FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1684751467> ?p ?o ?g. }

• W1684751467 endingPage "305" @default.
• W1684751467 startingPage "305" @default.
• W1684751467 abstract "Methylation as an epigenetic source of random genetic effects in the classical twin design Conor V Dolan,1,3 Michel G Nivard,1,3 Jenny van Dongen,1,3 Sophie van der Sluis,2 Dorret I Boomsma,1,3,4 1Department of Biological Psychology, Netherlands Twin Register, VU University Amsterdam, 2Section Complex Trait Genetics, Department of Clinical Genetics, VU Medical Center, 3EMGO+ Institute for Health and Care Research, VU University Medical Center, 4Neuroscience Campus Amsterdam, Amsterdam, the Netherlands Abstract: The epigenetic effects of cytosine methylation on gene expression are an acknowledged source of phenotypic variance. The discordant monozygotic (MZ) twin design has been used to demonstrate the role of methylation in disease. Application of the classical twin design, featuring both monozygotic and dizygotic twins, has demonstrated that individual differences in methylation levels are attributable to genetic and environmental (including stochastic) factors, with the latter explaining most of the variance. What implications epigenetic sources of variance have for the twin modeling of (non-epigenetic) phenotypes such as height and IQ is an open question. One possibility is that epigenetic effects are absorbed by the variance component attributable to unshared environmental. Another possibility is that such effects form an independent source of variance distinguishable in principle from standard genetic and environmental sources. In the present paper, we conceptualized epigenetic processes as giving rise to randomness in the effects of polygenetic influences. This means that the regression coefficient in the regression of the phenotype on the polygenic factor, as specified in the twin model, varies over individuals. We investigate the consequences of ignoring this randomness in the standard twin model. Keywords: classical twin design, epigenetics, methylation, parameter randomness, heritability" @default.
• W1684751467 created "2016-06-24" @default.
• W1684751467 creator A5008837404 @default.
• W1684751467 creator A5020294117 @default.
• W1684751467 creator A5033802658 @default.
• W1684751467 creator A5075112556 @default.
• W1684751467 creator A5079752137 @default.
• W1684751467 date "2015-09-01" @default.
• W1684751467 modified "2023-10-16" @default.
• W1684751467 title "Methylation as an epigenetic source of random genetic effects in the classical twin design" @default.
• W1684751467 cites W1524341491 @default.
• W1684751467 cites W1563196241 @default.
• W1684751467 cites W1588316525 @default.
• W1684751467 cites W1682796668 @default.
• W1684751467 cites W1965273068 @default.
• W1684751467 cites W1974751720 @default.
• W1684751467 cites W1990706764 @default.
• W1684751467 cites W1992150627 @default.
• W1684751467 cites W1997887791 @default.
• W1684751467 cites W1999860818 @default.
• W1684751467 cites W2004646826 @default.
• W1684751467 cites W2004880902 @default.
• W1684751467 cites W2007083875 @default.
• W1684751467 cites W2008978345 @default.
• W1684751467 cites W2012974517 @default.
• W1684751467 cites W2021480557 @default.
• W1684751467 cites W2024613932 @default.
• W1684751467 cites W2031597554 @default.
• W1684751467 cites W2031724786 @default.
• W1684751467 cites W2033151532 @default.
• W1684751467 cites W2051015664 @default.
• W1684751467 cites W2052208159 @default.
• W1684751467 cites W2052506025 @default.
• W1684751467 cites W2053065690 @default.
• W1684751467 cites W2064851646 @default.
• W1684751467 cites W2065020285 @default.
• W1684751467 cites W2067645578 @default.
• W1684751467 cites W2068853666 @default.
• W1684751467 cites W2076154138 @default.
• W1684751467 cites W2084076990 @default.
• W1684751467 cites W2085126855 @default.
• W1684751467 cites W2092806227 @default.
• W1684751467 cites W2093299566 @default.
• W1684751467 cites W2096206611 @default.
• W1684751467 cites W2098405376 @default.
• W1684751467 cites W2100963504 @default.
• W1684751467 cites W2102893853 @default.
• W1684751467 cites W2110941726 @default.
• W1684751467 cites W2114178217 @default.
• W1684751467 cites W2117007075 @default.
• W1684751467 cites W2121417064 @default.
• W1684751467 cites W2123032740 @default.
• W1684751467 cites W2125700595 @default.
• W1684751467 cites W2125984352 @default.
• W1684751467 cites W2130907138 @default.
• W1684751467 cites W2134555277 @default.
• W1684751467 cites W2134803671 @default.
• W1684751467 cites W2135241232 @default.
• W1684751467 cites W2135842170 @default.
• W1684751467 cites W2137815533 @default.
• W1684751467 cites W2141088880 @default.
• W1684751467 cites W2141470108 @default.
• W1684751467 cites W2143086385 @default.
• W1684751467 cites W2146680808 @default.
• W1684751467 cites W2147961966 @default.
• W1684751467 cites W2151094911 @default.
• W1684751467 cites W2151193284 @default.
• W1684751467 cites W2158320244 @default.
• W1684751467 cites W2159194460 @default.
• W1684751467 cites W2160074632 @default.
• W1684751467 cites W2162290916 @default.
• W1684751467 cites W2167265200 @default.
• W1684751467 cites W2167996825 @default.
• W1684751467 cites W2170634666 @default.
• W1684751467 cites W2171369698 @default.
• W1684751467 cites W2798043078 @default.
• W1684751467 cites W2951214768 @default.
• W1684751467 doi "https://doi.org/10.2147/agg.s46909" @default.
• W1684751467 hasPublicationYear "2015" @default.
• W1684751467 type Work @default.
• W1684751467 sameAs 1684751467 @default.
• W1684751467 citedByCount "1" @default.
• W1684751467 countsByYear W16847514672017 @default.
• W1684751467 crossrefType "journal-article" @default.
• W1684751467 hasAuthorship W1684751467A5008837404 @default.
• W1684751467 hasAuthorship W1684751467A5020294117 @default.
• W1684751467 hasAuthorship W1684751467A5033802658 @default.
• W1684751467 hasAuthorship W1684751467A5075112556 @default.
• W1684751467 hasAuthorship W1684751467A5079752137 @default.
• W1684751467 hasBestOaLocation W16847514671 @default.
• W1684751467 hasConcept C104317684 @default.
• W1684751467 hasConcept C150194340 @default.
• W1684751467 hasConcept C161890455 @default.
• W1684751467 hasConcept C169594400 @default.
• W1684751467 hasConcept C190727270 @default.
• W1684751467 hasConcept C3017743773 @default.
• W1684751467 hasConcept C33288867 @default.
• W1684751467 hasConcept C41091548 @default.

• next