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- W168521517 abstract "Lymphocytic choriomeningitis virus (LCMV) infection of the mouse presents biologists with a superb experimental model for host-virus interaction. By manipulating the age at infection and the genetic background of mice as well as the strain of infecting virus, one can reproducibly elicit diseases ranging from life long persistent infection to rapidly lethal acute choriomeningitis. In addition to being an important experimental model, LCMV is the prototype virus of the arenavirus group. LCMV and the serologically related African arenaviruses Lassa, Mozambique, and a newly described arenavirus of the Central African Republic form a group informally known as the “Old World”arenaviruses. One of these agents, Lassa virus, is the cause of a severe and often fatal acute disease in man for which there is neither adequate means of prevention nor treatment. This chapter discusses the studies of the immunobiology and biochemistry of LCMV toward two goals: (1) the development of molecular probes and immunologic reagents specific for LCMV to use in the detailed studies of viral pathogenesis and (2) a detailed antigenic study of LCMV and comparison with the pathogenic arenaviruses to develop rational strategies for immunization against these agents." @default.
- W168521517 created "2016-06-24" @default.
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- W168521517 date "1984-01-01" @default.
- W168521517 modified "2023-09-23" @default.
- W168521517 title "ANTIGENIC AND STRUCTURAL STUDIES ON THE GLYCOPROTEINS OF LYMPHOCYTIC CHORIOMENINGITIS VIRUS" @default.
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- W168521517 doi "https://doi.org/10.1016/b978-0-12-183501-9.50032-7" @default.
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