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- W1690318953 abstract "The discovery of the role of α-synuclein in the pathogenesis of Parkinson’s disease (PD) has opened new possibilities for the development of more authentic models of Parkinson’s disease. Recombinant adeno-associated virus (AAV) and lentivirus (LV) vectors are efficient tools for expression of genes locally in subsets of neurons in the brain and can be used to express human wild-type or mutated α-synuclein selectively in midbrain dopamine neurons. Using this approach, it is possible to trigger extensive PD-like cellular and axonal pathologies in the nigrostriatal projection, involving abnormal protein aggregation, neuronal dysfunction, and cell death that develop progressively over time. Targeted overexpression of human α-synuclein in midbrain dopamine neurons, using AAV vectors, reproduces many of the characteristic features of the human disease and provides, for the first time, a model of progressive PD that can be applied to both rodents and primates." @default.
- W1690318953 created "2016-06-24" @default.
- W1690318953 creator A5047762447 @default.
- W1690318953 creator A5050850243 @default.
- W1690318953 creator A5061597136 @default.
- W1690318953 creator A5083016310 @default.
- W1690318953 date "2010-01-01" @default.
- W1690318953 modified "2023-10-12" @default.
- W1690318953 title "Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson’s disease" @default.
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