FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1691701355> ?p ?o ?g. }

• W1691701355 endingPage "902" @default.
• W1691701355 startingPage "890" @default.
• W1691701355 abstract "Abstract Adenosine and ATP, via their specific P1 and P2 receptors, modulate a wide variety of cellular and tissue functions, playing a neuroprotective or neurodegenerative role in brain damage conditions. Although, in general, adenosine inhibits excitability and ATP functions as an excitatory transmitter in the central nervous system, recent data suggest the existence of a heterodimerization and a functional interaction between P1 and P2 receptors in the brain. In particular, interactions of adenosine A 1 and P2Y 1 receptors may play important roles in the purinergic signalling cascade. In the present work, we investigated the subcellular localization/co‐localization of the receptors and their functional cross‐talk at the membrane level in Wistar rat hippocampus. This is a particularly vulnerable brain area, which is sensitive to adenosine‐ and ATP‐mediated control of glutamatergic transmission. The postembedding immunogold electron microscopy technique showed that the two receptors are co‐localized at the synaptic membranes and surrounding astroglial membranes of glutamatergic synapses. To investigate the functional cross‐talk between the two types of purinergic receptors, we evaluated the reciprocal effects of their activation on their G protein coupling. P2Y 1 receptor stimulation impaired the potency of A 1 receptor coupling to G protein, whereas the stimulation of A 1 receptors increased the functional responsiveness of P2Y 1 receptors. The results demonstrated an A 1 –P2Y 1 receptor co‐localization at glutamatergic synapses and surrounding astrocytes and a functional interaction between these receptors in hippocampus, suggesting ATP and adenosine can interact in purine‐mediated signalling. This may be particularly important during pathological conditions, when large amounts of these mediators are released." @default.
• W1691701355 created "2016-06-24" @default.
• W1691701355 creator A5026476213 @default.
• W1691701355 creator A5031611004 @default.
• W1691701355 creator A5050408597 @default.
• W1691701355 creator A5059361843 @default.
• W1691701355 creator A5067808979 @default.
• W1691701355 date "2007-08-01" @default.
• W1691701355 modified "2023-10-10" @default.
• W1691701355 title "Co-localization and functional cross-talk between A1 and P2Y1 purine receptors in rat hippocampus" @default.
• W1691701355 cites W1257992088 @default.
• W1691701355 cites W1494070440 @default.
• W1691701355 cites W1575672758 @default.
• W1691701355 cites W1582253391 @default.
• W1691701355 cites W1582798416 @default.
• W1691701355 cites W1593719233 @default.
• W1691701355 cites W1598801167 @default.
• W1691701355 cites W1608256683 @default.
• W1691701355 cites W1653077694 @default.
• W1691701355 cites W1862204138 @default.
• W1691701355 cites W1880364852 @default.
• W1691701355 cites W1886164324 @default.
• W1691701355 cites W1894872962 @default.
• W1691701355 cites W1963692643 @default.
• W1691701355 cites W1966042335 @default.
• W1691701355 cites W1968258145 @default.
• W1691701355 cites W1968906899 @default.
• W1691701355 cites W1969594545 @default.
• W1691701355 cites W1971552691 @default.
• W1691701355 cites W1972059769 @default.
• W1691701355 cites W1976486369 @default.
• W1691701355 cites W1979693948 @default.
• W1691701355 cites W1980746508 @default.
• W1691701355 cites W1980900081 @default.
• W1691701355 cites W1982199478 @default.
• W1691701355 cites W1986437824 @default.
• W1691701355 cites W1986565426 @default.
• W1691701355 cites W1987364693 @default.
• W1691701355 cites W1988661280 @default.
• W1691701355 cites W1998040264 @default.
• W1691701355 cites W2000068729 @default.
• W1691701355 cites W2003277020 @default.
• W1691701355 cites W2003565588 @default.
• W1691701355 cites W2004727202 @default.
• W1691701355 cites W2004977662 @default.
• W1691701355 cites W2005786584 @default.
• W1691701355 cites W2006842487 @default.
• W1691701355 cites W2007270755 @default.
• W1691701355 cites W2014687654 @default.
• W1691701355 cites W2019951943 @default.
• W1691701355 cites W2021213286 @default.
• W1691701355 cites W2022992564 @default.
• W1691701355 cites W2028582108 @default.
• W1691701355 cites W2030352252 @default.
• W1691701355 cites W2033118995 @default.
• W1691701355 cites W2034800672 @default.
• W1691701355 cites W2035107045 @default.
• W1691701355 cites W2035750459 @default.
• W1691701355 cites W2035907673 @default.
• W1691701355 cites W2035938586 @default.
• W1691701355 cites W2043744835 @default.
• W1691701355 cites W2044175751 @default.
• W1691701355 cites W2047595976 @default.
• W1691701355 cites W2054924316 @default.
• W1691701355 cites W2062768744 @default.
• W1691701355 cites W2067292092 @default.
• W1691701355 cites W2069222131 @default.
• W1691701355 cites W2070357113 @default.
• W1691701355 cites W2070582319 @default.
• W1691701355 cites W2074067362 @default.
• W1691701355 cites W2075939908 @default.
• W1691701355 cites W2082220840 @default.
• W1691701355 cites W2088728113 @default.
• W1691701355 cites W2091989305 @default.
• W1691701355 cites W2094737861 @default.
• W1691701355 cites W2106307937 @default.
• W1691701355 cites W2109740923 @default.
• W1691701355 cites W2112650290 @default.
• W1691701355 cites W2123609069 @default.
• W1691701355 cites W2126553670 @default.
• W1691701355 cites W2127325448 @default.
• W1691701355 cites W2127942504 @default.
• W1691701355 cites W2128725190 @default.
• W1691701355 cites W2130876203 @default.
• W1691701355 cites W2134230622 @default.
• W1691701355 cites W2135148300 @default.
• W1691701355 cites W2135842147 @default.
• W1691701355 cites W2138599948 @default.
• W1691701355 cites W2145758516 @default.
• W1691701355 cites W2150918592 @default.
• W1691701355 cites W2153900861 @default.
• W1691701355 cites W2158833117 @default.
• W1691701355 cites W2160500827 @default.
• W1691701355 cites W2160606813 @default.
• W1691701355 cites W2165004755 @default.
• W1691701355 cites W2174668858 @default.
• W1691701355 cites W2344024966 @default.
• W1691701355 cites W2428696382 @default.

• next