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W168223604 endingPage "225" @default.
W168223604 startingPage "201" @default.
W168223604 abstract "Publisher Summary This chapter discusses the role of phosphoribosyltransferases in purine metabolism. Its role in purine metabolism cannot be adequately described by their presumed function solely as salvage enzymes. The substrates or products of the phosphoribosyltransferase reactions are directly involved in a variety of different but interdependent mechanisms that regulate mammalian purine synthesis de novo or from preformed purine bases, the interconversions of nucleotides, and the pathways of purine degradation. The excessive purine synthesis associated with the deficiency of HPRT in man, X-linked uric aciduria, demonstrates an important role for this enzyme in the regulation of the rate of the de novo pathway of synthesis. This mutation has provided an approach to the study of many aspects of purine metabolism, as well as some of the more general problems of human biochemical genetics." @default.
W168223604 created "2016-06-24" @default.
W168223604 creator A5037864999 @default.
W168223604 creator A5040675882 @default.
W168223604 date "1970-01-01" @default.
W168223604 modified "2023-09-26" @default.
W168223604 title "The Role of Phosphoribosyltransferases in Purine Metabolism" @default.
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