Matches in SemOpenAlex for { <https://semopenalex.org/work/W1696613117> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1696613117 abstract "Since the basic defect in cystic fibrosis (CF) involves a defective cell surface protein controlling chloride channel transport across cell membranes, medications which are developed to enhance the cystic fibrosis transmembrane conductance regulator (CFTR) protein should result in improvement in patients with CF. The presence of over 2000 genetic mutations have made these efforts difficult. However, a classification scheme of these mutations has allowed three basic approaches: to bypass missense mutations by having the cellular translation machinery read through the premature stop codon, to enhance the “gating” function of the CFTR protein on the cell surface, and to correct a defective CFTR protein “trafficking” though the cytoplasm to be inserted properly in the cell membrane. This chapter will review clinical trials using drugs which are designed to enhance CFTR protein activity." @default.
- W1696613117 created "2016-06-24" @default.
- W1696613117 creator A5033287589 @default.
- W1696613117 date "2015-08-24" @default.
- W1696613117 modified "2023-10-16" @default.
- W1696613117 title "Medications to Enhance CFTR Activity" @default.
- W1696613117 cites W1988397255 @default.
- W1696613117 cites W2031633609 @default.
- W1696613117 cites W2035131077 @default.
- W1696613117 cites W2051836609 @default.
- W1696613117 cites W2071407356 @default.
- W1696613117 cites W2082171543 @default.
- W1696613117 cites W2085811948 @default.
- W1696613117 cites W2087220860 @default.
- W1696613117 cites W2095687634 @default.
- W1696613117 cites W2159814661 @default.
- W1696613117 cites W2162070501 @default.
- W1696613117 cites W2320285826 @default.
- W1696613117 cites W766415713 @default.
- W1696613117 doi "https://doi.org/10.5772/60768" @default.
- W1696613117 hasPublicationYear "2015" @default.
- W1696613117 type Work @default.
- W1696613117 sameAs 1696613117 @default.
- W1696613117 citedByCount "0" @default.
- W1696613117 crossrefType "book-chapter" @default.
- W1696613117 hasAuthorship W1696613117A5033287589 @default.
- W1696613117 hasBestOaLocation W16966131171 @default.
- W1696613117 hasConcept C104317684 @default.
- W1696613117 hasConcept C105580179 @default.
- W1696613117 hasConcept C144647389 @default.
- W1696613117 hasConcept C145822097 @default.
- W1696613117 hasConcept C1491633281 @default.
- W1696613117 hasConcept C149364088 @default.
- W1696613117 hasConcept C170493617 @default.
- W1696613117 hasConcept C185592680 @default.
- W1696613117 hasConcept C190062978 @default.
- W1696613117 hasConcept C24530287 @default.
- W1696613117 hasConcept C2776938444 @default.
- W1696613117 hasConcept C2778428886 @default.
- W1696613117 hasConcept C41625074 @default.
- W1696613117 hasConcept C501734568 @default.
- W1696613117 hasConcept C54355233 @default.
- W1696613117 hasConcept C55493867 @default.
- W1696613117 hasConcept C60644358 @default.
- W1696613117 hasConcept C6929976 @default.
- W1696613117 hasConcept C71924100 @default.
- W1696613117 hasConcept C75563809 @default.
- W1696613117 hasConcept C86803240 @default.
- W1696613117 hasConcept C95444343 @default.
- W1696613117 hasConceptScore W1696613117C104317684 @default.
- W1696613117 hasConceptScore W1696613117C105580179 @default.
- W1696613117 hasConceptScore W1696613117C144647389 @default.
- W1696613117 hasConceptScore W1696613117C145822097 @default.
- W1696613117 hasConceptScore W1696613117C1491633281 @default.
- W1696613117 hasConceptScore W1696613117C149364088 @default.
- W1696613117 hasConceptScore W1696613117C170493617 @default.
- W1696613117 hasConceptScore W1696613117C185592680 @default.
- W1696613117 hasConceptScore W1696613117C190062978 @default.
- W1696613117 hasConceptScore W1696613117C24530287 @default.
- W1696613117 hasConceptScore W1696613117C2776938444 @default.
- W1696613117 hasConceptScore W1696613117C2778428886 @default.
- W1696613117 hasConceptScore W1696613117C41625074 @default.
- W1696613117 hasConceptScore W1696613117C501734568 @default.
- W1696613117 hasConceptScore W1696613117C54355233 @default.
- W1696613117 hasConceptScore W1696613117C55493867 @default.
- W1696613117 hasConceptScore W1696613117C60644358 @default.
- W1696613117 hasConceptScore W1696613117C6929976 @default.
- W1696613117 hasConceptScore W1696613117C71924100 @default.
- W1696613117 hasConceptScore W1696613117C75563809 @default.
- W1696613117 hasConceptScore W1696613117C86803240 @default.
- W1696613117 hasConceptScore W1696613117C95444343 @default.
- W1696613117 hasLocation W16966131171 @default.
- W1696613117 hasLocation W16966131172 @default.
- W1696613117 hasOpenAccess W1696613117 @default.
- W1696613117 hasPrimaryLocation W16966131171 @default.
- W1696613117 hasRelatedWork W1546976336 @default.
- W1696613117 hasRelatedWork W2053621717 @default.
- W1696613117 hasRelatedWork W2080925409 @default.
- W1696613117 hasRelatedWork W2088414254 @default.
- W1696613117 hasRelatedWork W2113074631 @default.
- W1696613117 hasRelatedWork W2135063244 @default.
- W1696613117 hasRelatedWork W2411081049 @default.
- W1696613117 hasRelatedWork W2531669199 @default.
- W1696613117 hasRelatedWork W4244049418 @default.
- W1696613117 hasRelatedWork W2041984778 @default.
- W1696613117 isParatext "false" @default.
- W1696613117 isRetracted "false" @default.
- W1696613117 magId "1696613117" @default.
- W1696613117 workType "book-chapter" @default.