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- W169353208 abstract "The authors have previously reported that VIP elevates intracellular cyclic AMP and inhibits activation of washed rabbit platelets induced by platelet activating factor. They have now examined VIP binding sites on intact rabbit platelets, using (/sup 125/I) VIP. Binding was: (1) saturable; (2) dependent on the temperature and duration of incubation, with maximal binding occurring after 15 min. at 4/sup 0/C; (3) directly proportional to the number of platelets; and (4) reversible. The ED/sub 50/ for the displacement of the binding by unlabeled VIP was 300 nM. The structurally unrelated peptides eledoisin, metenkephalin, neurotensin and insulin, at concentrations up to 5 ..mu..M, did not displace (/sup 125/I)VIP. The homologous peptides, secretin and PHI, however, displaced bound VIP with almost equal potency. They conclude that VIP-binding sites are present on rabbit platelets, that these receptors have relatively low affinity for VIP, and bind secretin and PHI with approximately equal affinity." @default.
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- W169353208 date "1986-03-05" @default.
- W169353208 modified "2023-09-28" @default.
- W169353208 title "Binding sites for vasoactive intestinal polypeptide (VIP) on washed rabbit platelets" @default.
- W169353208 hasPublicationYear "1986" @default.
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