FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1688971704> ?p ?o ?g. }

• W1688971704 endingPage "2967" @default.
• W1688971704 startingPage "2958" @default.
• W1688971704 abstract "Fat metaplasia in bone marrow on T1-weighted magnetic resonance imaging (MRI) scans may develop after resolution of inflammation in patients with ankylosing spondylitis (AS) and may predict new bone formation in the spine. Similar tissue, termed backfill, may also fill areas of excavated bone in the sacroiliac (SI) joints and may reflect resolution of inflammation and tissue repair at sites of erosions. The purpose of this study was to test our hypothesis that SI joint ankylosis develops following repair of erosions and that tissue characterized by fat metaplasia is a key intermediary step in this pathway.We used the Spondyloarthritis Research Consortium of Canada (SPARCC) SI structural lesion score (SSS) method to assess fat metaplasia, erosions, backfill, and ankylosis on MRIs of the SI joints in 147 patients with AS monitored for 2 years. Univariate and multivariate regression analyses focused first on identifying significant MRI predictors of new backfill and fat metaplasia. We then assessed the role of backfill and fat metaplasia in the development of new ankylosis. All analyses were adjusted for demographic features, treatment, and baseline and 2-year change in SSS values for parameters of inflammation and MRI structural lesions.Resolution of inflammation and reduction of erosions were each independently associated with the development of new backfill and fat metaplasia at 2 years on multivariate analyses. Multivariate regression analysis that included demographic features, baseline and 2-year change in parameters of inflammation and MRI structural lesion showed that reduction in erosions (P = 0.0005) and increase in fat metaplasia (P = 0.002) at 2 years was each independently associated with the development of new ankylosis.Our data support a disease model whereby ankylosis develops following repair of erosions, and fat metaplasia and backfill are key intermediary steps in this pathway." @default.
• W1688971704 created "2016-06-24" @default.
• W1688971704 creator A5019054146 @default.
• W1688971704 creator A5028102614 @default.
• W1688971704 creator A5036434857 @default.
• W1688971704 creator A5069979151 @default.
• W1688971704 creator A5073062098 @default.
• W1688971704 date "2014-10-26" @default.
• W1688971704 modified "2023-10-12" @default.
• W1688971704 title "Fat Metaplasia and Backfill Are Key Intermediaries in the Development of Sacroiliac Joint Ankylosis in Patients With Ankylosing Spondylitis" @default.
• W1688971704 cites W1497700962 @default.
• W1688971704 cites W1966756689 @default.
• W1688971704 cites W1971077979 @default.
• W1688971704 cites W1981118183 @default.
• W1688971704 cites W1983746078 @default.
• W1688971704 cites W1995695847 @default.
• W1688971704 cites W1996740437 @default.
• W1688971704 cites W2027423876 @default.
• W1688971704 cites W2029100651 @default.
• W1688971704 cites W2033331027 @default.
• W1688971704 cites W2043981736 @default.
• W1688971704 cites W2048805333 @default.
• W1688971704 cites W2070855360 @default.
• W1688971704 cites W2078597296 @default.
• W1688971704 cites W2082649626 @default.
• W1688971704 cites W2093928471 @default.
• W1688971704 cites W2096827857 @default.
• W1688971704 cites W2102138771 @default.
• W1688971704 cites W2104749385 @default.
• W1688971704 cites W2104916764 @default.
• W1688971704 cites W2105285849 @default.
• W1688971704 cites W2109531704 @default.
• W1688971704 cites W2110143456 @default.
• W1688971704 cites W2113203684 @default.
• W1688971704 cites W2120699390 @default.
• W1688971704 cites W2123235923 @default.
• W1688971704 cites W2125389221 @default.
• W1688971704 cites W2135336890 @default.
• W1688971704 cites W2154748957 @default.
• W1688971704 cites W2336091041 @default.
• W1688971704 doi "https://doi.org/10.1002/art.38792" @default.
• W1688971704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25047851" @default.
• W1688971704 hasPublicationYear "2014" @default.
• W1688971704 type Work @default.
• W1688971704 sameAs 1688971704 @default.
• W1688971704 citedByCount "109" @default.
• W1688971704 countsByYear W16889717042014 @default.
• W1688971704 countsByYear W16889717042015 @default.
• W1688971704 countsByYear W16889717042016 @default.
• W1688971704 countsByYear W16889717042017 @default.
• W1688971704 countsByYear W16889717042018 @default.
• W1688971704 countsByYear W16889717042019 @default.
• W1688971704 countsByYear W16889717042020 @default.
• W1688971704 countsByYear W16889717042021 @default.
• W1688971704 countsByYear W16889717042022 @default.
• W1688971704 countsByYear W16889717042023 @default.
• W1688971704 crossrefType "journal-article" @default.
• W1688971704 hasAuthorship W1688971704A5019054146 @default.
• W1688971704 hasAuthorship W1688971704A5028102614 @default.
• W1688971704 hasAuthorship W1688971704A5036434857 @default.
• W1688971704 hasAuthorship W1688971704A5069979151 @default.
• W1688971704 hasAuthorship W1688971704A5073062098 @default.
• W1688971704 hasBestOaLocation W16889717041 @default.
• W1688971704 hasConcept C126322002 @default.
• W1688971704 hasConcept C126838900 @default.
• W1688971704 hasConcept C141071460 @default.
• W1688971704 hasConcept C142724271 @default.
• W1688971704 hasConcept C143409427 @default.
• W1688971704 hasConcept C2776914184 @default.
• W1688971704 hasConcept C2777366695 @default.
• W1688971704 hasConcept C2777402515 @default.
• W1688971704 hasConcept C2779357193 @default.
• W1688971704 hasConcept C71924100 @default.
• W1688971704 hasConceptScore W1688971704C126322002 @default.
• W1688971704 hasConceptScore W1688971704C126838900 @default.
• W1688971704 hasConceptScore W1688971704C141071460 @default.
• W1688971704 hasConceptScore W1688971704C142724271 @default.
• W1688971704 hasConceptScore W1688971704C143409427 @default.
• W1688971704 hasConceptScore W1688971704C2776914184 @default.
• W1688971704 hasConceptScore W1688971704C2777366695 @default.
• W1688971704 hasConceptScore W1688971704C2777402515 @default.
• W1688971704 hasConceptScore W1688971704C2779357193 @default.
• W1688971704 hasConceptScore W1688971704C71924100 @default.
• W1688971704 hasFunder F4320319927 @default.
• W1688971704 hasIssue "11" @default.
• W1688971704 hasLocation W16889717041 @default.
• W1688971704 hasLocation W16889717042 @default.
• W1688971704 hasOpenAccess W1688971704 @default.
• W1688971704 hasPrimaryLocation W16889717041 @default.
• W1688971704 hasRelatedWork W124623371 @default.
• W1688971704 hasRelatedWork W1688971704 @default.
• W1688971704 hasRelatedWork W2406761864 @default.
• W1688971704 hasRelatedWork W2469418095 @default.
• W1688971704 hasRelatedWork W2522299904 @default.
• W1688971704 hasRelatedWork W2530056102 @default.
• W1688971704 hasRelatedWork W2599618767 @default.
• W1688971704 hasRelatedWork W4220866626 @default.
• W1688971704 hasRelatedWork W4224240955 @default.

• next