Matches in SemOpenAlex for { <https://semopenalex.org/work/W1695688410> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1695688410 endingPage "379" @default.
- W1695688410 startingPage "374" @default.
- W1695688410 abstract "Once-daily extended-release tacrolimus (Tac-OD) has been introduced as a useful therapeutic option to increase patient adherence to immunosuppressive therapy. This study aimed to evaluate the safety, efficacy and immunosuppressant adherence of conversion from twice-daily tacrolimus (Tac-BID) to Tac-OD in stable adult living donor liver transplant (LDLT) recipients in a single institution.Between February and May 2013, Tac-BID was converted to Tac-OD in recipients followed up for at least 12 months after transplantation and without previous rejection episodes. The switching policy was based on a dose ratio of 1:1 with dose adjustment target trough levels at 3-5 ng/mL. Tacrolimus trough levels, laboratory parameters, metabolic disorders, and adverse events were assessed.A total of 229 patients were enrolled in the study. The median age at conversion was 53 years (range 31-73). The median transplant duration was 35.3 months (range 12.0-95.4). During a median follow-up of 13.5 months after conversion, 9 patients returned to Tac-BID because of adverse events. No acute rejection episodes were observed. Of 214 patients still on Tac-OD at 12 months, 12 (5.6%) received a reduced dose and 95 (44.4%) required an increased dose over baseline. Overall adherence was 82.2% at the end of follow-up.The conversion from Tac-BID to Tac-OD with similar target trough levels after conversion is safe and effective for long-term stable LDLT patients." @default.
- W1695688410 created "2016-06-24" @default.
- W1695688410 creator A5002240113 @default.
- W1695688410 creator A5046402490 @default.
- W1695688410 creator A5082748817 @default.
- W1695688410 creator A5083387138 @default.
- W1695688410 date "2015-08-01" @default.
- W1695688410 modified "2023-09-28" @default.
- W1695688410 title "Conversion of twice-daily to once-daily tacrolimus is safe in stable adult living donor liver transplant recipients" @default.
- W1695688410 cites W1557067957 @default.
- W1695688410 cites W1588296982 @default.
- W1695688410 cites W1592892624 @default.
- W1695688410 cites W1963887931 @default.
- W1695688410 cites W1968506717 @default.
- W1695688410 cites W1972646665 @default.
- W1695688410 cites W2003294033 @default.
- W1695688410 cites W2010500975 @default.
- W1695688410 cites W2016435159 @default.
- W1695688410 cites W2057587361 @default.
- W1695688410 cites W2068650301 @default.
- W1695688410 cites W2069947800 @default.
- W1695688410 cites W2100936524 @default.
- W1695688410 cites W2116897123 @default.
- W1695688410 cites W2143954917 @default.
- W1695688410 cites W2144956356 @default.
- W1695688410 cites W2145186154 @default.
- W1695688410 cites W2146105386 @default.
- W1695688410 doi "https://doi.org/10.1016/s1499-3872(15)60378-2" @default.
- W1695688410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26256081" @default.
- W1695688410 hasPublicationYear "2015" @default.
- W1695688410 type Work @default.
- W1695688410 sameAs 1695688410 @default.
- W1695688410 citedByCount "15" @default.
- W1695688410 countsByYear W16956884102016 @default.
- W1695688410 countsByYear W16956884102017 @default.
- W1695688410 countsByYear W16956884102018 @default.
- W1695688410 countsByYear W16956884102019 @default.
- W1695688410 countsByYear W16956884102020 @default.
- W1695688410 countsByYear W16956884102021 @default.
- W1695688410 crossrefType "journal-article" @default.
- W1695688410 hasAuthorship W1695688410A5002240113 @default.
- W1695688410 hasAuthorship W1695688410A5046402490 @default.
- W1695688410 hasAuthorship W1695688410A5082748817 @default.
- W1695688410 hasAuthorship W1695688410A5083387138 @default.
- W1695688410 hasConcept C126322002 @default.
- W1695688410 hasConcept C126894567 @default.
- W1695688410 hasConcept C141071460 @default.
- W1695688410 hasConcept C197934379 @default.
- W1695688410 hasConcept C2779609443 @default.
- W1695688410 hasConcept C2909675724 @default.
- W1695688410 hasConcept C2911091166 @default.
- W1695688410 hasConcept C31785415 @default.
- W1695688410 hasConcept C71924100 @default.
- W1695688410 hasConcept C90924648 @default.
- W1695688410 hasConceptScore W1695688410C126322002 @default.
- W1695688410 hasConceptScore W1695688410C126894567 @default.
- W1695688410 hasConceptScore W1695688410C141071460 @default.
- W1695688410 hasConceptScore W1695688410C197934379 @default.
- W1695688410 hasConceptScore W1695688410C2779609443 @default.
- W1695688410 hasConceptScore W1695688410C2909675724 @default.
- W1695688410 hasConceptScore W1695688410C2911091166 @default.
- W1695688410 hasConceptScore W1695688410C31785415 @default.
- W1695688410 hasConceptScore W1695688410C71924100 @default.
- W1695688410 hasConceptScore W1695688410C90924648 @default.
- W1695688410 hasIssue "4" @default.
- W1695688410 hasLocation W16956884101 @default.
- W1695688410 hasLocation W16956884102 @default.
- W1695688410 hasOpenAccess W1695688410 @default.
- W1695688410 hasPrimaryLocation W16956884101 @default.
- W1695688410 hasRelatedWork W1695688410 @default.
- W1695688410 hasRelatedWork W1983369934 @default.
- W1695688410 hasRelatedWork W2000836995 @default.
- W1695688410 hasRelatedWork W2011948815 @default.
- W1695688410 hasRelatedWork W2071667523 @default.
- W1695688410 hasRelatedWork W2335359887 @default.
- W1695688410 hasRelatedWork W2476769496 @default.
- W1695688410 hasRelatedWork W2512700381 @default.
- W1695688410 hasRelatedWork W2943169048 @default.
- W1695688410 hasRelatedWork W2997636930 @default.
- W1695688410 hasVolume "14" @default.
- W1695688410 isParatext "false" @default.
- W1695688410 isRetracted "false" @default.
- W1695688410 magId "1695688410" @default.
- W1695688410 workType "article" @default.