Matches in SemOpenAlex for { <https://semopenalex.org/work/W1683841982> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W1683841982 abstract "The purpose of this study was to evaluate whether administration of a proteasome inhibitor (MG-132) in vivo is able to prevent muscle atrophy caused by hindlimb unloading (HU). Twenty-seven NMRI mice were assigned to a weight-bearing control, a 6-day HU or a 6-day HU+MG-132 (1mg/kg/48h) treatment group. Soleus (SOL), gastrocnemius (GAS) and tibialis anterior (TA) muscles were removed and weighed. After HU muscle wasting was 20% in SOL, 7% in TA and 13% in GAS (P<0.05). MG-132 treatment prevented 50% of atrophy induced by HU in GAS only (P<0.05). In this muscle, HU was associated with an increased expression of MuRF-1 (P<0.05), Atrogin-1 (P<0.05) and myostatin mRNA (P<0.055), whereas E3α, Nedd-4 and IL-6 remained unchanged. A 19% increase in chymotrypsin-like proteasomal activity was observed in HU (P<0.05) but not in HU+MG-132 GAS. Interestingly, a repression of MurF-1 and myostatin mRNA was also observed with MG-132. In TA, pro-caspase-3 cytosolic expression was decreased by 60% with HU (P<0.05) and only by 20% with HU+MG-132 (P<0.05). These results suggest that in vivo administration of MG-132 can prevent partially muscle atrophy associated with disuse, but that this effect is not specific of a proteasome activity inhibition." @default.
- W1683841982 created "2016-06-24" @default.
- W1683841982 creator A5001010398 @default.
- W1683841982 creator A5006124607 @default.
- W1683841982 creator A5060567040 @default.
- W1683841982 creator A5077988213 @default.
- W1683841982 date "2009-01-01" @default.
- W1683841982 modified "2023-09-27" @default.
- W1683841982 title "EFFECT OF PROTEASOME INHIBITOR MG-132 ON MUSCLE DISUSE ATROPHY" @default.
- W1683841982 hasPublicationYear "2009" @default.
- W1683841982 type Work @default.
- W1683841982 sameAs 1683841982 @default.
- W1683841982 citedByCount "0" @default.
- W1683841982 crossrefType "journal-article" @default.
- W1683841982 hasAuthorship W1683841982A5001010398 @default.
- W1683841982 hasAuthorship W1683841982A5006124607 @default.
- W1683841982 hasAuthorship W1683841982A5060567040 @default.
- W1683841982 hasAuthorship W1683841982A5077988213 @default.
- W1683841982 hasConcept C126322002 @default.
- W1683841982 hasConcept C134018914 @default.
- W1683841982 hasConcept C150903083 @default.
- W1683841982 hasConcept C185592680 @default.
- W1683841982 hasConcept C207001950 @default.
- W1683841982 hasConcept C2776104385 @default.
- W1683841982 hasConcept C2776263037 @default.
- W1683841982 hasConcept C2777488582 @default.
- W1683841982 hasConcept C2779764123 @default.
- W1683841982 hasConcept C2779959927 @default.
- W1683841982 hasConcept C2781172350 @default.
- W1683841982 hasConcept C51738704 @default.
- W1683841982 hasConcept C71924100 @default.
- W1683841982 hasConcept C86803240 @default.
- W1683841982 hasConceptScore W1683841982C126322002 @default.
- W1683841982 hasConceptScore W1683841982C134018914 @default.
- W1683841982 hasConceptScore W1683841982C150903083 @default.
- W1683841982 hasConceptScore W1683841982C185592680 @default.
- W1683841982 hasConceptScore W1683841982C207001950 @default.
- W1683841982 hasConceptScore W1683841982C2776104385 @default.
- W1683841982 hasConceptScore W1683841982C2776263037 @default.
- W1683841982 hasConceptScore W1683841982C2777488582 @default.
- W1683841982 hasConceptScore W1683841982C2779764123 @default.
- W1683841982 hasConceptScore W1683841982C2779959927 @default.
- W1683841982 hasConceptScore W1683841982C2781172350 @default.
- W1683841982 hasConceptScore W1683841982C51738704 @default.
- W1683841982 hasConceptScore W1683841982C71924100 @default.
- W1683841982 hasConceptScore W1683841982C86803240 @default.
- W1683841982 hasLocation W16838419821 @default.
- W1683841982 hasOpenAccess W1683841982 @default.
- W1683841982 hasPrimaryLocation W16838419821 @default.
- W1683841982 hasRelatedWork W1768572657 @default.
- W1683841982 hasRelatedWork W2061276730 @default.
- W1683841982 hasRelatedWork W2074016706 @default.
- W1683841982 hasRelatedWork W2110987190 @default.
- W1683841982 hasRelatedWork W2152862580 @default.
- W1683841982 hasRelatedWork W2155609332 @default.
- W1683841982 hasRelatedWork W2188383379 @default.
- W1683841982 hasRelatedWork W2212921014 @default.
- W1683841982 hasRelatedWork W2402540524 @default.
- W1683841982 hasRelatedWork W2750574847 @default.
- W1683841982 hasRelatedWork W2891945200 @default.
- W1683841982 hasRelatedWork W2897540505 @default.
- W1683841982 hasRelatedWork W2897898396 @default.
- W1683841982 hasRelatedWork W2911244367 @default.
- W1683841982 hasRelatedWork W2937796648 @default.
- W1683841982 hasRelatedWork W2943254757 @default.
- W1683841982 hasRelatedWork W3016357831 @default.
- W1683841982 hasRelatedWork W3083349290 @default.
- W1683841982 hasRelatedWork W3174119254 @default.
- W1683841982 hasRelatedWork W388311862 @default.
- W1683841982 isParatext "false" @default.
- W1683841982 isRetracted "false" @default.
- W1683841982 magId "1683841982" @default.
- W1683841982 workType "article" @default.