FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1696348685> ?p ?o ?g. }

• W1696348685 endingPage "466" @default.
• W1696348685 startingPage "458" @default.
• W1696348685 abstract "Summary The tumour necrosis factor (TNF)-α-induced proteins (TNFAIP)9 and TNFAIP3 play an important pathogenic role in murine arthritis. To clarify their pathophysiological roles in patients with rheumatoid arthritis (RA), we examined their expression and localization in peripheral blood mononuclear cells (PBMC). TNFAIP9 and TNFAIP3 mRNA expression was determined in PBMC of RA patients and healthy subjects (control). Flow cytometry was used to analyse the main TNFAIP9- and TNFAIP3-expressing cell populations. TNFAIP9 and TNFAIP3 mRNA expression levels were examined in vitro on CD14+ cells stimulated with TNF-α and lipopolysaccharide (LPS). The expression levels of TNFAIP9 and TNFAIP3 mRNA were also measured before and 12 weeks after treatment with tocilizumab and abatacept. TNFAIP9 expression was significantly higher, while TNFAIP3 expression was lower in PBMC of RA (n = 36) than the control (n = 24) (each P &lt; 0·05). TNFAIP9 was expressed on CD14+ cells, especially in human leucocyte antigen D-related (HLA-DR)+CD14brightCD16−cells, while TNFAIP3 was expressed mainly on CD3+ T cells. TNF-α and LPS induced TNFAIP9 and TNFAIP3 in human CD14+monocytes in vitro. Treatment with tocilizumab (n = 13), but not abatacept (n = 11), significantly reduced TNFAIP9 mRNA expression in PBMC, which was associated with reduction in the number of circulating CD14bright monocytes. The expression of TNFAIP9 in CD14+ cells was specifically elevated in patients with RA, regulated by TNF-α and LPS, and suppressed by tocilizumab, while TNFAIP3 in PBMC showed different localization and induction patterns." @default.
• W1696348685 created "2016-06-24" @default.
• W1696348685 creator A5006917586 @default.
• W1696348685 creator A5037746646 @default.
• W1696348685 creator A5042533774 @default.
• W1696348685 creator A5057619326 @default.
• W1696348685 creator A5057873917 @default.
• W1696348685 creator A5062464973 @default.
• W1696348685 creator A5075533878 @default.
• W1696348685 creator A5075689087 @default.
• W1696348685 creator A5080797313 @default.
• W1696348685 date "2015-05-15" @default.
• W1696348685 modified "2023-10-09" @default.
• W1696348685 title "Specific overexpression of tumour necrosis factor-α-induced protein (TNFAIP)9 in CD14+CD16− monocytes in patients with rheumatoid arthritis: comparative analysis with TNFAIP3" @default.
• W1696348685 cites W1516406395 @default.
• W1696348685 cites W187351156 @default.
• W1696348685 cites W1963819091 @default.
• W1696348685 cites W1965859404 @default.
• W1696348685 cites W1984378291 @default.
• W1696348685 cites W1993936200 @default.
• W1696348685 cites W1996208529 @default.
• W1696348685 cites W2000905503 @default.
• W1696348685 cites W2013873031 @default.
• W1696348685 cites W2015516540 @default.
• W1696348685 cites W2028483223 @default.
• W1696348685 cites W2037368171 @default.
• W1696348685 cites W2043700785 @default.
• W1696348685 cites W2049147197 @default.
• W1696348685 cites W2051346612 @default.
• W1696348685 cites W2053361385 @default.
• W1696348685 cites W2053889157 @default.
• W1696348685 cites W2064656238 @default.
• W1696348685 cites W2072130349 @default.
• W1696348685 cites W2077003381 @default.
• W1696348685 cites W2094304284 @default.
• W1696348685 cites W2126774987 @default.
• W1696348685 cites W2135403800 @default.
• W1696348685 cites W2147497518 @default.
• W1696348685 cites W2148430942 @default.
• W1696348685 cites W2148586684 @default.
• W1696348685 cites W2152348310 @default.
• W1696348685 cites W2154757713 @default.
• W1696348685 cites W2155702314 @default.
• W1696348685 cites W2171762374 @default.
• W1696348685 cites W2314281189 @default.
• W1696348685 cites W2324384121 @default.
• W1696348685 cites W2326307508 @default.
• W1696348685 cites W4232264301 @default.
• W1696348685 doi "https://doi.org/10.1111/cei.12606" @default.
• W1696348685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4449774" @default.
• W1696348685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25683200" @default.
• W1696348685 hasPublicationYear "2015" @default.
• W1696348685 type Work @default.
• W1696348685 sameAs 1696348685 @default.
• W1696348685 citedByCount "13" @default.
• W1696348685 countsByYear W16963486852016 @default.
• W1696348685 countsByYear W16963486852017 @default.
• W1696348685 countsByYear W16963486852018 @default.
• W1696348685 countsByYear W16963486852019 @default.
• W1696348685 countsByYear W16963486852022 @default.
• W1696348685 countsByYear W16963486852023 @default.
• W1696348685 crossrefType "journal-article" @default.
• W1696348685 hasAuthorship W1696348685A5006917586 @default.
• W1696348685 hasAuthorship W1696348685A5037746646 @default.
• W1696348685 hasAuthorship W1696348685A5042533774 @default.
• W1696348685 hasAuthorship W1696348685A5057619326 @default.
• W1696348685 hasAuthorship W1696348685A5057873917 @default.
• W1696348685 hasAuthorship W1696348685A5062464973 @default.
• W1696348685 hasAuthorship W1696348685A5075533878 @default.
• W1696348685 hasAuthorship W1696348685A5075689087 @default.
• W1696348685 hasAuthorship W1696348685A5080797313 @default.
• W1696348685 hasBestOaLocation W16963486851 @default.
• W1696348685 hasConcept C114684123 @default.
• W1696348685 hasConcept C137061746 @default.
• W1696348685 hasConcept C159654299 @default.
• W1696348685 hasConcept C167672396 @default.
• W1696348685 hasConcept C17991360 @default.
• W1696348685 hasConcept C202751555 @default.
• W1696348685 hasConcept C203014093 @default.
• W1696348685 hasConcept C2777178219 @default.
• W1696348685 hasConcept C2777575956 @default.
• W1696348685 hasConcept C2778513237 @default.
• W1696348685 hasConcept C2779605438 @default.
• W1696348685 hasConcept C2780653079 @default.
• W1696348685 hasConcept C2781462264 @default.
• W1696348685 hasConcept C553184892 @default.
• W1696348685 hasConcept C55493867 @default.
• W1696348685 hasConcept C71924100 @default.
• W1696348685 hasConcept C86803240 @default.
• W1696348685 hasConcept C8891405 @default.
• W1696348685 hasConceptScore W1696348685C114684123 @default.
• W1696348685 hasConceptScore W1696348685C137061746 @default.
• W1696348685 hasConceptScore W1696348685C159654299 @default.
• W1696348685 hasConceptScore W1696348685C167672396 @default.
• W1696348685 hasConceptScore W1696348685C17991360 @default.
• W1696348685 hasConceptScore W1696348685C202751555 @default.
• W1696348685 hasConceptScore W1696348685C203014093 @default.
• W1696348685 hasConceptScore W1696348685C2777178219 @default.

• next