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- W1683575640 abstract "Genetic improvement of l -leucine productivity in strain 218, an ile − 2-thiazolealanine-resistant mutant of Brevibacterium lactofermentum 2256, was attempted. In strain 218, which produced 28 mg of l -leucine per ml from 13% glucose, α-isopropylmalate synthetase was genetically desensitized and derepressed to the effect of l -leucine, whereas α-acetohydroxy acid synthetase remained unaltered, although it could be derepressed phenotypically by limiting the isoleucine concentration in the culture. From strain 218 we isolated 103 mutants resistant to β-hydroxyleucine (4 mg/ml). Among these, three were found to produce mere l -leucine than the parent. The α-acetohydroxy acid synthetase of all three mutant strains was found to be genetically desensitized to all of the branched-chain amino acids l -isoleucine, l -valine, and l -leucine. The repression mechanism in α-acetohydroxy acid synthetase formation was the same as in the parent strain. The improved strains typically produced 34 mg of l -leucine per ml, the highest productivity ever reported." @default.
- W1683575640 created "2016-06-24" @default.
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- W1683575640 date "1986-05-01" @default.
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- W1683575640 title "Improvement of an <scp>l</scp> -Leucine-Producing Mutant of <i>Brevibacterium lactofermentum</i> 2256 by Genetically Desensitizing It to α-Acetohydroxy Acid Synthetase" @default.
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- W1683575640 doi "https://doi.org/10.1128/aem.51.5.1024-1027.1986" @default.
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