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- W1684615798 abstract "20( S )‐Protopanaxadiol is a natural product found in ginseng and notoginseng. It exhibited a wide range of pharmacological properties, including antiestrogenic, anti‐inflammatory, antitumor, vasodilator, and antinociceptive. The in vitro metabolism of 20( S )‐protopanaxadiol was studied in human liver microsomes and human hepatocytes. The initial and primary metabolic pathway was epoxidation of the 24,25‐double bond to generate 24,25‐epoxides ( 2 and 3 ), followed by hydration reaction to yield the corresponding 24,25‐vicinal diol derivatives ( 4 and 5 ) and hydration/ring closure to yield 20,24‐oxide ( 6 and 7 ). Metabolites 6 and 7 underwent dehydrogenation to form ketones, and hydroxylation and conjugation reactions to yield numerous secondary metabolites. In addition, two glucuronide conjugates were detected in human hepatocytes incubation." @default.
- W1684615798 created "2016-06-24" @default.
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- W1684615798 date "2013-10-13" @default.
- W1684615798 modified "2023-09-23" @default.
- W1684615798 title "20( <i>S</i> )‐Protopanaxadiol" @default.
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- W1684615798 doi "https://doi.org/10.1002/9781118541203.xen478" @default.
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