FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1692050915> ?p ?o ?g. }

• W1692050915 endingPage "29" @default.
• W1692050915 startingPage "15" @default.
• W1692050915 abstract "Rituximab: An emerging therapeutic agent for kidney transplantation Joseph Kahwaji, Chris Tong, Stanley C Jordan, Ashley A VoComprehensive Transplant Center, Transplant immunology Laboratory, HLA Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, USAAbstract: Rituximab (anti-CD20, anti-B-cell) is now emerging as an important drug for modification of B-cell and antibody responses in solid-organ transplant recipients. Its uses are varied and range from facilitating desensitization and ABO blood group-incompatible transplantation to the treatment of antibody-mediated rejection (AMR), post-transplant lymphoproliferative disorder (PTLD), and recurrent glomerular diseases in the renal allograft. Despite these uses, prospective randomized trials are lacking. Only case reports exist in regards to its use in de novo and recurrent diseases in the renal allograft. Recent reports suggests that the addition of rituximab to intravenous immunoglobulin (IVIG) may have significant benefits for desensitization and treatment of AMR and chronic rejection. Current dosing recommendations are based on data from United States Food and Drug Administration-approved indications for treatment of B-cell lymphomas and rheumatoid arthritis. From the initial reported experience in solid organ transplant recipients, the drug is well tolerated and not associated with increased infectious risks. However, close monitoring for viral infections is recommended with rituximab use. The occurrence of progressive multifocal leukoencephalopathy (PML) has been reported with rituximab use. However, this is rare and not reported in the renal transplant population. Here we will review current information regarding the effectiveness of rituximab as an agent for desensitization of highly human leukocyte antigen-sensitized and ABO-incompatible transplant recipients and its use in treatment of AMR. In addition, the post-transplant use of rituximab for treatment of PTLD and for recurrent and de novo glomerulonephritis in the allograft will be discussed. In summary, we will make recommendations based on existing literature and our extensive experience at Cedars-Sinai Medical Center for using rituximab in renal transplantation.Keywords: kidney transplant, rituximab, desensitization, rejection, review" @default.
• W1692050915 created "2016-06-24" @default.
• W1692050915 creator A5034451765 @default.
• W1692050915 creator A5044616722 @default.
• W1692050915 creator A5071314630 @default.
• W1692050915 creator A5076738806 @default.
• W1692050915 date "2009-10-01" @default.
• W1692050915 modified "2023-10-16" @default.
• W1692050915 title "Rituximab: An emerging therapeutic agent for kidney transplantation" @default.
• W1692050915 cites W118889791 @default.
• W1692050915 cites W1511207488 @default.
• W1692050915 cites W1512745446 @default.
• W1692050915 cites W1543833158 @default.
• W1692050915 cites W1571413835 @default.
• W1692050915 cites W1796203810 @default.
• W1692050915 cites W1824943736 @default.
• W1692050915 cites W1854856869 @default.
• W1692050915 cites W1965622113 @default.
• W1692050915 cites W1966348678 @default.
• W1692050915 cites W1968102557 @default.
• W1692050915 cites W1968889356 @default.
• W1692050915 cites W1969640677 @default.
• W1692050915 cites W1975300245 @default.
• W1692050915 cites W1977557500 @default.
• W1692050915 cites W1978925768 @default.
• W1692050915 cites W1979794631 @default.
• W1692050915 cites W1981746816 @default.
• W1692050915 cites W1983005038 @default.
• W1692050915 cites W1983172429 @default.
• W1692050915 cites W1987068568 @default.
• W1692050915 cites W1987807800 @default.
• W1692050915 cites W1988157765 @default.
• W1692050915 cites W1989569525 @default.
• W1692050915 cites W1989894180 @default.
• W1692050915 cites W1989980624 @default.
• W1692050915 cites W1990693838 @default.
• W1692050915 cites W1992823373 @default.
• W1692050915 cites W1992883814 @default.
• W1692050915 cites W1993281387 @default.
• W1692050915 cites W1994630947 @default.
• W1692050915 cites W1995498454 @default.
• W1692050915 cites W1998522073 @default.
• W1692050915 cites W2000637969 @default.
• W1692050915 cites W2001321215 @default.
• W1692050915 cites W2003267481 @default.
• W1692050915 cites W2005671897 @default.
• W1692050915 cites W2006131551 @default.
• W1692050915 cites W2006326109 @default.
• W1692050915 cites W2007166703 @default.
• W1692050915 cites W2007350320 @default.
• W1692050915 cites W2016551261 @default.
• W1692050915 cites W2017776893 @default.
• W1692050915 cites W2022334249 @default.
• W1692050915 cites W2022620519 @default.
• W1692050915 cites W2023891464 @default.
• W1692050915 cites W2024382442 @default.
• W1692050915 cites W2025189432 @default.
• W1692050915 cites W2025611037 @default.
• W1692050915 cites W2031137577 @default.
• W1692050915 cites W2031276271 @default.
• W1692050915 cites W2031809342 @default.
• W1692050915 cites W2033195994 @default.
• W1692050915 cites W2036902478 @default.
• W1692050915 cites W2038277169 @default.
• W1692050915 cites W2038403701 @default.
• W1692050915 cites W2041352623 @default.
• W1692050915 cites W2044445861 @default.
• W1692050915 cites W2044611877 @default.
• W1692050915 cites W2046900942 @default.
• W1692050915 cites W2048139132 @default.
• W1692050915 cites W2051266349 @default.
• W1692050915 cites W2053683902 @default.
• W1692050915 cites W2055656354 @default.
• W1692050915 cites W2058424528 @default.
• W1692050915 cites W2059446551 @default.
• W1692050915 cites W2060766134 @default.
• W1692050915 cites W2065512309 @default.
• W1692050915 cites W2066846899 @default.
• W1692050915 cites W2067811565 @default.
• W1692050915 cites W2070239044 @default.
• W1692050915 cites W2074071648 @default.
• W1692050915 cites W2075061197 @default.
• W1692050915 cites W2076843879 @default.
• W1692050915 cites W2077075882 @default.
• W1692050915 cites W2077556139 @default.
• W1692050915 cites W2077570217 @default.
• W1692050915 cites W2080520212 @default.
• W1692050915 cites W2082973069 @default.
• W1692050915 cites W2083324079 @default.
• W1692050915 cites W2085915009 @default.
• W1692050915 cites W2087929136 @default.
• W1692050915 cites W2092628378 @default.
• W1692050915 cites W2094487124 @default.
• W1692050915 cites W2097429157 @default.
• W1692050915 cites W2099801548 @default.
• W1692050915 cites W2120706571 @default.
• W1692050915 cites W2121183119 @default.
• W1692050915 cites W2122536819 @default.

• next