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- W168880773 abstract "G protein-coupled receptors (GPCRs) constitute one of the largest superfamilies of proteins in the human genome. It is estimated that there are at least 600 and probably over 1000 receptor species. The known ones are the target for approximately 60% of today’s medicines for such diverse disease states as high blood pressure (β-adrenoceptor and angiotensin receptor antagonists), asthma (β-adrenoceptor agonists), and acid overproduction in the stomach (histamine H2 receptor antagonists). Each member shares structural and/or sequence motifs and operates by common transduction mechanisms to mediate the transmission of extracellular signals into biochemical or electrophysiological responses within a cell. The signalling species is a specific endogenous molecule (e.g., neurotransmitter or hormone) which binds to the receptor. This results in activation of receptor and intracellularly located G proteins and propagation of the signal to effector molecules such as adenylyl cyclase. This enzyme converts ATP into cyclic AMP, the classical “second” messenger." @default.
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- W168880773 date "2003-01-01" @default.
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- W168880773 title "Enantioselectivity in Drug-Receptor Interactions" @default.
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