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• W1697392511 abstract "Cutaneous melanoma is a malignant tumour that arises from pigmented skin cells – melanocytes, represents the most rapidly increasing cancer worldwide which is causing significant public health problem. During the past decade a significant progress has been made in the understanding of genesis and progression of melanocytic lesions. However treatment of malignant melanomas is in a majority of cases limited to surgical excision of the primary tumours or metastases. In advanced metastatic disease there are few treatment options. The present thesis reviews current knowledge on epidemiology, ethiology, pathology and treatment options of the benign and malignant melanocytic tumours and concentrates on the analysis of several molecules that are thought to play a role in the processes of cell growth, apoptosis, division, motility and adhesion as well as regulation of cytoskeletal components, protein phosphorylation, cell-cycle and cell survival. Archival material from fine needle aspirates as well as formalin-fixed tumour tissue was used in the study. Primary benign and malignant melanocytic tumours as well as metastatic melanomas were included in the study. The expression of the following proteins in malignant and benign melanocytic tumours was analyzed: S100, CD40, CD44, Bcl-2, Ki-67, COX-2 and HSP90. The expression patterns of the proteins were correlated to pathomorphological properties of the tumours as well as clinical parameters. Moreover, a presence of the BRAF gene mutation V600 has been analyzed in metastases from malignant melanomas. We found that melanocytic tumours are heterogeneous in respect to expression of the analyzed proteins as well as mutational status. Analysis of biomarkers and genetic aberrations might therefore be of importance for predicting the biological behaviour of the tumours. The results of the study are discussed in the light of eventual prognostic, diagnostic and therapeutic application of the analyzed proteins and mutational status." @default.
• W1697392511 created "2016-06-24" @default.
• W1697392511 creator A5009623823 @default.
• W1697392511 date "2011-11-11" @default.
• W1697392511 modified "2023-09-27" @default.
• W1697392511 title "Assessment of prognostic markers in benign and malignant melanocytic tumours" @default.
• W1697392511 cites W109683301 @default.
• W1697392511 cites W142472088 @default.
• W1697392511 cites W14710632 @default.
• W1697392511 cites W1484388505 @default.
• W1697392511 cites W1487350429 @default.
• W1697392511 cites W1490721606 @default.
• W1697392511 cites W1521734228 @default.
• W1697392511 cites W1524477650 @default.
• W1697392511 cites W1533045633 @default.
• W1697392511 cites W1545177819 @default.
• W1697392511 cites W1545715882 @default.
• W1697392511 cites W1560370693 @default.
• W1697392511 cites W1577146075 @default.
• W1697392511 cites W1593640213 @default.
• W1697392511 cites W1595730887 @default.
• W1697392511 cites W1600775215 @default.
• W1697392511 cites W1603789301 @default.
• W1697392511 cites W1651215666 @default.
• W1697392511 cites W165248342 @default.
• W1697392511 cites W1654343738 @default.
• W1697392511 cites W1718855460 @default.
• W1697392511 cites W1745158913 @default.
• W1697392511 cites W1821265034 @default.
• W1697392511 cites W1848138727 @default.
• W1697392511 cites W1861806380 @default.
• W1697392511 cites W1917619044 @default.
• W1697392511 cites W1940054769 @default.
• W1697392511 cites W1963695279 @default.
• W1697392511 cites W1963776674 @default.
• W1697392511 cites W1965037168 @default.
• W1697392511 cites W1965947177 @default.
• W1697392511 cites W1967354499 @default.
• W1697392511 cites W1967640773 @default.
• W1697392511 cites W1969465093 @default.
• W1697392511 cites W1970195561 @default.
• W1697392511 cites W1970700441 @default.
• W1697392511 cites W1971435587 @default.
• W1697392511 cites W1971512270 @default.
• W1697392511 cites W1974208182 @default.
• W1697392511 cites W1974919389 @default.
• W1697392511 cites W1975011074 @default.
• W1697392511 cites W1978113416 @default.
• W1697392511 cites W1979043172 @default.
• W1697392511 cites W1980078856 @default.
• W1697392511 cites W1981451309 @default.
• W1697392511 cites W1982150427 @default.
• W1697392511 cites W1982635732 @default.
• W1697392511 cites W1983412131 @default.
• W1697392511 cites W1984443759 @default.
• W1697392511 cites W1987372760 @default.
• W1697392511 cites W1987691375 @default.
• W1697392511 cites W1988692190 @default.
• W1697392511 cites W1990802782 @default.
• W1697392511 cites W1991175004 @default.
• W1697392511 cites W1992108489 @default.
• W1697392511 cites W1992142919 @default.
• W1697392511 cites W1992216855 @default.
• W1697392511 cites W1993592556 @default.
• W1697392511 cites W1994089726 @default.
• W1697392511 cites W1994108115 @default.
• W1697392511 cites W1995692965 @default.
• W1697392511 cites W1998826717 @default.
• W1697392511 cites W2001099078 @default.
• W1697392511 cites W2002288639 @default.
• W1697392511 cites W2003403912 @default.
• W1697392511 cites W2004519256 @default.
• W1697392511 cites W2005310013 @default.
• W1697392511 cites W2007147082 @default.
• W1697392511 cites W2007180952 @default.
• W1697392511 cites W2007340510 @default.
• W1697392511 cites W2007526923 @default.
• W1697392511 cites W2008144998 @default.
• W1697392511 cites W2008694460 @default.
• W1697392511 cites W2008997314 @default.
• W1697392511 cites W2009076132 @default.
• W1697392511 cites W2009183764 @default.
• W1697392511 cites W2009951463 @default.
• W1697392511 cites W2010080964 @default.
• W1697392511 cites W2010990467 @default.
• W1697392511 cites W2013595378 @default.
• W1697392511 cites W2013628667 @default.
• W1697392511 cites W2013689372 @default.
• W1697392511 cites W2014514145 @default.
• W1697392511 cites W2015015957 @default.
• W1697392511 cites W2016872958 @default.
• W1697392511 cites W2017484796 @default.
• W1697392511 cites W2017771253 @default.
• W1697392511 cites W2018155127 @default.
• W1697392511 cites W2018626410 @default.
• W1697392511 cites W2019496774 @default.
• W1697392511 cites W2021777937 @default.
• W1697392511 cites W2022261774 @default.
• W1697392511 cites W2022481874 @default.
• W1697392511 cites W2023065528 @default.

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