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- W16941619 abstract "Discovery of the osteoclast differentiation factor RANKL (receptor activator of NF-κB ligand) has opened a new era in the understanding of mechanisms in osteoclast differentiation over the last decade. The discovery results in the development of a fully human anti-RANKL neutralizing monoclonal antibody (called denosumab) and denosumab has been approved for the treatment of osteoporosis in Europe and the US. Here I review a novel rapid bone loss model with GST (glutathione-S-transferase) -RANKL. Pharmacologic studies of candidates for the treatment of osteoporosis with this model can be done in short periods such as 3 days and a couple of weeks although it took several months in the conventional methods with ovariectomized (OVX) -rats. This model also is useful for the rapid analyses in the functions of osteoclasts in vivo . I am expecting the RANKL-induced bone loss model to be the gold standard in the animal osteoporosis model as well as OVX-rats in the near future." @default.
- W16941619 created "2016-06-24" @default.
- W16941619 creator A5089554151 @default.
- W16941619 date "2011-02-01" @default.
- W16941619 modified "2023-09-25" @default.
- W16941619 title "[Animal models for bone and joint disease. RANKL-injected bone loss model]." @default.
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