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• W1696340081 abstract "To describe the natural history and progression of visual loss in eyes with untreated neovascular age-related macular degeneration (AMD).Systematic review and meta-analysis.Four thousand three hundred sixty-two untreated neovascular AMD patients from published interventional studies.A systematic review of the literature from 1980 to August 2005 was performed. Studies reporting disease progression outcomes for untreated patients with neovascular AMD were included. Outcome measures were summarized using simple counts and means. Random effects meta-analyses were conducted and tests of heterogeneity were performed where appropriate.Changes in visual acuity (VA) loss, development of comorbidities, and fellow eye involvement.Fifty-three primary studies were included. Nearly half of the studies (28) were randomized clinical trials. The quality of the studies was high, with over 80% providing level I or II evidence. Mean baseline VA among study patients was 0.64 logarithm of the minimum angle of resolution (logMAR) (approximately 20/87 Snellen). The mean VA change in logMAR progressed from 0.1 (1 line lost) at 3 months to 0.3 (2.7 lines lost) after 12 months and 0.4 (4 lines lost) after 24 months. The proportion of patients who developed severe vision loss (>6 lines) from baseline increased from 21.3% at 6 months to 41.9% by 3 years. The proportion of patients with VA worse than logMAR 1.0 (20/200 Snellen) increased from 19.7% at baseline to 75.7% by 3 years. Neovascular AMD developed in the fellow eye in 12.2% of patients by 12 months and in 26.8% by 4 years. Meta-analyses of vision outcome by subtype of neovascular AMD were not possible.A doubling of the visual angle of presenting VA may be expected to occur in the year after initial presentation in eyes with untreated neovascular AMD. No conclusions can be drawn as to the differences in rates of disease progression by neovascular AMD subtype. The diversity of reporting formats, paucity of long-term natural history data, and heterogeneity among the reported clinical studies impose limits to the clear understanding of long-term prognosis for visual function in neovascular AMD." @default.
• W1696340081 created "2016-06-24" @default.
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• W1696340081 date "2008-01-01" @default.
• W1696340081 modified "2023-10-10" @default.
• W1696340081 title "The Natural History and Prognosis of Neovascular Age-Related Macular Degeneration" @default.
• W1696340081 cites W1487528435 @default.
• W1696340081 cites W150210721 @default.
• W1696340081 cites W1519438798 @default.
• W1696340081 cites W1521704129 @default.
• W1696340081 cites W1543801259 @default.
• W1696340081 cites W1591408774 @default.
• W1696340081 cites W1601975653 @default.
• W1696340081 cites W1802218256 @default.
• W1696340081 cites W1882214116 @default.
• W1696340081 cites W1910188440 @default.
• W1696340081 cites W1967652163 @default.
• W1696340081 cites W1969925859 @default.
• W1696340081 cites W1972406655 @default.
• W1696340081 cites W1974962502 @default.
• W1696340081 cites W1980198157 @default.
• W1696340081 cites W1980863001 @default.
• W1696340081 cites W1985890114 @default.
• W1696340081 cites W1986215651 @default.
• W1696340081 cites W1989515430 @default.
• W1696340081 cites W1992640335 @default.
• W1696340081 cites W2001407709 @default.
• W1696340081 cites W2003586642 @default.
• W1696340081 cites W2009706585 @default.
• W1696340081 cites W2013750450 @default.
• W1696340081 cites W2015171165 @default.
• W1696340081 cites W2017033020 @default.
• W1696340081 cites W2019636431 @default.
• W1696340081 cites W2020612979 @default.
• W1696340081 cites W2020959591 @default.
• W1696340081 cites W2024695401 @default.
• W1696340081 cites W2025195371 @default.
• W1696340081 cites W2028465838 @default.
• W1696340081 cites W2028672340 @default.
• W1696340081 cites W2029878969 @default.
• W1696340081 cites W2031734192 @default.
• W1696340081 cites W2032091027 @default.
• W1696340081 cites W2043264815 @default.
• W1696340081 cites W2046378706 @default.
• W1696340081 cites W2046536553 @default.
• W1696340081 cites W2059580767 @default.
• W1696340081 cites W2060651294 @default.
• W1696340081 cites W2060779614 @default.
• W1696340081 cites W2066326071 @default.
• W1696340081 cites W2066923775 @default.
• W1696340081 cites W2067581689 @default.
• W1696340081 cites W2074931725 @default.
• W1696340081 cites W207576288 @default.
• W1696340081 cites W2079606489 @default.
• W1696340081 cites W2082680958 @default.
• W1696340081 cites W2083054800 @default.
• W1696340081 cites W2087481876 @default.
• W1696340081 cites W2087509751 @default.
• W1696340081 cites W2094310573 @default.
• W1696340081 cites W2112675961 @default.
• W1696340081 cites W2118920977 @default.
• W1696340081 cites W2124415048 @default.
• W1696340081 cites W2126318369 @default.
• W1696340081 cites W2143532939 @default.
• W1696340081 cites W2149277339 @default.
• W1696340081 cites W2149579095 @default.
• W1696340081 cites W2153081819 @default.
• W1696340081 cites W2157522896 @default.
• W1696340081 cites W2159723361 @default.
• W1696340081 cites W233579014 @default.
• W1696340081 cites W2593435691 @default.
• W1696340081 cites W2603205043 @default.
• W1696340081 cites W2606370018 @default.
• W1696340081 cites W2609124342 @default.
• W1696340081 cites W2767344291 @default.
• W1696340081 cites W318413158 @default.
• W1696340081 cites W3185739311 @default.
• W1696340081 cites W3202352366 @default.
• W1696340081 cites W4213290870 @default.
• W1696340081 cites W4230209433 @default.
• W1696340081 cites W4240178088 @default.
• W1696340081 cites W4243337108 @default.
• W1696340081 cites W4243472760 @default.
• W1696340081 cites W4246295494 @default.
• W1696340081 cites W4248800133 @default.
• W1696340081 cites W4251720370 @default.
• W1696340081 cites W4253904110 @default.
• W1696340081 cites W4254216027 @default.
• W1696340081 cites W945208301 @default.
• W1696340081 cites W95909858 @default.

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