FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1686133764> ?p ?o ?g. }

• W1686133764 endingPage "2168" @default.
• W1686133764 startingPage "2155" @default.
• W1686133764 abstract "In this study we further characterized the 3′-5′ exonuclease activity intrinsic to wild-type p53. We showed that this activity, like sequence-specific DNA binding, is mediated by the p53 core domain. Truncation of the C-terminal 30 amino acids of the p53 molecule enhanced the p53 exonuclease activity by at least 10-fold, indicating that this activity, like sequence-specific DNA binding, is negatively regulated by the C-terminal basic regulatory domain of p53. However, treatments which activated sequence-specific DNA binding of p53, like binding of the monoclonal antibody PAb421, which recognizes a C-terminal epitope on p53, or a higher phosphorylation status, strongly inhibited the p53 exonuclease activity. This suggests that at least on full-length p53, sequence-specific DNA binding and exonuclease activities are subject to different and seemingly opposing regulatory mechanisms. Following up the recent discovery in our laboratory that p53 recognizes and binds with high affinity to three-stranded DNA substrates mimicking early recombination intermediates (C. Dudenhoeffer, G. Rohaly, K. Will, W. Deppert, and L. Wiesmueller, Mol. Cell. Biol. 18:5332–5342), we asked whether such substrates might be degraded by the p53 exonuclease. Addition of Mg2+ ions to the binding assay indeed started the p53 exonuclease and promoted rapid degradation of the bound, but not of the unbound, substrate, indicating that specifically recognized targets can be subjected to exonucleolytic degradation by p53 under defined conditions." @default.
• W1686133764 created "2016-06-24" @default.
• W1686133764 creator A5007459786 @default.
• W1686133764 creator A5055240287 @default.
• W1686133764 creator A5055873393 @default.
• W1686133764 creator A5075437310 @default.
• W1686133764 creator A5088847455 @default.
• W1686133764 creator A5091514112 @default.
• W1686133764 date "1999-03-01" @default.
• W1686133764 modified "2023-10-03" @default.
• W1686133764 title "Different Regulation of the p53 Core Domain Activities 3′-to-5′ Exonuclease and Sequence-Specific DNA Binding" @default.
• W1686133764 cites W1518376386 @default.
• W1686133764 cites W1545495395 @default.
• W1686133764 cites W1565881767 @default.
• W1686133764 cites W1591281137 @default.
• W1686133764 cites W168561149 @default.
• W1686133764 cites W1715231693 @default.
• W1686133764 cites W1918570764 @default.
• W1686133764 cites W1970393845 @default.
• W1686133764 cites W1974069821 @default.
• W1686133764 cites W1980655006 @default.
• W1686133764 cites W1983386156 @default.
• W1686133764 cites W1985074745 @default.
• W1686133764 cites W1986179131 @default.
• W1686133764 cites W1993831923 @default.
• W1686133764 cites W1994552302 @default.
• W1686133764 cites W2003236156 @default.
• W1686133764 cites W2005546492 @default.
• W1686133764 cites W2008301561 @default.
• W1686133764 cites W2009115701 @default.
• W1686133764 cites W2012053348 @default.
• W1686133764 cites W2015006770 @default.
• W1686133764 cites W2015314126 @default.
• W1686133764 cites W2015519364 @default.
• W1686133764 cites W2019570564 @default.
• W1686133764 cites W2030283142 @default.
• W1686133764 cites W2043322530 @default.
• W1686133764 cites W2049027902 @default.
• W1686133764 cites W2051182140 @default.
• W1686133764 cites W2063852118 @default.
• W1686133764 cites W2064795157 @default.
• W1686133764 cites W2081115041 @default.
• W1686133764 cites W2081446097 @default.
• W1686133764 cites W2089218510 @default.
• W1686133764 cites W2095899775 @default.
• W1686133764 cites W2096079439 @default.
• W1686133764 cites W2096276671 @default.
• W1686133764 cites W2105974945 @default.
• W1686133764 cites W2113314034 @default.
• W1686133764 cites W2128583894 @default.
• W1686133764 cites W2134871100 @default.
• W1686133764 cites W2141980923 @default.
• W1686133764 cites W2143529834 @default.
• W1686133764 cites W2158333896 @default.
• W1686133764 cites W2164436574 @default.
• W1686133764 cites W2170494099 @default.
• W1686133764 cites W2171458163 @default.
• W1686133764 cites W2239325055 @default.
• W1686133764 cites W2260706862 @default.
• W1686133764 cites W2403580586 @default.
• W1686133764 cites W54722803 @default.
• W1686133764 doi "https://doi.org/10.1128/mcb.19.3.2155" @default.
• W1686133764 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/84008" @default.
• W1686133764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10022902" @default.
• W1686133764 hasPublicationYear "1999" @default.
• W1686133764 type Work @default.
• W1686133764 sameAs 1686133764 @default.
• W1686133764 citedByCount "50" @default.
• W1686133764 countsByYear W16861337642012 @default.
• W1686133764 countsByYear W16861337642013 @default.
• W1686133764 countsByYear W16861337642014 @default.
• W1686133764 countsByYear W16861337642018 @default.
• W1686133764 countsByYear W16861337642020 @default.
• W1686133764 countsByYear W16861337642021 @default.
• W1686133764 countsByYear W16861337642022 @default.
• W1686133764 crossrefType "journal-article" @default.
• W1686133764 hasAuthorship W1686133764A5007459786 @default.
• W1686133764 hasAuthorship W1686133764A5055240287 @default.
• W1686133764 hasAuthorship W1686133764A5055873393 @default.
• W1686133764 hasAuthorship W1686133764A5075437310 @default.
• W1686133764 hasAuthorship W1686133764A5088847455 @default.
• W1686133764 hasAuthorship W1686133764A5091514112 @default.
• W1686133764 hasBestOaLocation W16861337642 @default.
• W1686133764 hasConcept C107824862 @default.
• W1686133764 hasConcept C134935766 @default.
• W1686133764 hasConcept C153911025 @default.
• W1686133764 hasConcept C174742784 @default.
• W1686133764 hasConcept C2756471 @default.
• W1686133764 hasConcept C2777501222 @default.
• W1686133764 hasConcept C552990157 @default.
• W1686133764 hasConcept C55493867 @default.
• W1686133764 hasConcept C86803240 @default.
• W1686133764 hasConcept C95444343 @default.
• W1686133764 hasConceptScore W1686133764C107824862 @default.
• W1686133764 hasConceptScore W1686133764C134935766 @default.
• W1686133764 hasConceptScore W1686133764C153911025 @default.
• W1686133764 hasConceptScore W1686133764C174742784 @default.
• W1686133764 hasConceptScore W1686133764C2756471 @default.

• next