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- W16984911 abstract "Objective To investigate the effects of anthocyanin from blueberry on learning and memory in aged mice. Method Twenty-four Kunming mice aged 15-mo were randomly divided into control group (Cont), blueberry extracts group (BBE) and blueberry monomer group (BBM). The mice in the Cont, BBE and BBM groups received intragastric administration of distilled water, blueberry extracts (200 mg/ kg bw · d) and monomer (50 mg/ kg bw · d) respectively for 6 w.The learning and memory function was evaluated by Morris water maze and passive avoidance test. The contents of lipofuscin in brain tissues, the contents of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in plasma and brain tissue were detected separately. Results Compared with control group , the retention latency in passive avoidance test in BBE and BBM group was significantly increased (P0.05). The escape latency in Morris water maze in BBE and BBM group was significantly shorter (P0.05) than those in Cont group. The time in the quadrant was longer and the number of crossing platform was significantly increased (P0.05). The levels of lipofuscin in brain tissue and MDA in plasma and brain tissue were significantly decreased (P0.05 or P0.01), while the activity of SOD in plasma and brain tissue was significantly increased (P0.01). The differences in cognitive performance between BBE and BBM group were not significant (P0.05). Conclusion Cyanidin-3-O-galactoside from blueberry could improve learning and memory in aged mice significantly. The mechanism of its effects might be related to reducing the levels of lipofuscin in brain and enhancing the function of antioxidant defence system." @default.
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- W16984911 date "2009-01-01" @default.
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- W16984911 title "Study on the effect of anthocyanin from blueberry on improving learning and memory in aged mice." @default.
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