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- W168317785 abstract "Caveolin-3 (Cav-3) is expressed predominantly in skeletal muscle fibers where it drives Caveolae formation at the muscle cell's plasma membrane (sarcolemma). We and others have previously shown that mice with a genetic ablation of Cav-3 develop glucose intolerance, insulin resistance, and obesity. The main objective of this study is to determine the effect of Cav-3 ablation on whole-body/tissue lipid metabolism. To address this issue, several metabolic parameters were analyzed in the plasma of young and older Cav-3 KO mice. In addition, by employing radiolabeled metabolic substrates, we directly determined the contribution of skeletal muscle to the plasma dyslipidemia of Cav-3 KO mice. In summary, the current study shows that an absence of Cav-3 leads to dyslipidemia in mice. The primary defect can be localized to the skeletal muscle and is secondary to altered muscle substrate utilization caused by Cav-3 ablation. Support: American Heart Association; BGIA" @default.
- W168317785 created "2016-06-24" @default.
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- W168317785 date "2009-04-01" @default.
- W168317785 modified "2023-09-25" @default.
- W168317785 title "Caveolin‐3 KO Mice Develop Dyslipidemia with Impaired Substrate Utilization in Skeletal Muscle." @default.
- W168317785 doi "https://doi.org/10.1096/fasebj.23.1_supplement.600.32" @default.
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