FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1691743927> ?p ?o ?g. }

• W1691743927 abstract "childhood trauma and psychosis, however the exact mechanism underlying this association remains elusive. Several psychological models have been postulated, but data from large, representative samples specifically investigating possible pathways are scarce. Methods: n two longitudinal population-based studies (NEMESIS-1, N=7076 and NEMESIS-2, N=6646) and one longitudinal cohort study (G.R.O.U.P., including psychotic disorder patients [N=1119], their unaffected siblings [N=1057] and healthy controls [N=589]), childhood trauma, psychotic symptoms and other psychopathology were assessed. In all three studies, differences of effects of trauma with or without intent associated with psychosis were investigated. In NEMESIS-1 and NEMESIS-2, other theories were tested involving specificity of associations of particular trauma types (i.e. physical, sexual or psychological abuse, emotional neglect, growing up in foster care or death of a loved one) and particular psychotic symptoms (i.e. hallucinations in general, auditory-verbal hallucinations, delusions in general or paranoia). In NEMESIS-2, it was investigated whether exposure to childhood trauma was associated with a number of affective symptoms indicative of hopelessness for the future and low self-esteem (based on the ’social defeat’ hypothesis of psychosis), and whether these symptoms in turn were mediators in the association with psychosis. Results: In NEMESIS-1 and NEMESIS-2, trauma with an intention to harm (psychological, sexual or physical abuse) showed a stronger association with psychotic experiences than trauma without intent (death of a loved one) (χ2=58.62, df=1, p<0.001). Similar results for psychotic disorder patients were found in the GROUP study: physical, emotional and sexual abuse was associated more strongly with psychotic symptoms than physical or emotional neglect (B 0.24, CI 0.09–0.40, p=0.002). In NEMESIS-2, symptoms indicative of social defeat (e.g. hopelessness about future and loss of selfconfidence) were strong and separate mediators in the association between childhood trauma and psychotic experiences (proportion of mediating effect 31%) as well as between childhood trauma and the narrower phenotype of psychotic disorder (proportion of mediating effect 87%). No evidence was found indicating that any of the trauma types showed stronger associations with either hallucinations in general, auditory-verbal hallucinations, delusions in general or paranoia. Discussion: Intention-to-harm, possibly through a mechanism of “social defeat”, is the key component which links childhood trauma to psychotic experiences in adulthood. No evidence was found to support psychological theories regarding specific associations between particular types of trauma and particular psychotic symptoms." @default.
• W1691743927 created "2016-06-24" @default.
• W1691743927 creator A5012022646 @default.
• W1691743927 creator A5012320380 @default.
• W1691743927 creator A5018189291 @default.
• W1691743927 creator A5027596082 @default.
• W1691743927 creator A5075556991 @default.
• W1691743927 creator A5081893626 @default.
• W1691743927 creator A5087482611 @default.
• W1691743927 creator A5087635866 @default.
• W1691743927 creator A5088036425 @default.
• W1691743927 creator A5090649309 @default.
• W1691743927 date "2014-06-03" @default.
• W1691743927 modified "2023-09-24" @default.
• W1691743927 title "Negative modulation of the synaptic vesicle protein (SV2A): a new pharmacological target for cognitive deficit associated with schizophrenia" @default.
• W1691743927 doi "https://doi.org/10.7490/f1000research.1095560.1" @default.
• W1691743927 hasPublicationYear "2014" @default.
• W1691743927 type Work @default.
• W1691743927 sameAs 1691743927 @default.
• W1691743927 citedByCount "0" @default.
• W1691743927 crossrefType "journal-article" @default.
• W1691743927 hasAuthorship W1691743927A5012022646 @default.
• W1691743927 hasAuthorship W1691743927A5012320380 @default.
• W1691743927 hasAuthorship W1691743927A5018189291 @default.
• W1691743927 hasAuthorship W1691743927A5027596082 @default.
