Matches in SemOpenAlex for { <https://semopenalex.org/work/W1689652926> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W1689652926 endingPage "540" @default.
- W1689652926 startingPage "535" @default.
- W1689652926 abstract "Although the factors contributing to the progression of prostate cancer (PC) remain incompletely understood, androgens have long been recognized to play a central role in this process. Upon entering PC cells, androgens bind to a cognate nuclear receptor, the androgen receptor (AR). The activated AR translocates to the nucleus, binds as a dimer to androgen response elements (AREs) in the promoter of target genes, where it recruits the coactivator proteins necessary for the formation of a productive transcriptional complex, an event crucial for PC cell viability. For many decades, the androgen dependency of PCs has been exploited therapeutically by androgen ablation strategies. Although initially successful, these forms of therapy almost inevitably fail eventually, and an androgen depletion independent (ADI) disease emerges, for which currently no cure is available. Studies from our laboratory and others demonstrate that despite low circulating levels of functional androgens, the AR is critical for the proliferation and survival of ADI PC cells. Recent data indicate that alterations in the expression and/or activity of AR coactivator proteins occur during PC progression that can foster ADI activation of the AR. Here, we have investigated the role of the coactivator p300 in AR transcriptional activity and progression of PC." @default.
- W1689652926 created "2016-06-24" @default.
- W1689652926 creator A5014512900 @default.
- W1689652926 creator A5026531632 @default.
- W1689652926 creator A5036744682 @default.
- W1689652926 date "2008-01-01" @default.
- W1689652926 modified "2023-10-14" @default.
- W1689652926 title "The Role of the Transcriptional Coactivator p300 in Prostate Cancer Progression" @default.
- W1689652926 cites W1988049837 @default.
- W1689652926 cites W2024952193 @default.
- W1689652926 cites W2036565444 @default.
- W1689652926 cites W2066086539 @default.
- W1689652926 cites W2071705420 @default.
- W1689652926 cites W2075760937 @default.
- W1689652926 cites W2103177037 @default.
- W1689652926 cites W2107558077 @default.
- W1689652926 cites W2146027649 @default.
- W1689652926 cites W4249786873 @default.
- W1689652926 doi "https://doi.org/10.1007/978-0-387-69080-3_54" @default.
- W1689652926 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2667242" @default.
- W1689652926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18497079" @default.
- W1689652926 hasPublicationYear "2008" @default.
- W1689652926 type Work @default.
- W1689652926 sameAs 1689652926 @default.
- W1689652926 citedByCount "28" @default.
- W1689652926 countsByYear W16896529262012 @default.
- W1689652926 countsByYear W16896529262013 @default.
- W1689652926 countsByYear W16896529262014 @default.
- W1689652926 countsByYear W16896529262015 @default.
- W1689652926 countsByYear W16896529262016 @default.
- W1689652926 countsByYear W16896529262018 @default.
- W1689652926 countsByYear W16896529262019 @default.
- W1689652926 countsByYear W16896529262020 @default.
- W1689652926 countsByYear W16896529262021 @default.
- W1689652926 countsByYear W16896529262022 @default.
- W1689652926 countsByYear W16896529262023 @default.
- W1689652926 crossrefType "book-chapter" @default.
- W1689652926 hasAuthorship W1689652926A5014512900 @default.
- W1689652926 hasAuthorship W1689652926A5026531632 @default.
- W1689652926 hasAuthorship W1689652926A5036744682 @default.
- W1689652926 hasBestOaLocation W16896529262 @default.
- W1689652926 hasConcept C104317684 @default.
- W1689652926 hasConcept C121608353 @default.
- W1689652926 hasConcept C126322002 @default.
- W1689652926 hasConcept C134018914 @default.
- W1689652926 hasConcept C185592680 @default.
- W1689652926 hasConcept C203966977 @default.
- W1689652926 hasConcept C2777911890 @default.
- W1689652926 hasConcept C2780192828 @default.
- W1689652926 hasConcept C502942594 @default.
- W1689652926 hasConcept C54355233 @default.
- W1689652926 hasConcept C61367390 @default.
- W1689652926 hasConcept C63932345 @default.
- W1689652926 hasConcept C71315377 @default.
- W1689652926 hasConcept C71924100 @default.
- W1689652926 hasConcept C77445288 @default.
- W1689652926 hasConcept C86339819 @default.
- W1689652926 hasConcept C86803240 @default.
- W1689652926 hasConcept C95444343 @default.
- W1689652926 hasConceptScore W1689652926C104317684 @default.
- W1689652926 hasConceptScore W1689652926C121608353 @default.
- W1689652926 hasConceptScore W1689652926C126322002 @default.
- W1689652926 hasConceptScore W1689652926C134018914 @default.
- W1689652926 hasConceptScore W1689652926C185592680 @default.
- W1689652926 hasConceptScore W1689652926C203966977 @default.
- W1689652926 hasConceptScore W1689652926C2777911890 @default.
- W1689652926 hasConceptScore W1689652926C2780192828 @default.
- W1689652926 hasConceptScore W1689652926C502942594 @default.
- W1689652926 hasConceptScore W1689652926C54355233 @default.
- W1689652926 hasConceptScore W1689652926C61367390 @default.
- W1689652926 hasConceptScore W1689652926C63932345 @default.
- W1689652926 hasConceptScore W1689652926C71315377 @default.
- W1689652926 hasConceptScore W1689652926C71924100 @default.
- W1689652926 hasConceptScore W1689652926C77445288 @default.
- W1689652926 hasConceptScore W1689652926C86339819 @default.
- W1689652926 hasConceptScore W1689652926C86803240 @default.
- W1689652926 hasConceptScore W1689652926C95444343 @default.
- W1689652926 hasLocation W16896529261 @default.
- W1689652926 hasLocation W16896529262 @default.
- W1689652926 hasLocation W16896529263 @default.
- W1689652926 hasLocation W16896529264 @default.
- W1689652926 hasOpenAccess W1689652926 @default.
- W1689652926 hasPrimaryLocation W16896529261 @default.
- W1689652926 hasRelatedWork W1689652926 @default.
- W1689652926 hasRelatedWork W2001036136 @default.
- W1689652926 hasRelatedWork W2004261902 @default.
- W1689652926 hasRelatedWork W2072661483 @default.
- W1689652926 hasRelatedWork W2103250319 @default.
- W1689652926 hasRelatedWork W2117325725 @default.
- W1689652926 hasRelatedWork W2132550827 @default.
- W1689652926 hasRelatedWork W2165177861 @default.
- W1689652926 hasRelatedWork W2171723716 @default.
- W1689652926 hasRelatedWork W1932077478 @default.
- W1689652926 isParatext "false" @default.
- W1689652926 isRetracted "false" @default.
- W1689652926 magId "1689652926" @default.
- W1689652926 workType "book-chapter" @default.