Matches in SemOpenAlex for { <https://semopenalex.org/work/W169429988> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W169429988 abstract "Na,K-ATPase is believed to be the receptor for digitalis glycosides, with binding site located in the ..cap alpha..-subunit. To identify this binding site, the enzyme was covalently labeled with a photoactive probe localized in C17 side group of the cardenolide ((/sup 3/H)24-azidodigitoxoside). /sup 3/H-labeled ..cap alpha..-subunit was purified, and subjected to trypsin digestion. Fractions containing /sup 3/H-labeled material were pooled. Amino acid sequence analysis of this material suggested the presence of two peptides (residues 68-146; residues 263-342). Additional studies have employed purification of the /sup 3/H-labeled material by chromatography on Sepharose-6B, and CNBr cleavage followed by chromatography on hydroxylapatite. Amino acid sequence analysis of the purified /sup 3/H-labeled peptide thus isolated indicated sequence containing amino acid residues 263-342. These data suggest that this is the peptide containing the digitalis genin binding site, and rule out such a role for the other peptide (amino acids 68 - 146). Preliminary data also hint that binding of the /sup 3/H-probe occurs at the leu residue in the sequence glu tyr thr try leu glu .. present in the peptide containing residues 263 - 342." @default.
- W169429988 created "2016-06-24" @default.
- W169429988 creator A5005593638 @default.
- W169429988 creator A5006001718 @default.
- W169429988 creator A5013073520 @default.
- W169429988 creator A5061182914 @default.
- W169429988 creator A5083060112 @default.
- W169429988 date "1987-05-01" @default.
- W169429988 modified "2023-09-24" @default.
- W169429988 title "Analysis of digitalis genin receptor site in Na,K-ATPase" @default.
- W169429988 hasPublicationYear "1987" @default.
- W169429988 type Work @default.
- W169429988 sameAs 169429988 @default.
- W169429988 citedByCount "0" @default.
- W169429988 crossrefType "journal-article" @default.
- W169429988 hasAuthorship W169429988A5005593638 @default.
- W169429988 hasAuthorship W169429988A5006001718 @default.
- W169429988 hasAuthorship W169429988A5013073520 @default.
- W169429988 hasAuthorship W169429988A5061182914 @default.
- W169429988 hasAuthorship W169429988A5083060112 @default.
- W169429988 hasConcept C104317684 @default.
- W169429988 hasConcept C107824862 @default.
- W169429988 hasConcept C167625842 @default.
- W169429988 hasConcept C181199279 @default.
- W169429988 hasConcept C185592680 @default.
- W169429988 hasConcept C2779281246 @default.
- W169429988 hasConcept C2780340462 @default.
- W169429988 hasConcept C2781338088 @default.
- W169429988 hasConcept C515207424 @default.
- W169429988 hasConcept C55493867 @default.
- W169429988 hasConcept C71240020 @default.
- W169429988 hasConceptScore W169429988C104317684 @default.
- W169429988 hasConceptScore W169429988C107824862 @default.
- W169429988 hasConceptScore W169429988C167625842 @default.
- W169429988 hasConceptScore W169429988C181199279 @default.
- W169429988 hasConceptScore W169429988C185592680 @default.
- W169429988 hasConceptScore W169429988C2779281246 @default.
- W169429988 hasConceptScore W169429988C2780340462 @default.
- W169429988 hasConceptScore W169429988C2781338088 @default.
- W169429988 hasConceptScore W169429988C515207424 @default.
- W169429988 hasConceptScore W169429988C55493867 @default.
- W169429988 hasConceptScore W169429988C71240020 @default.
- W169429988 hasLocation W1694299881 @default.
- W169429988 hasOpenAccess W169429988 @default.
- W169429988 hasPrimaryLocation W1694299881 @default.
- W169429988 hasRelatedWork W108747217 @default.
- W169429988 hasRelatedWork W1490136219 @default.
- W169429988 hasRelatedWork W1492177665 @default.
- W169429988 hasRelatedWork W1532341764 @default.
- W169429988 hasRelatedWork W155374160 @default.
- W169429988 hasRelatedWork W1736908815 @default.
- W169429988 hasRelatedWork W1973645653 @default.
- W169429988 hasRelatedWork W1977215949 @default.
- W169429988 hasRelatedWork W1996018521 @default.
- W169429988 hasRelatedWork W2003195273 @default.
- W169429988 hasRelatedWork W2025941397 @default.
- W169429988 hasRelatedWork W2027308417 @default.
- W169429988 hasRelatedWork W2058374294 @default.
- W169429988 hasRelatedWork W2092037376 @default.
- W169429988 hasRelatedWork W2128367215 @default.
- W169429988 hasRelatedWork W2301644892 @default.
- W169429988 hasRelatedWork W239668896 @default.
- W169429988 hasRelatedWork W2404223574 @default.
- W169429988 hasRelatedWork W2413641051 @default.
- W169429988 hasRelatedWork W641361935 @default.
- W169429988 isParatext "false" @default.
- W169429988 isRetracted "false" @default.
- W169429988 magId "169429988" @default.
- W169429988 workType "article" @default.