Matches in SemOpenAlex for { <https://semopenalex.org/work/W1684656761> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1684656761 endingPage "H190" @default.
- W1684656761 startingPage "H183" @default.
- W1684656761 abstract "The energetics of the senescent (S) rat heart and the mechanisms by which it adapts to pressure overload have been investigated by simultaneous cardiac mechanical, energetic, and molecular biological studies. Compared with young adult (YA), S papillary muscles had an improved economy of contraction since the curvature (G) of Hill's (Proc. R. Soc. Lond. B. Biol. Sci. 126:136–195, 1938) hyperbola was increased (S, 1.93 +/- 0.13; YA, 1.60 +/- 0.07, P < 0.05). In addition, the maximum unloaded shortening (Vmax) and relengthening velocities were both reduced in S. In parallel, both alpha-myosin heavy chain (MHC) and sarcoplasmic reticulum (SR) Ca(2+)-adenosinetriphosphatase (ATPase) mRNA contents were reduced (-30 and -28%, respectively), whereas beta-MHC mRNA was increased (+91%). The active tension (S, 40.0 +/- 2.6; YA, 50.1 +/- 2.5 mN/mm2, P < 0.01) was depressed although the active force remained unchanged (S, 52.0 +/- 4.0; YA, 47.5 +/- 2.5 mN). Pressure overload in senescent deoxycorticosterone acetate (DOCA)-salt rats induced a left ventricular hypertrophy (+43%) and a further decrease in both Vmax (S, 2.81 +/- 0.10; DOCA-salt, 2.55 +/- 0.13 initial length corresponding to peak of length-active curve/s, P < 0.05) and alpha-MHC mRNA (-30%) content. Senescence modifies mechanics and gene expression in a way similar to pressure overload. During senescence, an additional overload induces left ventricular hypertrophy and attenuates Vmax without worsening the economy of the contraction." @default.
- W1684656761 created "2016-06-24" @default.
- W1684656761 creator A5029193905 @default.
- W1684656761 creator A5031198626 @default.
- W1684656761 creator A5035293082 @default.
- W1684656761 creator A5054480556 @default.
- W1684656761 creator A5056043654 @default.
- W1684656761 creator A5072884577 @default.
- W1684656761 creator A5079794318 @default.
- W1684656761 date "1993-07-01" @default.
- W1684656761 modified "2023-09-25" @default.
- W1684656761 title "Normal and hypertrophied senescent rat heart: mechanical and molecular characteristics" @default.
- W1684656761 doi "https://doi.org/10.1152/ajpheart.1993.265.1.h183" @default.
- W1684656761 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8342633" @default.
- W1684656761 hasPublicationYear "1993" @default.
- W1684656761 type Work @default.
- W1684656761 sameAs 1684656761 @default.
- W1684656761 citedByCount "35" @default.
- W1684656761 countsByYear W16846567612012 @default.
- W1684656761 countsByYear W16846567612013 @default.
- W1684656761 countsByYear W16846567612015 @default.
- W1684656761 countsByYear W16846567612020 @default.
- W1684656761 crossrefType "journal-article" @default.
- W1684656761 hasAuthorship W1684656761A5029193905 @default.
- W1684656761 hasAuthorship W1684656761A5031198626 @default.
- W1684656761 hasAuthorship W1684656761A5035293082 @default.
- W1684656761 hasAuthorship W1684656761A5054480556 @default.
- W1684656761 hasAuthorship W1684656761A5056043654 @default.
- W1684656761 hasAuthorship W1684656761A5072884577 @default.
- W1684656761 hasAuthorship W1684656761A5079794318 @default.
- W1684656761 hasConcept C126322002 @default.
- W1684656761 hasConcept C134018914 @default.
- W1684656761 hasConcept C158617107 @default.
- W1684656761 hasConcept C163415756 @default.
- W1684656761 hasConcept C167414201 @default.
- W1684656761 hasConcept C181199279 @default.
- W1684656761 hasConcept C185592680 @default.
- W1684656761 hasConcept C23265538 @default.
- W1684656761 hasConcept C2778271984 @default.
- W1684656761 hasConcept C3018791406 @default.
- W1684656761 hasConcept C522857546 @default.
- W1684656761 hasConcept C53009064 @default.
- W1684656761 hasConcept C55493867 @default.
- W1684656761 hasConcept C71924100 @default.
- W1684656761 hasConcept C86803240 @default.
- W1684656761 hasConceptScore W1684656761C126322002 @default.
- W1684656761 hasConceptScore W1684656761C134018914 @default.
- W1684656761 hasConceptScore W1684656761C158617107 @default.
- W1684656761 hasConceptScore W1684656761C163415756 @default.
- W1684656761 hasConceptScore W1684656761C167414201 @default.
- W1684656761 hasConceptScore W1684656761C181199279 @default.
- W1684656761 hasConceptScore W1684656761C185592680 @default.
- W1684656761 hasConceptScore W1684656761C23265538 @default.
- W1684656761 hasConceptScore W1684656761C2778271984 @default.
- W1684656761 hasConceptScore W1684656761C3018791406 @default.
- W1684656761 hasConceptScore W1684656761C522857546 @default.
- W1684656761 hasConceptScore W1684656761C53009064 @default.
- W1684656761 hasConceptScore W1684656761C55493867 @default.
- W1684656761 hasConceptScore W1684656761C71924100 @default.
- W1684656761 hasConceptScore W1684656761C86803240 @default.
- W1684656761 hasIssue "1" @default.
- W1684656761 hasLocation W16846567611 @default.
- W1684656761 hasLocation W16846567612 @default.
- W1684656761 hasLocation W16846567613 @default.
- W1684656761 hasOpenAccess W1684656761 @default.
- W1684656761 hasPrimaryLocation W16846567611 @default.
- W1684656761 hasRelatedWork W1979139803 @default.
- W1684656761 hasRelatedWork W1981654342 @default.
- W1684656761 hasRelatedWork W1986178764 @default.
- W1684656761 hasRelatedWork W1993394218 @default.
- W1684656761 hasRelatedWork W2029120861 @default.
- W1684656761 hasRelatedWork W2103364644 @default.
- W1684656761 hasRelatedWork W2159629462 @default.
- W1684656761 hasRelatedWork W2326989446 @default.
- W1684656761 hasRelatedWork W2379924765 @default.
- W1684656761 hasRelatedWork W2748952813 @default.
- W1684656761 hasVolume "265" @default.
- W1684656761 isParatext "false" @default.
- W1684656761 isRetracted "false" @default.
- W1684656761 magId "1684656761" @default.
- W1684656761 workType "article" @default.