FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1689103485> ?p ?o ?g. }

• W1689103485 endingPage "132" @default.
• W1689103485 startingPage "123" @default.
• W1689103485 abstract "Approximately 13 million people worldwide have been infected with human immunodeficiency virus (HIV). The delineation of the lifecycle of HIV has shown that the virus requires the catalytic activity of many unique enzymes, thereby providing attractive targets for therapeutic intervention. Researchers have most actively targeted the inhibition of the enzymes reverse transcriptase (RT) and protease. RT is a heterodimeric enzyme comprised of two polypeptides of 51-kDa and 66-kDa. These peptides have an identical N-terminus and the smaller p51 peptide is derived, from the larger p66 peptide, via proteolytic cleavage. The multi-purpose enzyme has three distinct catalytic functions, such as, an RNA-dependent DNA polymerase activity, an RNAse H activity that degrades the RNA template to make way for the final function, a DNA-dependent DNA polymerase activity. HIV infection is a chronic process that involves high rates of viral replication and employs the highly error prone enzyme HIV R. Three-dimensional structural studies of HIV-1 RT have provided an enhanced understanding of the structure–function relationships and aid in future drug design. Resistance to azidothymidine (AZT) contributes to the loss of efficacy of AZT during the timecourse of treatment and such AZT resistant HIV-1 is virulent enough to contribute to the disease progression. The differential anti-viral activity of the enantiorners of FTC happens, because of the differences in cellular metabolism, not inherent differences in the RT inhibitory activity." @default.
• W1689103485 created "2016-06-24" @default.
• W1689103485 creator A5089012257 @default.
• W1689103485 date "1994-01-01" @default.
• W1689103485 modified "2023-10-14" @default.
• W1689103485 title "Chapter 13. Advances in the Development of HIV Reverse Transcriptase Inhibitors" @default.
• W1689103485 cites W1515636527 @default.
• W1689103485 cites W1970106134 @default.
• W1689103485 cites W1970850106 @default.
• W1689103485 cites W1975170174 @default.
• W1689103485 cites W1988847244 @default.
• W1689103485 cites W1993061861 @default.
• W1689103485 cites W1995482789 @default.
• W1689103485 cites W2002403041 @default.
• W1689103485 cites W2003903604 @default.
• W1689103485 cites W2006559816 @default.
• W1689103485 cites W2008954911 @default.
• W1689103485 cites W2009346838 @default.
• W1689103485 cites W2010944339 @default.
• W1689103485 cites W2015696347 @default.
• W1689103485 cites W2028143521 @default.
• W1689103485 cites W2030750689 @default.
• W1689103485 cites W2031269308 @default.
• W1689103485 cites W2038311079 @default.
• W1689103485 cites W2044864734 @default.
• W1689103485 cites W2044976783 @default.
• W1689103485 cites W2046134251 @default.
• W1689103485 cites W2047741951 @default.
• W1689103485 cites W2048134214 @default.
• W1689103485 cites W2055705838 @default.
• W1689103485 cites W2058737372 @default.
• W1689103485 cites W2061566909 @default.
• W1689103485 cites W2062261252 @default.
• W1689103485 cites W2063176659 @default.
• W1689103485 cites W2065577535 @default.
• W1689103485 cites W2065740427 @default.
• W1689103485 cites W2068705423 @default.
• W1689103485 cites W2071313281 @default.
• W1689103485 cites W2072409481 @default.
• W1689103485 cites W2074495023 @default.
• W1689103485 cites W2079242080 @default.
• W1689103485 cites W2079935130 @default.
• W1689103485 cites W2085524035 @default.
• W1689103485 cites W2086462809 @default.
• W1689103485 cites W2087331278 @default.
• W1689103485 cites W2090126383 @default.
• W1689103485 cites W2090765620 @default.
• W1689103485 cites W2092492915 @default.
• W1689103485 cites W2095725835 @default.
• W1689103485 cites W2115853658 @default.
• W1689103485 cites W2116712233 @default.
• W1689103485 cites W2124217674 @default.
• W1689103485 cites W2129048881 @default.
• W1689103485 cites W2137956846 @default.
• W1689103485 cites W2139942039 @default.
• W1689103485 cites W2143663670 @default.
• W1689103485 cites W2156502258 @default.
• W1689103485 cites W2318103134 @default.
• W1689103485 cites W2337143807 @default.
• W1689103485 cites W2343658917 @default.
• W1689103485 cites W2464988942 @default.
• W1689103485 cites W2949465188 @default.
• W1689103485 cites W4251546761 @default.
• W1689103485 cites W4256221661 @default.
• W1689103485 doi "https://doi.org/10.1016/s0065-7743(08)60726-5" @default.
• W1689103485 hasPublicationYear "1994" @default.
• W1689103485 type Work @default.
• W1689103485 sameAs 1689103485 @default.
• W1689103485 citedByCount "24" @default.
• W1689103485 countsByYear W16891034852013 @default.
• W1689103485 countsByYear W16891034852014 @default.
• W1689103485 countsByYear W16891034852015 @default.
• W1689103485 countsByYear W16891034852016 @default.
• W1689103485 countsByYear W16891034852017 @default.
• W1689103485 countsByYear W16891034852018 @default.
• W1689103485 countsByYear W16891034852019 @default.
• W1689103485 countsByYear W16891034852022 @default.
• W1689103485 crossrefType "book-chapter" @default.
• W1689103485 hasAuthorship W1689103485A5089012257 @default.
• W1689103485 hasConcept C104317684 @default.
• W1689103485 hasConcept C10879258 @default.
• W1689103485 hasConcept C140704245 @default.
• W1689103485 hasConcept C156719811 @default.
• W1689103485 hasConcept C159047783 @default.
• W1689103485 hasConcept C181199279 @default.
• W1689103485 hasConcept C2522874641 @default.
• W1689103485 hasConcept C2756471 @default.
• W1689103485 hasConcept C2776714187 @default.
• W1689103485 hasConcept C552990157 @default.
• W1689103485 hasConcept C55493867 @default.
• W1689103485 hasConcept C67705224 @default.
• W1689103485 hasConcept C69766542 @default.
• W1689103485 hasConcept C82381507 @default.
• W1689103485 hasConcept C86803240 @default.
• W1689103485 hasConceptScore W1689103485C104317684 @default.
• W1689103485 hasConceptScore W1689103485C10879258 @default.
• W1689103485 hasConceptScore W1689103485C140704245 @default.
• W1689103485 hasConceptScore W1689103485C156719811 @default.

• next