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• W1685204680 endingPage "8257" @default.
• W1685204680 startingPage "8247" @default.
• W1685204680 abstract "The insulin family of proteins include insulin-like growth factor binding proteins (IGFBPs) that are classified into two groups based on their differential affinities to IGFs: IGF high-affinity binding proteins (IGFBP1-6) and IGF low-affinity IGFBP-related proteins (IGFBP-rP1-10). IGFBPs interact with many proteins, including their canonical ligands insulin-like growth factor 1 (IGF-I) and IGF-II. Together with insulin-like growth factor 1 (IGF1) receptor (IGF1R), IGF2R, and ligands (IGF1 and IGF2), IGFBPs participate in a complex signaling axis called IGF-IGFR-IGFBP. Numerous studies have demonstrated that the IGF-IGFR-IGFBP axis is relevant in gastrointestinal (GI) and other cancers. The presence of different IGFBPs have been reported in gastrointestinal cancers, including esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAD or EAC), and gastric adenocarcinoma (GAD or GAC). A literature-based survey clearly indicates that an urgent need exists for a focused review of the role of IGFBPs in gastrointestinal cancers. The aim of this review is to present the biochemical and molecular characteristics of IGFBPs with an emphasis specifically on the role of these proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers." @default.
• W1685204680 created "2016-06-24" @default.
• W1685204680 creator A5067776068 @default.
• W1685204680 date "2015-09-14" @default.
• W1685204680 modified "2023-09-23" @default.
• W1685204680 title "Role of insulin-like growth factor-binding proteins in the pathophysiology and tumorigenesis of gastroesophageal cancers" @default.
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• W1685204680 doi "https://doi.org/10.1007/s13277-015-3972-3" @default.
• W1685204680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26369544" @default.
• W1685204680 hasPublicationYear "2015" @default.
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