• W1691743927 hasAuthorship W1691743927A5075556991 @default.
• W1691743927 hasAuthorship W1691743927A5081893626 @default.
• W1691743927 hasAuthorship W1691743927A5087482611 @default.
• W1691743927 hasAuthorship W1691743927A5087635866 @default.
• W1691743927 hasAuthorship W1691743927A5088036425 @default.
• W1691743927 hasAuthorship W1691743927A5090649309 @default.
• W1691743927 hasConcept C118552586 @default.
• W1691743927 hasConcept C123273963 @default.
• W1691743927 hasConcept C15744967 @default.
• W1691743927 hasConcept C190385971 @default.
• W1691743927 hasConcept C2776289891 @default.
• W1691743927 hasConcept C2776412080 @default.
• W1691743927 hasConcept C2779727114 @default.
• W1691743927 hasConcept C2781105514 @default.
• W1691743927 hasConcept C2908647359 @default.
• W1691743927 hasConcept C2992354236 @default.
• W1691743927 hasConcept C3017944768 @default.
• W1691743927 hasConcept C70410870 @default.
• W1691743927 hasConcept C71924100 @default.
• W1691743927 hasConcept C99454951 @default.
• W1691743927 hasConceptScore W1691743927C118552586 @default.
• W1691743927 hasConceptScore W1691743927C123273963 @default.
• W1691743927 hasConceptScore W1691743927C15744967 @default.
• W1691743927 hasConceptScore W1691743927C190385971 @default.
• W1691743927 hasConceptScore W1691743927C2776289891 @default.
• W1691743927 hasConceptScore W1691743927C2776412080 @default.
• W1691743927 hasConceptScore W1691743927C2779727114 @default.
• W1691743927 hasConceptScore W1691743927C2781105514 @default.
• W1691743927 hasConceptScore W1691743927C2908647359 @default.
• W1691743927 hasConceptScore W1691743927C2992354236 @default.
• W1691743927 hasConceptScore W1691743927C3017944768 @default.
• W1691743927 hasConceptScore W1691743927C70410870 @default.
• W1691743927 hasConceptScore W1691743927C71924100 @default.
• W1691743927 hasConceptScore W1691743927C99454951 @default.
• W1691743927 hasLocation W16917439271 @default.
• W1691743927 hasOpenAccess W1691743927 @default.
• W1691743927 hasPrimaryLocation W16917439271 @default.
• W1691743927 hasRelatedWork W1585173580 @default.
• W1691743927 hasRelatedWork W184284683 @default.
• W1691743927 hasRelatedWork W184579764 @default.
• W1691743927 hasRelatedWork W1872072116 @default.
• W1691743927 hasRelatedWork W2008976175 @default.
• W1691743927 hasRelatedWork W2012690921 @default.
• W1691743927 hasRelatedWork W2028305434 @default.
• W1691743927 hasRelatedWork W2028554055 @default.
• W1691743927 hasRelatedWork W2052500414 @default.
• W1691743927 hasRelatedWork W2057478734 @default.
• W1691743927 hasRelatedWork W2059143392 @default.
• W1691743927 hasRelatedWork W2059337496 @default.
• W1691743927 hasRelatedWork W2071613912 @default.
• W1691743927 hasRelatedWork W2071679295 @default.
• W1691743927 hasRelatedWork W2134716410 @default.
• W1691743927 hasRelatedWork W2137924972 @default.
• W1691743927 hasRelatedWork W2150302044 @default.
• W1691743927 hasRelatedWork W2152919138 @default.
• W1691743927 hasRelatedWork W2314909470 @default.
• W1691743927 hasRelatedWork W2518980153 @default.
• W1691743927 hasVolume "5" @default.
• W1691743927 isParatext "false" @default.
• W1691743927 isRetracted "false" @default.
• W1691743927 magId "1691743927" @default.
• W1691743927 workType "article" @default.