FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1696581921> ?p ?o ?g. }

• W1696581921 endingPage "6256" @default.
• W1696581921 startingPage "6250" @default.
• W1696581921 abstract "Abstract Transplantation of an excessive number of islets of Langerhans (two to four pancreata per recipient) into patients with type I diabetes is required to restore euglycemia. Hypoxia, nutrient deprivation, local inflammation, and the β cell inflammatory response (up-regulation of NF-κB-dependent genes such as inos) result in β cell destruction in the early post-transplantation period. Genetic engineering of islets with anti-inflammatory and antiapoptotic genes may prevent β cell loss and primary nonfunction. We have shown in vitro that A20 inhibits NF-κB activation in islets and protects from cytokine- and death receptor-mediated apoptosis. In vivo, protection of newly transplanted islets would reduce the number of islets required for successful transplantation. Transplantation of 500 B6/AF1 mouse islets into syngeneic, diabetic recipients resulted in a cure rate of 100% within 5 days. Transplantation of 250 islets resulted in a cure rate of only 20%. Transplantation of 250 islets overexpressing A20 resulted in a cure rate of 75% with a mean time to cure of 5.2 days, comparable to that achieved with 500 islets. A20-expressing islets preserve functional β cell mass and are protected from cell death. These data demonstrate that A20 is an ideal cytoprotective gene therapy candidate for islet transplantation." @default.
• W1696581921 created "2016-06-24" @default.
• W1696581921 creator A5015016192 @default.
• W1696581921 creator A5048165415 @default.
• W1696581921 creator A5049412306 @default.
• W1696581921 creator A5049420931 @default.
• W1696581921 creator A5056907292 @default.
• W1696581921 creator A5067720195 @default.
• W1696581921 creator A5085873910 @default.
• W1696581921 creator A5086204848 @default.
• W1696581921 creator A5086648114 @default.
• W1696581921 date "2003-06-15" @default.
• W1696581921 modified "2023-09-30" @default.
• W1696581921 title "Genetic Engineering of a Suboptimal Islet Graft with A20 Preserves β Cell Mass and Function" @default.
• W1696581921 cites W1507472194 @default.
• W1696581921 cites W1521689717 @default.
• W1696581921 cites W1569068313 @default.
• W1696581921 cites W1599588446 @default.
• W1696581921 cites W1662237934 @default.
• W1696581921 cites W1967766455 @default.
• W1696581921 cites W1972272933 @default.
• W1696581921 cites W1976874472 @default.
• W1696581921 cites W1976913110 @default.
• W1696581921 cites W1984061256 @default.
• W1696581921 cites W1986265010 @default.
• W1696581921 cites W1993936200 @default.
• W1696581921 cites W2018622236 @default.
• W1696581921 cites W2031585752 @default.
• W1696581921 cites W2035055926 @default.
• W1696581921 cites W2054133911 @default.
• W1696581921 cites W2060275191 @default.
• W1696581921 cites W2061497413 @default.
• W1696581921 cites W2069292681 @default.
• W1696581921 cites W2097877954 @default.
• W1696581921 cites W2105668301 @default.
• W1696581921 cites W2114445152 @default.
• W1696581921 cites W2116345973 @default.
• W1696581921 cites W2121241877 @default.
• W1696581921 cites W2126295203 @default.
• W1696581921 cites W2127857033 @default.
• W1696581921 cites W2130888215 @default.
• W1696581921 cites W2131095976 @default.
• W1696581921 cites W2136127635 @default.
• W1696581921 cites W2139132468 @default.
• W1696581921 cites W2140318963 @default.
• W1696581921 cites W2143642767 @default.
• W1696581921 cites W2154344345 @default.
• W1696581921 cites W2160289551 @default.
• W1696581921 cites W2167514893 @default.
• W1696581921 cites W2169286453 @default.
• W1696581921 cites W2177829601 @default.
• W1696581921 cites W2328786770 @default.
• W1696581921 cites W2432327939 @default.
• W1696581921 cites W4232184056 @default.
• W1696581921 cites W7834821 @default.
• W1696581921 doi "https://doi.org/10.4049/jimmunol.170.12.6250" @default.
• W1696581921 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12794157" @default.
• W1696581921 hasPublicationYear "2003" @default.
• W1696581921 type Work @default.
• W1696581921 sameAs 1696581921 @default.
• W1696581921 citedByCount "103" @default.
• W1696581921 countsByYear W16965819212012 @default.
• W1696581921 countsByYear W16965819212013 @default.
• W1696581921 countsByYear W16965819212014 @default.
• W1696581921 countsByYear W16965819212015 @default.
• W1696581921 countsByYear W16965819212016 @default.
• W1696581921 countsByYear W16965819212017 @default.
• W1696581921 countsByYear W16965819212018 @default.
• W1696581921 countsByYear W16965819212019 @default.
• W1696581921 countsByYear W16965819212020 @default.
• W1696581921 countsByYear W16965819212021 @default.
• W1696581921 countsByYear W16965819212022 @default.
• W1696581921 countsByYear W16965819212023 @default.
• W1696581921 crossrefType "journal-article" @default.
• W1696581921 hasAuthorship W1696581921A5015016192 @default.
• W1696581921 hasAuthorship W1696581921A5048165415 @default.
• W1696581921 hasAuthorship W1696581921A5049412306 @default.
• W1696581921 hasAuthorship W1696581921A5049420931 @default.
• W1696581921 hasAuthorship W1696581921A5056907292 @default.
• W1696581921 hasAuthorship W1696581921A5067720195 @default.
• W1696581921 hasAuthorship W1696581921A5085873910 @default.
• W1696581921 hasAuthorship W1696581921A5086204848 @default.
• W1696581921 hasAuthorship W1696581921A5086648114 @default.
• W1696581921 hasBestOaLocation W16965819211 @default.
• W1696581921 hasConcept C126322002 @default.
• W1696581921 hasConcept C134018914 @default.
• W1696581921 hasConcept C165220095 @default.
• W1696581921 hasConcept C190283241 @default.
• W1696581921 hasConcept C203014093 @default.
• W1696581921 hasConcept C2776914184 @default.
• W1696581921 hasConcept C2911091166 @default.
• W1696581921 hasConcept C31573885 @default.
• W1696581921 hasConcept C502942594 @default.
• W1696581921 hasConcept C54355233 @default.
• W1696581921 hasConcept C555293320 @default.
• W1696581921 hasConcept C71924100 @default.
• W1696581921 hasConcept C86803240 @default.
• W1696581921 hasConceptScore W1696581921C126322002 @default.

• next