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• W1695091605 abstract "Metabolomics is the analysis of endogenous and exogenous low molecular mass metabolites within a cell, tissue, or biofluid of an organism in response to an external stressor. The sub-discipline of environmental metabolomics is the application of metabolomic techniques to analyze the interactions of organisms with their environment. There has been a rapid growth in environmental metabolomics over the past decade. This growth can be attributed to the comprehensive and rapid nature of nontargeted metabolomics and the ability to generate hypotheses involving complex environmental stressors, especially when the mode of action is unknown. Using a wide variety of model organisms, metabolomic studies have detected stress from abiotic factors such as xenobiotic exposure and temperature shifts as well as biotic stressors such as herbivory and competition. Nuclear magnetic resonance (NMR)-based metabolomics has been the dominant analytical platform used for environmental metabolomics studies, owing to its nonselectivity and ease of sample preparation. However, the number of mass spectrometry (MS)-based metabolomic studies is also increasing rapidly, owing to its high sensitivity for the detection of trace levels of metabolites. In this review, we provide an overview of the general experimental design, extraction methods, analytical instrumentation, and statistical methods used in environmental metabolomics. We then highlight some of the recent studies that have used metabolomics to elucidate hitherto unknown biochemical modes of actions of various environmental stressors to both terrestrial and aquatic organisms, as well as identify potential metabolite shifts as early bioindicators of these stressors. Through this, we emphasize the immense potential and versatility of environmental metabolomics as a routine tool for characterizing the responses of organisms to numerous types of environmental stressors." @default.
• W1695091605 created "2016-06-24" @default.
• W1695091605 creator A5006398803 @default.
• W1695091605 creator A5025438107 @default.
• W1695091605 creator A5036961612 @default.
• W1695091605 date "2013-09-01" @default.
• W1695091605 modified "2023-10-16" @default.
• W1695091605 title "Environmental metabolomics: an emerging approach to study organism responses to environmental stressors" @default.
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