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- W168977700 abstract "An ethanolic extract was obtained from the funicles of Acacia auriculiformis. The extract was allowed to evaporate and the residue thus obtained was administered orally to 4 pariah dogs naturally infected with Dirofilaria immitis at 150mg/kg/day for 45 days. The treatment resulted in 98% and 99% reduction in microfilarial density on day 45 and day 75, respectively following the onset of treatment. Microfilarial density rose gradually and the level of reduction in the sampling on day 165 was 59%. No toxic effect in the form of a change in movement, body weight and temperature was observed in the treated dogs. The prolonged maintenance of reduced level of microfilarial density may be ascribed to the partial elimination of adult worms. Key Wom2rs: Acacia aunculiformis, Funicles, Ethanolic extract, Dirofilaria immitis Acac由auncul的rmis A. cunn (family-Mimosaceae) locally called `Akashmani'is grown in forests and avenues throughout India. Ghosh βl aι, (1993) showed filaricidal properties of two triterpenoid saponms Acaciaside A and Acaciaside B obtained from the funicles of this plant. The saponins when tested on Setana cervi transplanted in rats were found effective against both microfilana and adult worms. We have already reported filaricidal properties of Andrographis panicuiata and Zingiber officinale (Dutta and Sukul, 1982; Datta and Sukul, 1987). Antifilarial effect of Solamargine, a steroidal alkaloid glycoside isolated from the ripe berries of Solanum khastanum, was reported earlier (Ghosh et al., 1994). In the present study the ethanolic extract of the funicles of A. auriculiformis was tested on dogs naturally infected with Dirofilaria immitis. The ethanolic extract contains saponins. The purpose is to see if the desired objective is achieved wi也out going through the complex and expensive procedure of purification of the active compound. The血nicies of A. aum2eul的珊由were dried in the shed and ground. The powdered material was extracted with 90% ethanol at room temperature (27±3°C). The ethanolic extract obtained after the removal of the solvent under reduced pressure, was dried over anhydrous calcium chloride. The albino rats were selected for the toxicity test. The rats were kept in cages with access to food and water ad libitum. The re由due from the ethanolic extract was mixed with Received for Publication, October 30, 1994" @default.
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- W168977700 date "1995-06-23" @default.
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- W168977700 title "Antifilarial Effect of a Plant Acacia auriculiformis on Canine Dirofilariasis" @default.
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