FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W168577092> ?p ?o ?g. }

• W168577092 endingPage "827" @default.
• W168577092 startingPage "827" @default.
• W168577092 abstract "Anabolic activity, phenotypic alterations, and in particular survival of the chondrocytes are essential for the maintenance of proper articular cartilage and appears to fail during osteoarthritic cartilage degeneration. In this study, we investigated the presence and expression of RhoB in adult human articular cartilage and its regulation in osteoarthritic cartilage as well as in chondrocytes in vitro. RhoB belongs to the family of small GTPases, which are thought to be involved in a large range of activities important for eukaryotic cells. Conventional and quantificative PCR analysis showed significant levels of RhoB expression in normal articular cartilage. Immunolocalization and confocal laser scanning microscopy showed strong cytoplasmic signals for RhoB in normal chondrocytes. In osteoarthritic cartilage, a significantly lower expression of RhoB was detectable. In vitro experiments showed a quick (and transient) up-regulation of RhoB after stimulation with interleukin-1beta and serum. Our study suggests that RhoB is constitutively expressed and essential for adult articular chondrocytes, but significantly down-regulated in osteoarthritic chondrocytes. One intriguing speculation might be that the down-regulation of RhoB in osteoarthritic chondrocytes is at least partly a prerequisite for the sustained pre- or para-apoptotic phenotype of osteoarthritic chondrocytes, because RhoB is known to be one important molecule in the induction of apoptotic cell death in response to DNA damage and osteoarthritic chondrocytes are known to have significant DNA damage. Alternatively, RhoB could be involved in the activation or deactivation and the destabilization of the functional phenotype of chondrocytes in osteoarthritic joint degeneration Thirdly, RhoB is associated with the cell cycle, which is re-initiated in osteoarthritis." @default.
• W168577092 created "2016-06-24" @default.
• W168577092 creator A5013387558 @default.
• W168577092 creator A5025457178 @default.
• W168577092 creator A5032053408 @default.
• W168577092 creator A5088207917 @default.
• W168577092 date "2004-01-01" @default.
• W168577092 modified "2023-09-26" @default.
• W168577092 title "Down-regulation of the GTPase RhoB might be involved in the pre-apoptotic phenotype of osteoarthritic chondrocytes" @default.
• W168577092 cites W134770799 @default.
• W168577092 cites W1508097413 @default.
• W168577092 cites W1551310212 @default.
• W168577092 cites W1689052810 @default.
• W168577092 cites W1909400967 @default.
• W168577092 cites W1974653642 @default.
• W168577092 cites W1985490515 @default.
• W168577092 cites W1990513491 @default.
• W168577092 cites W1990844960 @default.
• W168577092 cites W1994901157 @default.
• W168577092 cites W2005328425 @default.
• W168577092 cites W2008370561 @default.
• W168577092 cites W2019731805 @default.
• W168577092 cites W2026748045 @default.
• W168577092 cites W2035466080 @default.
• W168577092 cites W2036098578 @default.
• W168577092 cites W2050486464 @default.
• W168577092 cites W2062522737 @default.
• W168577092 cites W2076053303 @default.
• W168577092 cites W2086624112 @default.
• W168577092 cites W2089938422 @default.
• W168577092 cites W2090891207 @default.
• W168577092 cites W2091235474 @default.
• W168577092 cites W2092550529 @default.
• W168577092 cites W2095168835 @default.
• W168577092 cites W2096791952 @default.
• W168577092 cites W2101496796 @default.
• W168577092 cites W2110981114 @default.
• W168577092 cites W2111416969 @default.
• W168577092 cites W2133837411 @default.
• W168577092 cites W2159315880 @default.
• W168577092 cites W2192757572 @default.
• W168577092 cites W2232879680 @default.
• W168577092 cites W2287764834 @default.
• W168577092 cites W4996342 @default.
• W168577092 doi "https://doi.org/10.2741/1254" @default.
• W168577092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14766412" @default.
• W168577092 hasPublicationYear "2004" @default.
• W168577092 type Work @default.
• W168577092 sameAs 168577092 @default.
• W168577092 citedByCount "14" @default.
• W168577092 countsByYear W1685770922013 @default.
• W168577092 countsByYear W1685770922015 @default.
• W168577092 countsByYear W1685770922016 @default.
• W168577092 countsByYear W1685770922022 @default.
• W168577092 crossrefType "journal-article" @default.
• W168577092 hasAuthorship W168577092A5013387558 @default.
• W168577092 hasAuthorship W168577092A5025457178 @default.
• W168577092 hasAuthorship W168577092A5032053408 @default.
• W168577092 hasAuthorship W168577092A5088207917 @default.
• W168577092 hasBestOaLocation W1685770921 @default.
• W168577092 hasConcept C104317684 @default.
• W168577092 hasConcept C105702510 @default.
• W168577092 hasConcept C127716648 @default.
• W168577092 hasConcept C185592680 @default.
• W168577092 hasConcept C203014093 @default.
• W168577092 hasConcept C2777093181 @default.
• W168577092 hasConcept C2778917187 @default.
• W168577092 hasConcept C2780550940 @default.
• W168577092 hasConcept C2781403057 @default.
• W168577092 hasConcept C502942594 @default.
• W168577092 hasConcept C55493867 @default.
• W168577092 hasConcept C62478195 @default.
• W168577092 hasConcept C86803240 @default.
• W168577092 hasConcept C95444343 @default.
• W168577092 hasConceptScore W168577092C104317684 @default.
• W168577092 hasConceptScore W168577092C105702510 @default.
• W168577092 hasConceptScore W168577092C127716648 @default.
• W168577092 hasConceptScore W168577092C185592680 @default.
• W168577092 hasConceptScore W168577092C203014093 @default.
• W168577092 hasConceptScore W168577092C2777093181 @default.
• W168577092 hasConceptScore W168577092C2778917187 @default.
• W168577092 hasConceptScore W168577092C2780550940 @default.
• W168577092 hasConceptScore W168577092C2781403057 @default.
• W168577092 hasConceptScore W168577092C502942594 @default.
• W168577092 hasConceptScore W168577092C55493867 @default.
• W168577092 hasConceptScore W168577092C62478195 @default.
• W168577092 hasConceptScore W168577092C86803240 @default.
• W168577092 hasConceptScore W168577092C95444343 @default.
• W168577092 hasIssue "1-3" @default.
• W168577092 hasLocation W1685770921 @default.
• W168577092 hasLocation W1685770922 @default.
• W168577092 hasOpenAccess W168577092 @default.
• W168577092 hasPrimaryLocation W1685770921 @default.
• W168577092 hasRelatedWork W1887015675 @default.
• W168577092 hasRelatedWork W1909322285 @default.
• W168577092 hasRelatedWork W2041745288 @default.
• W168577092 hasRelatedWork W2122953542 @default.
• W168577092 hasRelatedWork W2322775524 @default.

• next