FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W168986412> ?p ?o ?g. }

• W168986412 endingPage "250" @default.
• W168986412 startingPage "229" @default.
• W168986412 abstract "The human complement system consists of more than thirty proteins, which are either soluble in body fluids, especially the blood plasma, or bound to cell membranes (for a recent overview, see Morley and Walport, 2000). These complement components are organized in three activating pathways and one terminal pathway (Figure 1). Activation of the system occurs via the classical, alternative, or lectin pathway, on recognition of particulate materials by binding of complement proteins to charge or carbohydrate arrays (Sim, 1993). This eventually results in the assembly of unstable protease complexes called the C3 convertases, C4b2a and C3bBb, which activate the central complement component C3. The major fragment of activated C3, C3b, binds covalently to complement-activating surfaces, and is responsible for initiating most of the effector mechanisms of the system. C3b and its cleaved form, iC3b, act as opsonins, enhancing phagocytosis of the complement-activating particles, while C3b can also combine with the C3 convertases to form C5 convertases and initiate the assembly of the membrane attack complex (MAC) which can insert into a lipid bilayer on the target cell, causing cell lysis. The minor fragment of activated C3, C3a, is an anaphylatoxin, and like the other anaphylatoxins of the complement system, C4a and C5a, it can mediate inflammatory responses, including smooth muscle contraction and increased vascular permeability. Therefore, the complement system recognizes and targets potentially harmful molecules or cells for destruction by opsonisation, cell lysis, or induction of the inflammatory response. In addition, other effector mechanisms of the system have been reported, which include solubilization of immune complexes and targeting of antigen to B-cells (Dempsey et al., 1996) and to dendritic cells. Excessive or inappropriate activation of complement may damage host tissue, and the system is under elaborate control by regulatory proteins." @default.
• W168986412 created "2016-06-24" @default.
• W168986412 creator A5065300164 @default.
• W168986412 creator A5083459498 @default.
• W168986412 creator A5090308773 @default.
• W168986412 date "2003-01-01" @default.
• W168986412 modified "2023-10-11" @default.
• W168986412 title "The Mannose-Binding Lectin (MBL) Route for Activation of Complement" @default.
• W168986412 cites W1253835855 @default.
• W168986412 cites W1512118356 @default.
• W168986412 cites W1521864409 @default.
• W168986412 cites W1522572101 @default.
• W168986412 cites W1528847106 @default.
• W168986412 cites W1529358426 @default.
• W168986412 cites W1549249022 @default.
• W168986412 cites W1557110838 @default.
• W168986412 cites W1592289975 @default.
• W168986412 cites W159418275 @default.
• W168986412 cites W1596038018 @default.
• W168986412 cites W1606330082 @default.
• W168986412 cites W1660694569 @default.
• W168986412 cites W1862745872 @default.
• W168986412 cites W1911689173 @default.
• W168986412 cites W1911746360 @default.
• W168986412 cites W1914909226 @default.
• W168986412 cites W1962685102 @default.
• W168986412 cites W1966576522 @default.
• W168986412 cites W1977713879 @default.
• W168986412 cites W1978567121 @default.
• W168986412 cites W1979999043 @default.
• W168986412 cites W1982669893 @default.
• W168986412 cites W1984469505 @default.
• W168986412 cites W1986753899 @default.
• W168986412 cites W1986812790 @default.
• W168986412 cites W1991051424 @default.
• W168986412 cites W1991163875 @default.
• W168986412 cites W1992830524 @default.
• W168986412 cites W1995507202 @default.
• W168986412 cites W1998005981 @default.
• W168986412 cites W1999570749 @default.
• W168986412 cites W2003547090 @default.
• W168986412 cites W2005680431 @default.
• W168986412 cites W2006663423 @default.
• W168986412 cites W2013993952 @default.
• W168986412 cites W2017520388 @default.
• W168986412 cites W2020569205 @default.
• W168986412 cites W2021074141 @default.
• W168986412 cites W2021822056 @default.
• W168986412 cites W2023559004 @default.
• W168986412 cites W2027364545 @default.
• W168986412 cites W2031045153 @default.
• W168986412 cites W2031202761 @default.
• W168986412 cites W2033450022 @default.
• W168986412 cites W2034305179 @default.
• W168986412 cites W2034586725 @default.
• W168986412 cites W2035158298 @default.
• W168986412 cites W2035570040 @default.
• W168986412 cites W2035739216 @default.
• W168986412 cites W2039102895 @default.
• W168986412 cites W2041042935 @default.
• W168986412 cites W204218960 @default.
• W168986412 cites W2043912701 @default.
• W168986412 cites W2044097698 @default.
• W168986412 cites W2046222585 @default.
• W168986412 cites W2046577485 @default.
• W168986412 cites W2046605974 @default.
• W168986412 cites W2046968494 @default.
• W168986412 cites W2047233465 @default.
• W168986412 cites W2047774312 @default.
• W168986412 cites W2048013672 @default.
• W168986412 cites W2051336083 @default.
• W168986412 cites W2051356295 @default.
• W168986412 cites W2053863608 @default.
• W168986412 cites W2054189266 @default.
• W168986412 cites W2057398422 @default.
• W168986412 cites W2059765238 @default.
• W168986412 cites W2064088579 @default.
• W168986412 cites W2065279754 @default.
• W168986412 cites W2066679995 @default.
• W168986412 cites W2069040800 @default.
• W168986412 cites W2070454025 @default.
• W168986412 cites W2070618971 @default.
• W168986412 cites W2076841009 @default.
• W168986412 cites W2077008485 @default.
• W168986412 cites W207904371 @default.
• W168986412 cites W2079447585 @default.
• W168986412 cites W2079789063 @default.
• W168986412 cites W2080121931 @default.
• W168986412 cites W2080956673 @default.
• W168986412 cites W2081042239 @default.
• W168986412 cites W2081165340 @default.
• W168986412 cites W2082471334 @default.
• W168986412 cites W2083771700 @default.
• W168986412 cites W2086173738 @default.
• W168986412 cites W2086309846 @default.
• W168986412 cites W2088450189 @default.
• W168986412 cites W2090162165 @default.
• W168986412 cites W2091848725 @default.

• next