FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1691455568> ?p ?o ?g. }

• W1691455568 endingPage "242" @default.
• W1691455568 startingPage "237" @default.
• W1691455568 abstract "Alkaline sphingomyelinase, an enzyme found exclusively in bile and the intestinal brush border, hydrolyzes sphingomyelin into ceramide, sphingosine and sphingosine-1-phosphate, thereby inducing epithelial apoptosis. Reduced levels of alkaline sphingomyelinase have been found in premalignant and malignant intestinal epithelia and in ulcerative colitis tissue. Probiotic bacteria can be a source of sphingomyelinase.To determine the effect of VSL#3 probiotic therapy on mucosal levels of alkaline sphingomyelinase, both in a mouse model of colitis and in patients with ulcerative colitis.Interleukin-10 gene-deficient (IL10KO) and wild type control mice were treated with VSL#3 (10(9) colony-forming units per day) for three weeks, after which alkaline sphingomyelinase activity was measured in ileal and colonic tissue. As well, 15 patients with ulcerative colitis were treated with VSL#3 (900 billion bacteria two times per day for five weeks). Alkaline sphingomyelinase activity was measured through biopsies and comparison of ulcerative colitis disease activity index scores obtained before and after treatment.Lowered alkaline sphingomyelinase levels were seen in the colon (P=0.02) and ileum (P=0.04) of IL10KO mice, as compared with controls. Treatment of these mice with VSL#3 resulted in upregulation of mucosal alkaline sphingomyelinase activity in both the colon (P=0.04) and the ileum (P=0.01). VSL#3 treatment of human patients who had ulcerative colitis decreased mean (+/- SEM) ulcerative colitis disease activity index scores from 5.3+/-1.8946 to 0.70+/-0.34 (P=0.02) and increased mucosal alkaline sphingomyelinase activity.Mucosal alkaline sphingomyelinase activity is reduced in the intestine of IL10KO mice with colitis and in humans with ulcerative colitis. VSL#3 probiotic therapy upregulates mucosal alkaline sphingomyelinase activity." @default.
• W1691455568 created "2016-06-24" @default.
• W1691455568 creator A5021559660 @default.
• W1691455568 creator A5042395562 @default.
• W1691455568 creator A5044671434 @default.
• W1691455568 creator A5055795633 @default.
• W1691455568 creator A5056897729 @default.
• W1691455568 creator A5060220822 @default.
• W1691455568 creator A5070055399 @default.
• W1691455568 creator A5077762166 @default.
• W1691455568 creator A5078587078 @default.
• W1691455568 creator A5082311020 @default.
• W1691455568 date "2008-01-01" @default.
• W1691455568 modified "2023-09-25" @default.
• W1691455568 title "VSL#3 Probiotic Upregulates Intestinal Mucosal Alkaline Sphingomyelinase and Reduces Inflammation" @default.
• W1691455568 cites W1552016321 @default.
• W1691455568 cites W1662689772 @default.
• W1691455568 cites W1963719250 @default.
• W1691455568 cites W1969349351 @default.
• W1691455568 cites W1973412345 @default.
• W1691455568 cites W1974620451 @default.
• W1691455568 cites W1980282450 @default.
• W1691455568 cites W1993686652 @default.
• W1691455568 cites W1993863553 @default.
• W1691455568 cites W2009065572 @default.
• W1691455568 cites W2010298858 @default.
• W1691455568 cites W2021789531 @default.
• W1691455568 cites W2022407649 @default.
• W1691455568 cites W2040821545 @default.
• W1691455568 cites W2060700279 @default.
• W1691455568 cites W2064009012 @default.
• W1691455568 cites W2066111639 @default.
• W1691455568 cites W2078496970 @default.
• W1691455568 cites W2078582547 @default.
• W1691455568 cites W2079021603 @default.
• W1691455568 cites W2089275594 @default.
• W1691455568 cites W2092231441 @default.
• W1691455568 cites W2099577477 @default.
• W1691455568 cites W2106169114 @default.
• W1691455568 cites W2112851606 @default.
• W1691455568 cites W2114672214 @default.
• W1691455568 cites W2121650731 @default.
• W1691455568 cites W2128821991 @default.
• W1691455568 cites W2137686315 @default.
• W1691455568 cites W2139759128 @default.
• W1691455568 cites W2147068566 @default.
• W1691455568 cites W2156685281 @default.
• W1691455568 cites W2163415354 @default.
• W1691455568 cites W2168688666 @default.
• W1691455568 cites W2171896334 @default.
• W1691455568 cites W238860423 @default.
• W1691455568 cites W3027029841 @default.
• W1691455568 doi "https://doi.org/10.1155/2008/520383" @default.
• W1691455568 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2662197" @default.
• W1691455568 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18354751" @default.
• W1691455568 hasPublicationYear "2008" @default.
• W1691455568 type Work @default.
• W1691455568 sameAs 1691455568 @default.
• W1691455568 citedByCount "73" @default.
• W1691455568 countsByYear W16914555682012 @default.
• W1691455568 countsByYear W16914555682013 @default.
• W1691455568 countsByYear W16914555682014 @default.
• W1691455568 countsByYear W16914555682015 @default.
• W1691455568 countsByYear W16914555682016 @default.
• W1691455568 countsByYear W16914555682017 @default.
• W1691455568 countsByYear W16914555682018 @default.
• W1691455568 countsByYear W16914555682020 @default.
• W1691455568 countsByYear W16914555682021 @default.
• W1691455568 countsByYear W16914555682022 @default.
• W1691455568 countsByYear W16914555682023 @default.
• W1691455568 crossrefType "journal-article" @default.
• W1691455568 hasAuthorship W1691455568A5021559660 @default.
• W1691455568 hasAuthorship W1691455568A5042395562 @default.
• W1691455568 hasAuthorship W1691455568A5044671434 @default.
• W1691455568 hasAuthorship W1691455568A5055795633 @default.
• W1691455568 hasAuthorship W1691455568A5056897729 @default.
• W1691455568 hasAuthorship W1691455568A5060220822 @default.
• W1691455568 hasAuthorship W1691455568A5070055399 @default.
• W1691455568 hasAuthorship W1691455568A5077762166 @default.
• W1691455568 hasAuthorship W1691455568A5078587078 @default.
• W1691455568 hasAuthorship W1691455568A5082311020 @default.
• W1691455568 hasBestOaLocation W16914555681 @default.
• W1691455568 hasConcept C126322002 @default.
• W1691455568 hasConcept C170493617 @default.
• W1691455568 hasConcept C185592680 @default.
• W1691455568 hasConcept C190283241 @default.
• W1691455568 hasConcept C2775862500 @default.
• W1691455568 hasConcept C2777226302 @default.
• W1691455568 hasConcept C2777851122 @default.
• W1691455568 hasConcept C2778163477 @default.
• W1691455568 hasConcept C2778703144 @default.
• W1691455568 hasConcept C2779134260 @default.
• W1691455568 hasConcept C2780255968 @default.
• W1691455568 hasConcept C2780479503 @default.
• W1691455568 hasConcept C2781070647 @default.
• W1691455568 hasConcept C2781457462 @default.
• W1691455568 hasConcept C523546767 @default.
• W1691455568 hasConcept C54355233 @default.

• next