FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W169096987> ?p ?o ?g. }

• W169096987 endingPage "115" @default.
• W169096987 startingPage "1097" @default.
• W169096987 abstract "To describe the abnormal phenotype in retinal pigment epithelium (RPE) and neural retina of vitiligo mutant mice from embryonic stages to old age.Eyes of wild-type controls and congenic vitiligo mutants were examined by light and electron microscopy from embryonic day (E) 12 to 2 years of age. The amount and distribution of pigment in the RPE was studied in wholemounts.Earliest phenotypic expression of mivit is seen in the RPE, which is abnormally multilayered dorsally at E12 to E13, and contains both hyperpigmented and hypopigmented patches. Postnatally, most RPE cells have abnormally short, compact, apical microvilli not containing melanosomes and not interdigitating with rod outer segments (ROS). Rod outer segments begin to degenerate relatively late, at approximately postnatal day (P) 30, and fragments accumulate in the subretinal space; photoreceptor nuclei decrease in number progressively from approximately P60 to P500. Retinal detachment, more prominent than in most other retinal degenerations, begins as ROS break up. Additional unusual events are the appearance of macrophage-like cells in the subretinal space by P21 to P60 and extensive shedding of photoreceptor nuclei across the external limiting membrane and into the subretinal space from approximately P180 to P500. Photoreceptor cell degeneration follows a radial gradient, more severe centrally, and is more advanced superiorly than inferiorly. By 2 years, almost all rod and cone cells are gone, and the residual neural retina is invaded by heavily pigmented cells.The initial ocular target of the mivit gene is the RPE, which is abnormal for many weeks before photoreceptor cells differentiate and become demonstrably affected. The authors hypothesize that the slowly progressive photoreceptor cell degeneration is secondary to abnormal function of the RPE. This mutation serves to refocus attention on critical influences of the RPE on function and maintenance of photoreceptor cells." @default.
• W169096987 created "2016-06-24" @default.
• W169096987 creator A5010524054 @default.
• W169096987 creator A5023726429 @default.
• W169096987 creator A5069613947 @default.
• W169096987 date "1996-05-01" @default.
• W169096987 modified "2023-09-24" @default.
• W169096987 title "Pigment epithelial and retinal phenotypes in the vitiligo mivit, mutant mouse." @default.
• W169096987 cites W109863923 @default.
• W169096987 cites W110541417 @default.
• W169096987 cites W1263994307 @default.
• W169096987 cites W140008824 @default.
• W169096987 cites W141195243 @default.
• W169096987 cites W142975357 @default.
• W169096987 cites W147269877 @default.
• W169096987 cites W1493943318 @default.
• W169096987 cites W1498567414 @default.
• W169096987 cites W1520755299 @default.
• W169096987 cites W171863589 @default.
• W169096987 cites W178744500 @default.
• W169096987 cites W1898123183 @default.
• W169096987 cites W192356983 @default.
• W169096987 cites W1968970621 @default.
• W169096987 cites W1979902384 @default.
• W169096987 cites W1983681542 @default.
• W169096987 cites W2013778872 @default.
• W169096987 cites W2019321988 @default.
• W169096987 cites W2021124272 @default.
• W169096987 cites W2022083096 @default.
• W169096987 cites W2029707090 @default.
• W169096987 cites W2035825974 @default.
• W169096987 cites W2040586108 @default.
• W169096987 cites W2061145220 @default.
• W169096987 cites W2061192937 @default.
• W169096987 cites W2061301279 @default.
• W169096987 cites W2064139298 @default.
• W169096987 cites W2073772356 @default.
• W169096987 cites W2076867944 @default.
• W169096987 cites W2083062636 @default.
• W169096987 cites W2090518130 @default.
• W169096987 cites W2094942321 @default.
• W169096987 cites W2114029080 @default.
• W169096987 cites W2125842849 @default.
• W169096987 cites W2126577146 @default.
• W169096987 cites W2144809232 @default.
• W169096987 cites W2145297890 @default.
• W169096987 cites W2148608417 @default.
• W169096987 cites W2286143610 @default.
• W169096987 cites W2436746132 @default.
• W169096987 cites W2589071211 @default.
• W169096987 cites W66541472 @default.
• W169096987 cites W77228969 @default.
• W169096987 cites W9625158 @default.
• W169096987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8631625" @default.
• W169096987 hasPublicationYear "1996" @default.
• W169096987 type Work @default.
• W169096987 sameAs 169096987 @default.
• W169096987 citedByCount "7" @default.
• W169096987 countsByYear W1690969872017 @default.
• W169096987 countsByYear W1690969872018 @default.
• W169096987 crossrefType "journal-article" @default.
• W169096987 hasAuthorship W169096987A5010524054 @default.
• W169096987 hasAuthorship W169096987A5023726429 @default.
• W169096987 hasAuthorship W169096987A5069613947 @default.
• W169096987 hasConcept C104317684 @default.
• W169096987 hasConcept C105702510 @default.
• W169096987 hasConcept C107538193 @default.
• W169096987 hasConcept C127716648 @default.
• W169096987 hasConcept C142724271 @default.
• W169096987 hasConcept C145103041 @default.
• W169096987 hasConcept C169760540 @default.
• W169096987 hasConcept C2777093970 @default.
• W169096987 hasConcept C2778024200 @default.
• W169096987 hasConcept C2780827179 @default.
• W169096987 hasConcept C2781040256 @default.
• W169096987 hasConcept C54355233 @default.
• W169096987 hasConcept C55493867 @default.
• W169096987 hasConcept C71924100 @default.
• W169096987 hasConcept C86803240 @default.
• W169096987 hasConcept C94435474 @default.
• W169096987 hasConcept C95444343 @default.
• W169096987 hasConceptScore W169096987C104317684 @default.
• W169096987 hasConceptScore W169096987C105702510 @default.
• W169096987 hasConceptScore W169096987C107538193 @default.
• W169096987 hasConceptScore W169096987C127716648 @default.
• W169096987 hasConceptScore W169096987C142724271 @default.
• W169096987 hasConceptScore W169096987C145103041 @default.
• W169096987 hasConceptScore W169096987C169760540 @default.
• W169096987 hasConceptScore W169096987C2777093970 @default.
• W169096987 hasConceptScore W169096987C2778024200 @default.
• W169096987 hasConceptScore W169096987C2780827179 @default.
• W169096987 hasConceptScore W169096987C2781040256 @default.
• W169096987 hasConceptScore W169096987C54355233 @default.
• W169096987 hasConceptScore W169096987C55493867 @default.
• W169096987 hasConceptScore W169096987C71924100 @default.
• W169096987 hasConceptScore W169096987C86803240 @default.
• W169096987 hasConceptScore W169096987C94435474 @default.
• W169096987 hasConceptScore W169096987C95444343 @default.

• next