Matches in SemOpenAlex for { <https://semopenalex.org/work/W1696142709> ?p ?o ?g. }
- W1696142709 endingPage "235" @default.
- W1696142709 startingPage "187" @default.
- W1696142709 abstract "The Slit family of secreted proteins and their transmembrane receptor, Robo, were originally identified in the nervous system where they function as axon guidance cues and branching factors during development. Since their discovery, a great number of additional roles have been attributed to Slit/Robo signaling, including regulating the critical processes of cell proliferation and cell motility in a variety of cell and tissue types. These processes are often deregulated during cancer progression, allowing tumor cells to bypass safeguarding mechanisms in the cell and the environment in order to grow and escape to new tissues. In the past decade, it has been shown that the expression of Slit and Robo is altered in a wide variety of cancer types, identifying them as potential therapeutic targets. Further, studies have demonstrated dual roles for Slits and Robos in cancer, acting as both oncogenes and tumor suppressors. This bifunctionality is also observed in their roles as axon guidance cues in the developing nervous system, where they both attract and repel neuronal migration. The fact that this signaling axis can have opposite functions depending on the cellular circumstance make its actions challenging to define. Here, we summarize our current understanding of the dual roles that Slit/Robo signaling play in development, epithelial tumor progression, and tumor angiogenesis." @default.
- W1696142709 created "2016-06-24" @default.
- W1696142709 creator A5012827181 @default.
- W1696142709 creator A5089469654 @default.
- W1696142709 date "2012-01-01" @default.
- W1696142709 modified "2023-09-23" @default.
- W1696142709 title "A Roundabout Way to Cancer" @default.
- W1696142709 cites W1535159641 @default.
- W1696142709 cites W1547580946 @default.
- W1696142709 cites W1576609386 @default.
- W1696142709 cites W1619255491 @default.
- W1696142709 cites W1761646048 @default.
- W1696142709 cites W1808377881 @default.
- W1696142709 cites W1911726069 @default.
- W1696142709 cites W1917919273 @default.
- W1696142709 cites W1955158742 @default.
- W1696142709 cites W1964359283 @default.
- W1696142709 cites W1964817578 @default.
- W1696142709 cites W1965232435 @default.
- W1696142709 cites W1965263399 @default.
- W1696142709 cites W1966385034 @default.
- W1696142709 cites W1967450020 @default.
- W1696142709 cites W1968134235 @default.
- W1696142709 cites W1969875830 @default.
- W1696142709 cites W1969884079 @default.
- W1696142709 cites W1972116215 @default.
- W1696142709 cites W1972817334 @default.
- W1696142709 cites W1974300394 @default.
- W1696142709 cites W1975601614 @default.
- W1696142709 cites W1977937744 @default.
- W1696142709 cites W1980050427 @default.
- W1696142709 cites W1980116118 @default.
- W1696142709 cites W1980136245 @default.
- W1696142709 cites W1980379135 @default.
- W1696142709 cites W1983374291 @default.
- W1696142709 cites W1985288684 @default.
- W1696142709 cites W1986036415 @default.
- W1696142709 cites W1986720812 @default.
- W1696142709 cites W1988238602 @default.
- W1696142709 cites W1989168454 @default.
- W1696142709 cites W1989219638 @default.
- W1696142709 cites W1990830502 @default.
- W1696142709 cites W1991944021 @default.
- W1696142709 cites W1992993638 @default.
- W1696142709 cites W1993608710 @default.
- W1696142709 cites W1994044440 @default.
- W1696142709 cites W1994162941 @default.
- W1696142709 cites W1995199211 @default.
- W1696142709 cites W1996698511 @default.
- W1696142709 cites W1996834122 @default.
- W1696142709 cites W1998142094 @default.
- W1696142709 cites W1998182442 @default.
- W1696142709 cites W1998282976 @default.
- W1696142709 cites W2002457930 @default.
- W1696142709 cites W2008790756 @default.
- W1696142709 cites W2009183786 @default.
- W1696142709 cites W2009743745 @default.
- W1696142709 cites W2010084732 @default.
- W1696142709 cites W2010486643 @default.
- W1696142709 cites W2010513401 @default.
- W1696142709 cites W2019129382 @default.
- W1696142709 cites W2019267973 @default.
- W1696142709 cites W2021622839 @default.
- W1696142709 cites W2022435799 @default.
- W1696142709 cites W2024906055 @default.
- W1696142709 cites W2025065524 @default.
- W1696142709 cites W2026308186 @default.
- W1696142709 cites W2026965831 @default.
- W1696142709 cites W2028773225 @default.
- W1696142709 cites W2035467136 @default.
- W1696142709 cites W2036734716 @default.
- W1696142709 cites W2039331712 @default.
- W1696142709 cites W2040827479 @default.
- W1696142709 cites W2041890434 @default.
- W1696142709 cites W2043159830 @default.
- W1696142709 cites W2043665003 @default.
- W1696142709 cites W2043955977 @default.
- W1696142709 cites W2045000982 @default.
- W1696142709 cites W2047112279 @default.
- W1696142709 cites W2047370624 @default.
- W1696142709 cites W2047757962 @default.
- W1696142709 cites W2047806688 @default.
- W1696142709 cites W2050279712 @default.
- W1696142709 cites W2054445281 @default.
- W1696142709 cites W2056220715 @default.
- W1696142709 cites W2056829254 @default.
- W1696142709 cites W2056862346 @default.
- W1696142709 cites W2059830892 @default.
- W1696142709 cites W2065826412 @default.
- W1696142709 cites W2068555773 @default.
- W1696142709 cites W2069262666 @default.
- W1696142709 cites W2069670595 @default.
- W1696142709 cites W2069958696 @default.
- W1696142709 cites W2072842973 @default.
- W1696142709 cites W2073973669 @default.
- W1696142709 cites W2074196937 @default.
- W1696142709 cites W2075998623 @default.
- W1696142709 cites W2077416639 @default.