405 @default.
• W168175021 hasConcept C99454951 @default.
• W168175021 hasConceptScore W168175021C113067387 @default.
• W168175021 hasConceptScore W168175021C114684123 @default.
• W168175021 hasConceptScore W168175021C142724271 @default.
• W168175021 hasConceptScore W168175021C147483822 @default.
• W168175021 hasConceptScore W168175021C153911025 @default.
• W168175021 hasConceptScore W168175021C167672396 @default.
• W168175021 hasConceptScore W168175021C181152851 @default.
• W168175021 hasConceptScore W168175021C203014093 @default.
• W168175021 hasConceptScore W168175021C2776090121 @default.
• W168175021 hasConceptScore W168175021C2777761686 @default.
• W168175021 hasConceptScore W168175021C2908647359 @default.
• W168175021 hasConceptScore W168175021C2992881475 @default.
• W168175021 hasConceptScore W168175021C71924100 @default.
• W168175021 hasConceptScore W168175021C86803240 @default.
• W168175021 hasConceptScore W168175021C8891405 @default.
• W168175021 hasConceptScore W168175021C99454951 @default.
• W168175021 hasIssue "2" @default.
• W168175021 hasLocation W1681750211 @default.
• W168175021 hasOpenAccess W168175021 @default.

• next