FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1686409300> ?p ?o ?g. }

• W1686409300 abstract "Background— We investigated whether differentiation of embryonic stem cells (ESCs) in ischemic myocardium enhances their immunogenicity, thereby increasing their chance for rejection. Methods and Results— In one series, 129/SvJ-derived mouse ESCs (ES-D3 line) were transplanted by direct myocardial injection (1×10 6 cells) into murine hearts of both allogeneic (BALB/c, n=20) and syngeneic (129/SvJ, n=12) recipients after left anterior artery ligation. Hearts were procured at 1, 2, 4, and 8 weeks after ESC transplantation and analyzed by immunohistochemistry to assess immune cell infiltration (CD3, CD4, CD8, B220, CD11c, Mac-1, and Gr-1) and ESC differentiation (hematoxylin and eosin). In a second series (allogeneic n=5, sham n=3), ESC transplantation was performed similarly; however after 2 weeks, left anterior descending artery-ligated and ESC-injected hearts were heterotopically transplanted into naive BALB/c recipients. After an additional 2 weeks, donor hearts were procured and analyzed by immunohistochemistry. In the first series, the size of all ESC grafts remained stable and there was no evidence of ESC differentiation 2 weeks after transplantation; however, after 4 weeks, both allogeneic and syngeneic ESC grafts showed the presence of teratoma. By 8 weeks, surviving ESCs could be detected in the syngeneic but not in the allogeneic group. Mild inflammatory cellular infiltrates were found in allogeneic recipients at 1 and 2 weeks after transplantation, progressing into vigorous infiltration at 4 and 8 weeks. The second series demonstrated similar vigorous infiltration of immune cells as early as 2 weeks after heterotopic transplantation. Conclusion— In vivo differentiated ESCs elicit an accelerated immune response as compared with undifferentiated ESCs. These data imply that clinical transplantation of allogeneic ESCs or ESC derivatives for treatment of cardiac failure might require immunosuppressive therapy." @default.
• W1686409300 created "2016-06-24" @default.
• W1686409300 creator A5002197635 @default.
• W1686409300 creator A5012009901 @default.
• W1686409300 creator A5016659217 @default.
• W1686409300 creator A5017135192 @default.
• W1686409300 creator A5020516257 @default.
• W1686409300 creator A5022156712 @default.
• W1686409300 creator A5034713742 @default.
• W1686409300 creator A5041334417 @default.
• W1686409300 creator A5054247350 @default.
• W1686409300 creator A5055929035 @default.
• W1686409300 creator A5074245010 @default.
• W1686409300 date "2005-08-30" @default.
• W1686409300 modified "2023-10-16" @default.
• W1686409300 title "Embryonic Stem Cell Immunogenicity Increases Upon Differentiation After Transplantation Into Ischemic Myocardium" @default.
• W1686409300 cites W1631250427 @default.
• W1686409300 cites W1972662556 @default.
• W1686409300 cites W1979608640 @default.
• W1686409300 cites W1997480031 @default.
• W1686409300 cites W2010847353 @default.
• W1686409300 cites W2018570885 @default.
• W1686409300 cites W2025950643 @default.
• W1686409300 cites W2034293734 @default.
• W1686409300 cites W2048465868 @default.
• W1686409300 cites W2067846827 @default.
• W1686409300 cites W2068380542 @default.
• W1686409300 cites W2080070415 @default.
• W1686409300 cites W2086943348 @default.
• W1686409300 cites W2088088839 @default.
• W1686409300 cites W2088494611 @default.
• W1686409300 cites W2090041902 @default.
• W1686409300 cites W2099583913 @default.
• W1686409300 cites W2131429452 @default.
• W1686409300 cites W2136071912 @default.
• W1686409300 cites W2151517892 @default.
• W1686409300 cites W4246928383 @default.
• W1686409300 doi "https://doi.org/10.1161/circulationaha.104.525824" @default.
• W1686409300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16159810" @default.
• W1686409300 hasPublicationYear "2005" @default.
• W1686409300 type Work @default.
• W1686409300 sameAs 1686409300 @default.
• W1686409300 citedByCount "250" @default.
• W1686409300 countsByYear W16864093002012 @default.
• W1686409300 countsByYear W16864093002013 @default.
• W1686409300 countsByYear W16864093002014 @default.
• W1686409300 countsByYear W16864093002015 @default.
• W1686409300 countsByYear W16864093002016 @default.
• W1686409300 countsByYear W16864093002017 @default.
• W1686409300 countsByYear W16864093002018 @default.
• W1686409300 countsByYear W16864093002019 @default.
• W1686409300 countsByYear W16864093002020 @default.
• W1686409300 countsByYear W16864093002021 @default.
• W1686409300 countsByYear W16864093002022 @default.
• W1686409300 countsByYear W16864093002023 @default.
• W1686409300 crossrefType "journal-article" @default.
• W1686409300 hasAuthorship W1686409300A5002197635 @default.
• W1686409300 hasAuthorship W1686409300A5012009901 @default.
• W1686409300 hasAuthorship W1686409300A5016659217 @default.
• W1686409300 hasAuthorship W1686409300A5017135192 @default.
• W1686409300 hasAuthorship W1686409300A5020516257 @default.
• W1686409300 hasAuthorship W1686409300A5022156712 @default.
• W1686409300 hasAuthorship W1686409300A5034713742 @default.
• W1686409300 hasAuthorship W1686409300A5041334417 @default.
• W1686409300 hasAuthorship W1686409300A5054247350 @default.
• W1686409300 hasAuthorship W1686409300A5055929035 @default.
• W1686409300 hasAuthorship W1686409300A5074245010 @default.
• W1686409300 hasBestOaLocation W16864093001 @default.
• W1686409300 hasConcept C125473707 @default.
• W1686409300 hasConcept C126322002 @default.
• W1686409300 hasConcept C142724271 @default.
• W1686409300 hasConcept C16685009 @default.
• W1686409300 hasConcept C167672396 @default.
• W1686409300 hasConcept C203014093 @default.
• W1686409300 hasConcept C204232928 @default.
• W1686409300 hasConcept C2780868878 @default.
• W1686409300 hasConcept C28328180 @default.
• W1686409300 hasConcept C2911091166 @default.
• W1686409300 hasConcept C71924100 @default.
• W1686409300 hasConcept C86803240 @default.
• W1686409300 hasConcept C8891405 @default.
• W1686409300 hasConcept C95444343 @default.
• W1686409300 hasConceptScore W1686409300C125473707 @default.
• W1686409300 hasConceptScore W1686409300C126322002 @default.
• W1686409300 hasConceptScore W1686409300C142724271 @default.
• W1686409300 hasConceptScore W1686409300C16685009 @default.
• W1686409300 hasConceptScore W1686409300C167672396 @default.
• W1686409300 hasConceptScore W1686409300C203014093 @default.
• W1686409300 hasConceptScore W1686409300C204232928 @default.
• W1686409300 hasConceptScore W1686409300C2780868878 @default.
• W1686409300 hasConceptScore W1686409300C28328180 @default.
• W1686409300 hasConceptScore W1686409300C2911091166 @default.
• W1686409300 hasConceptScore W1686409300C71924100 @default.
• W1686409300 hasConceptScore W1686409300C86803240 @default.
• W1686409300 hasConceptScore W1686409300C8891405 @default.
• W1686409300 hasConceptScore W1686409300C95444343 @default.
• W1686409300 hasIssue "9_supplement" @default.
• W1686409300 hasLocation W16864093001 @default.
• W1686409300 hasLocation W16864093002 @default.
• W1686409300 hasOpenAccess W1686409300 @default.

• next