Matches in SemOpenAlex for { <https://semopenalex.org/work/W1682207880> ?p ?o ?g. }
- W1682207880 endingPage "2284" @default.
- W1682207880 startingPage "2274" @default.
- W1682207880 abstract "The chemokine CCL11 (also known as eotaxin-1) is a potent eosinophil chemoattractant that mediates allergic diseases such as asthma, atopic dermatitis, and inflammatory bowel diseases. Previous studies demonstrated that concentrations of CCL11 are elevated in the sera and cerebrospinal fluids (CSF) of patients with neuroinflammatory disorders, including multiple sclerosis. Moreover, the levels of CCL11 in plasma and CSF increase with age, and CCL11 suppresses adult neurogenesis in the central nervous system (CNS), resulting in memory impairment. However, the precise source and function of CCL11 in the CNS are not fully understood. In this study, we found that activated astrocytes release CCL11, whereas microglia predominantly express the CCL11 receptor. CCL11 significantly promoted the migration of microglia, and induced microglial production of reactive oxygen species by upregulating nicotinamide adenine dinucleotide phosphate-oxidase 1 (NOX1), thereby promoting excitotoxic neuronal death. These effects were reversed by inhibition of NOX1. Our findings suggest that CCL11 released from activated astrocytes triggers oxidative stress via microglial NOX1 activation and potentiates glutamate-mediated neurotoxicity, which may be involved in the pathogenesis of various neurological disorders." @default.
- W1682207880 created "2016-06-24" @default.
- W1682207880 creator A5040626070 @default.
- W1682207880 creator A5044126659 @default.
- W1682207880 creator A5069337032 @default.
- W1682207880 creator A5073478065 @default.
- W1682207880 creator A5075889151 @default.
- W1682207880 date "2015-07-17" @default.
- W1682207880 modified "2023-10-10" @default.
- W1682207880 title "CCL11 enhances excitotoxic neuronal death by producing reactive oxygen species in microglia" @default.
- W1682207880 cites W1561228697 @default.
- W1682207880 cites W1593528517 @default.
- W1682207880 cites W1925963149 @default.
- W1682207880 cites W1969905245 @default.
- W1682207880 cites W1973190148 @default.
- W1682207880 cites W1975164266 @default.
- W1682207880 cites W1975896989 @default.
- W1682207880 cites W1977313312 @default.
- W1682207880 cites W1977604451 @default.
- W1682207880 cites W1987362442 @default.
- W1682207880 cites W1988016557 @default.
- W1682207880 cites W1992987846 @default.
- W1682207880 cites W1994254814 @default.
- W1682207880 cites W2000303645 @default.
- W1682207880 cites W2000420483 @default.
- W1682207880 cites W2001728189 @default.
- W1682207880 cites W2004216239 @default.
- W1682207880 cites W2004349171 @default.
- W1682207880 cites W2008113816 @default.
- W1682207880 cites W2008423294 @default.
- W1682207880 cites W2009133237 @default.
- W1682207880 cites W2013132903 @default.
- W1682207880 cites W2014495235 @default.
- W1682207880 cites W2017079337 @default.
- W1682207880 cites W2032618901 @default.
- W1682207880 cites W2037324465 @default.
- W1682207880 cites W2039980834 @default.
- W1682207880 cites W2042452988 @default.
- W1682207880 cites W2043219898 @default.
- W1682207880 cites W2045262404 @default.
- W1682207880 cites W2047245618 @default.
- W1682207880 cites W2050048961 @default.
- W1682207880 cites W2054790952 @default.
- W1682207880 cites W2056122772 @default.
- W1682207880 cites W2061660439 @default.
- W1682207880 cites W2073607297 @default.
- W1682207880 cites W2074472141 @default.
- W1682207880 cites W2075464971 @default.
- W1682207880 cites W2078865976 @default.
- W1682207880 cites W2080609849 @default.
- W1682207880 cites W2083286809 @default.
- W1682207880 cites W2090804892 @default.
- W1682207880 cites W2091043188 @default.
- W1682207880 cites W2093493917 @default.
- W1682207880 cites W2097292535 @default.
- W1682207880 cites W2123779560 @default.
- W1682207880 cites W2128584846 @default.
- W1682207880 cites W2130782339 @default.
- W1682207880 cites W2143479333 @default.
- W1682207880 cites W2144264857 @default.
- W1682207880 cites W2146546145 @default.
- W1682207880 cites W2151306715 @default.
- W1682207880 cites W2157329817 @default.
- W1682207880 cites W2160427694 @default.
- W1682207880 cites W2164768012 @default.
- W1682207880 cites W2168025729 @default.
- W1682207880 cites W2168315986 @default.
- W1682207880 cites W2169028987 @default.
- W1682207880 cites W2172005240 @default.
- W1682207880 cites W4229548424 @default.
- W1682207880 cites W4234072569 @default.
- W1682207880 cites W4240211429 @default.
- W1682207880 cites W72465079 @default.
- W1682207880 doi "https://doi.org/10.1002/glia.22892" @default.
- W1682207880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26184677" @default.
- W1682207880 hasPublicationYear "2015" @default.
- W1682207880 type Work @default.
- W1682207880 sameAs 1682207880 @default.
- W1682207880 citedByCount "100" @default.
- W1682207880 countsByYear W16822078802015 @default.
- W1682207880 countsByYear W16822078802016 @default.
- W1682207880 countsByYear W16822078802017 @default.
- W1682207880 countsByYear W16822078802018 @default.
- W1682207880 countsByYear W16822078802019 @default.
- W1682207880 countsByYear W16822078802020 @default.
- W1682207880 countsByYear W16822078802021 @default.
- W1682207880 countsByYear W16822078802022 @default.
- W1682207880 countsByYear W16822078802023 @default.
- W1682207880 crossrefType "journal-article" @default.
- W1682207880 hasAuthorship W1682207880A5040626070 @default.
- W1682207880 hasAuthorship W1682207880A5044126659 @default.
- W1682207880 hasAuthorship W1682207880A5069337032 @default.
- W1682207880 hasAuthorship W1682207880A5073478065 @default.
- W1682207880 hasAuthorship W1682207880A5075889151 @default.
- W1682207880 hasConcept C13373296 @default.
- W1682207880 hasConcept C136834591 @default.
- W1682207880 hasConcept C169760540 @default.
- W1682207880 hasConcept C203014093 @default.