FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W16900533> ?p ?o ?g. }

• W16900533 endingPage "4" @default.
• W16900533 startingPage "42" @default.
• W16900533 abstract "To study the incidence, risk factors and prognosis of central nervous system (CNS) complications after hematopoietic stem cell transplantation (HSCT) in order to prevent or reduce its occurrence, provide better diagnosis and treatment and improve the survival of the patients.A total of 640 patients who consecutively underwent HSCT in our hospital between May 2001 and December 2007 were included. The clinical outcomes of the patients who developed CNS complications were analyzed.The patients received stem cells from haploidentical family members (Haplo, n = 289), identical siblings (IS, n = 237), unrelated donors (URD, n = 83), unrelated cord blood (n = 14), syngeneic siblings (n = 9) or autologous peripheral blood (n = 8). Fifty-seven of 640 patients (8.9%) developed CNS complications. The incidences were 12.0%, 13.5% and 3.4% in URD-HSCT, Haplo-HSCT and IS-HSCT respectively (P < 0.001). The incidences of CNS complications were 19.4% and 8.3% in cases who received or did not receive conditioning with TBI (P = 0.047). There was no significant difference in the incidences of CNS complications between children (15.3%) and adults (8.3%) (P = 0.072). Similar incidences of CNS complications were seen in patients with hematological malignancies (8.9%) and non-malignant hematological disorders (7.7%) (P = 1.000). Five of the 57 patients developed two kinds of CNS complications. The patterns of CNS complications included relapse (17 cases), infections (15 cases), cyclosporine or FK506 encephalopathy (9 cases), cerebral hemorrhage (8 cases), cerebral infarction (2 cases), Wernicke's encephalopathy (1 case), skull fracture (1 case), drug-related meningitis (1 case), hepatic encephalopathy (3 cases), post-transplant lymphoproliferative disorder (1 case) and undetermined causes (4 cases). The overall mortality in the patients who developed CNS complications was 57.9% and 66.7% of them died of CNS complications.CNS complications are not uncommon after HSCT and they have high mortality and poor prognosis. Our data suggest that haplo-HSCT, URD-HSCT and conditioning with TBI, but not the age and types of hematological diseases are the risk factors for development of CNS complications. Relapse and infections are the most common CNS complications in HSCT recipients. Early diagnosis and appropriate management are crucial to the improvement of clinical outcomes in these patients." @default.
• W16900533 created "2016-06-24" @default.
• W16900533 creator A5013836476 @default.
• W16900533 creator A5021699314 @default.
• W16900533 creator A5035705032 @default.
• W16900533 creator A5072543271 @default.
• W16900533 creator A5086991187 @default.
• W16900533 creator A5088706496 @default.
• W16900533 date "2010-01-01" @default.
• W16900533 modified "2023-09-22" @default.
• W16900533 title "[A study of the central nervous system complications after hematopoietic stem cell transplantation.]." @default.
• W16900533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20356481" @default.
• W16900533 hasPublicationYear "2010" @default.
• W16900533 type Work @default.
• W16900533 sameAs 16900533 @default.
• W16900533 citedByCount "2" @default.
• W16900533 countsByYear W169005332017 @default.
• W16900533 crossrefType "journal-article" @default.
• W16900533 hasAuthorship W16900533A5013836476 @default.
• W16900533 hasAuthorship W16900533A5021699314 @default.
• W16900533 hasAuthorship W16900533A5035705032 @default.
• W16900533 hasAuthorship W16900533A5072543271 @default.
• W16900533 hasAuthorship W16900533A5086991187 @default.
• W16900533 hasAuthorship W16900533A5088706496 @default.
• W16900533 hasConcept C120665830 @default.
• W16900533 hasConcept C121332964 @default.
• W16900533 hasConcept C126322002 @default.
• W16900533 hasConcept C141071460 @default.
• W16900533 hasConcept C187212893 @default.
• W16900533 hasConcept C2777408962 @default.
• W16900533 hasConcept C2778621155 @default.
• W16900533 hasConcept C2911091166 @default.
• W16900533 hasConcept C529278444 @default.
• W16900533 hasConcept C61511704 @default.
• W16900533 hasConcept C71924100 @default.
• W16900533 hasConceptScore W16900533C120665830 @default.
• W16900533 hasConceptScore W16900533C121332964 @default.
• W16900533 hasConceptScore W16900533C126322002 @default.
• W16900533 hasConceptScore W16900533C141071460 @default.
• W16900533 hasConceptScore W16900533C187212893 @default.
• W16900533 hasConceptScore W16900533C2777408962 @default.
• W16900533 hasConceptScore W16900533C2778621155 @default.
• W16900533 hasConceptScore W16900533C2911091166 @default.
• W16900533 hasConceptScore W16900533C529278444 @default.
• W16900533 hasConceptScore W16900533C61511704 @default.
• W16900533 hasConceptScore W16900533C71924100 @default.
• W16900533 hasIssue "1" @default.
• W16900533 hasLocation W169005331 @default.
• W16900533 hasOpenAccess W16900533 @default.
• W16900533 hasPrimaryLocation W169005331 @default.
• W16900533 hasRelatedWork W2005549555 @default.
• W16900533 hasRelatedWork W2010256720 @default.
• W16900533 hasRelatedWork W2254190504 @default.
• W16900533 hasRelatedWork W2255212113 @default.
• W16900533 hasRelatedWork W2417348045 @default.
• W16900533 hasRelatedWork W2419234080 @default.
• W16900533 hasRelatedWork W2582484320 @default.
• W16900533 hasRelatedWork W2587535732 @default.
• W16900533 hasRelatedWork W2588242003 @default.
• W16900533 hasRelatedWork W2913413652 @default.
• W16900533 hasRelatedWork W2945574845 @default.
• W16900533 hasRelatedWork W2970519793 @default.
• W16900533 hasRelatedWork W2979943598 @default.
• W16900533 hasRelatedWork W2980620545 @default.
• W16900533 hasRelatedWork W3030443840 @default.
• W16900533 hasRelatedWork W3030518282 @default.
• W16900533 hasRelatedWork W3032007540 @default.
• W16900533 hasRelatedWork W3032516621 @default.
• W16900533 hasRelatedWork W3043775916 @default.
• W16900533 hasRelatedWork W3107222638 @default.
• W16900533 hasVolume "49" @default.
• W16900533 isParatext "false" @default.
• W16900533 isRetracted "false" @default.
• W16900533 magId "16900533" @default.
• W16900533 workType "article" @default.