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- W169638997 abstract "Radioimmunotherapy (RIT) by direct administration of radiolabelled MAbs was applied in 43 patients with malignant glioma (42 brain and 1 spinal cord). In 31 tumour has recurred following failure of previous surgery, radiotherapy and chemotherapy. 26 of these underwent further operation obtaining radical resection In 9 and partial removal of tumour in 17. Conversely 12 cases received RIT after surgery and radiotherapy of primary tumour. The radiopharmaceutical was directly injected in the tumour (14 pat.) or in the cavity left by surgery (29 pat.) by means of a removable (18 cases) or indwelling (25) catheter. Two murine MAbs BC-2 and BC-4 were employed singly or as a cocktail. Their target is tenascin which is abundantly expressed in tumour stroma but completely absent in healthy cerebral tissue. MAbs were labelled with I-131 which was administered at escalating doses from 185 MBq as far as 2035 MBq. RIT cycles were monthly repeated up to 5 to maximize cumulative radiation dose. No systemic nor cerebral adverse effect occurred. HAMA production was recorded in 35% of cases, at quite low titer, but did not affect MAbs distribution during subsequent cycles. The direct MAbs injection led to their high concentration in the tumour for amore » long time (mean effective T/2 62 hours). The radiation dose to neoplastic tissue resulted, on average, more than 250 Gy per cycle. The cumulative dose exceeded, in some cases, 1000 Gy. The homogeneous distribution of MAbs through whole tumour mass was scintigraphically and autoradiographically demonstrated. 34 out 43 patient are so far evaluable. Their median survival was 18 months (versus 12 months achievable by traditional treatments). In 9 pat. the disease was stabilized (median length 12 months), in 7 a Partial remission was obtained (9 months) and in 6 a complete remission of neoplastic mass (median duration 22 months, range 11-39) was achieved (response rate 38, 2%).« less" @default.
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- W169638997 date "1994-05-01" @default.
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- W169638997 title "Possibility of control of malignant gliomas by direct intratumour or intralesional radioimmunotherapy" @default.
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