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- W168305955 abstract "The vasoactive intestinal peptide (VIP) is 28 amino acid neuropeptide which has a wide distribution in peripheral and central nervous systems and a large spectrum of biological actions in mammals. VIP actions are mediated through specific G protein-coupled receptors; VPAC1 and VPAC2. The synaptic scaffolding molecule S-SCAM/MAGI2 is an adaptor protein which has six PDZ domains (PDZ0 to PDZ5), one GK domain, and two WW domains. Using yeast-two-hybrid assay, it was found that PDZ1 and PDZ2 domains of rat S-SCAM/MAGI-2 interact with the C-terminus of mouse VIP receptor 1 (VPAC1). The S-SCAM-VPAC1 interaction was also verified by co-immunoprecipitation in HEK293 cells with heterologous expressions. To examine the effect of S-SCAM/MAGI-2 on the surface expression of VPAC1, the surface biotinylation assay and surface immunocytochemistry were performed. Interestingly, VPAC1 expression on plasma membrane was increased by S-SCAM/MAGI-2. VPAC1 is coupled to Gs proteins and the activation of VPAC1 by ligand binding increases the intracellular concentration of cAMP. Accordingly, overexpression of S-SCAM altered cellular responses evoked by VPAC1 stimulations through cAMP/PKA signals. These results suggest that S-SCAM/MAGI-2 binds to and regulates the activity of VPAC1. (This study was supported by grant E00067 from the Korea Research Foundation.)" @default.
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- W168305955 date "2007-01-01" @default.
- W168305955 modified "2023-09-26" @default.
- W168305955 title "Biochemical and Functional Interaction between VPAC1 and S‐SCAM/MAGI‐2" @default.
- W168305955 doi "https://doi.org/10.1096/fasebj.21.6.a1322" @default.
- W168305955 hasPublicationYear "2007" @default.
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