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• W169643058 endingPage "1793" @default.
• W169643058 startingPage "1763" @default.
• W169643058 abstract "This chapter focuses on immunoglobulins and immunocytes in milk. The chapter outlines the mammary gland anatomy and milk biochemistry. Under the influence of the hormones of pregnancy and lactation such as prolactin, progesterone, and local growth factors—the narrow ducts bud alveoli and parenchymal tissue progressively replaces the fat pads of the undeveloped mammary gland (MG). During lactation, leukocytes are confined to clusters between distended alveoli. Many milk cells are associated with immunoglobulins, including T cells. Much of the surface immunoglobulin expression on milk cells reflect immunoglobulins bound to Fc receptors, which decorate neutrophils and monocytes in all species. Cells from blood enter the MG, transit the alveolar epithelium, and enter the milk. The higher expression of CD45RO on both milk CD4 and CD8 cells also resembles that of T cells in the gut and buccal mucosa. Some differences between blood and milk lymphocytes could be microenvironmental. Experimental studies suggest that milk lymphocytes are less responsive to mitogens and that colostrum can inhibit the mitogenic response of peripheral blood lymphocytes." @default.
• W169643058 created "2016-06-24" @default.
• W169643058 creator A5053576640 @default.
• W169643058 creator A5069985236 @default.
• W169643058 date "2005-01-01" @default.
• W169643058 modified "2023-09-27" @default.
• W169643058 title "Immunoglobulins and Immunocytes in the Mammary Gland and Its Secretions" @default.
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